Gene: MYH14

79784
DFNA4|DFNA4A|FP17425|MHC16|MYH17|NMHC II-C|NMHC-II-C|PNMHH|myosin
myosin heavy chain 14
protein-coding
19q13.33
Ensembl:ENSG00000105357 MIM:608568 Vega:OTTHUMG00000183034 UniprotKB:Q7Z406
NG_011645.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.402e-1 (AD)  6.114e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11670669chr19:50248541 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIP1R0.821
MVB12B0.792
LLGL10.792
PRKCSH0.786
LSS0.786
ARHGAP230.783
HDAC110.778
FNBP10.775
PACS20.774
HIRIP30.762

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.572
OR4F5-0.538
FER1L6-0.313
ASB9-0.294
GADL1-0.283
SERPINB5-0.282
BMP5-0.282
IL24-0.282
GSDMA-0.279
DSG2-0.278

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01944(S)-blebbistatinSmall Molecule-ExperimentalTarget
DB03126Mant-AdpSmall MoleculeExperimentalTarget
DB04444Tetrafluoroaluminate IonSmall Molecule21340-02-3ExperimentalTarget
DB07468(3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-oneSmall MoleculeExperimentalTarget
DB07469(3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-oneSmall MoleculeExperimentalTarget
DB07470(3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-oneSmall MoleculeExperimentalTarget
DB08276trifluoro-[hydroxy-[hydroxy-[2-(N-methyl-2-nitro-anilino)ethoxy]phosphoryl]oxy-phosphoryl]oxy-beryllium(1-)Small MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of MYH14 mRNA"23829299
D000082AcetaminophenAcetaminophen results in decreased expression of MYH14 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MYH14 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MYH14 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MYH14 mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of MYH14 mRNA21298039
D001151ArsenicArsenic affects the methylation of MYH14 gene25304211
D001151ArsenicArsenic results in decreased expression of MYH14 protein19818359
D004958EstradiolEstradiol results in increased expression of MYH14 mRNA15289156|1948475
C006780bisphenol Abisphenol A results in decreased expression of MYH14 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of MYH14 protein24552547
C006780bisphenol Abisphenol A results in increased methylation of MYH14 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of MYH14 protein28903499
D002104CadmiumCadmium results in increased expression of MYH14 mRNA24376830
C018021cobaltous chloridecobaltous chloride results in decreased expression of MYH14 mRNA24386269
D003300CopperCopper deficiency results in increased expression of MYH14 mRNA26033743
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of MYH14 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of MYH14 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of MYH14 mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MYH14 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of MYH14 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of MYH14 mRNA]20032058
C000944dicrotophosdicrotophos results in increased expression of MYH14 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of MYH14 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MYH14 mRNA15289156
D002117CalcitriolCalcitriol results in increased expression of MYH14 mRNA26485663
C082360fipronilfipronil results in increased expression of MYH14 mRNA23962444
D019833GenisteinESR1 promotes the reaction [Genistein results in increased expression of MYH14 protein]20884965
D019833GenisteinGenistein results in increased expression of MYH14 protein20884965
D019833GenisteinGenistein results in increased expression of MYH14 mRNA15289156
C016517indole-3-carbinolindole-3-carbinol affects the expression of MYH14 mRNA21396975
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MYH14 mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MYH14 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MYH14 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MYH14 mRNA"25620056
C028007nickel monoxidenickel monoxide results in increased expression of MYH14 mRNA19167457
D000073878Palm OilPalm Oil results in increased expression of MYH14 mRNA18042831
C410127PCB 180PCB 180 results in increased expression of MYH14 mRNA23829299
D010656PhenylephrinePhenylephrine results in decreased expression of MYH14 mRNA18158353
C006253pirinixic acidpirinixic acid results in increased expression of MYH14 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in decreased expression of MYH14 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of MYH14 mRNA23018184
D011441PropylthiouracilPropylthiouracil results in decreased expression of MYH14 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of MYH14 mRNA19167446
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MYH14 mRNA21427059
C017947sodium arsenitesodium arsenite affects the methylation of MYH14 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of MYH14 protein28918527
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MYH14 mRNA21641980
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of MYH14 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MYH14 mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MYH14 protein27105554
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MYH14 mRNA21215274
C057693troglitazonetroglitazone results in decreased expression of MYH14 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of MYH14 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MYH14 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of MYH14 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of MYH14 mRNA21427059
C025643vinclozolinvinclozolin affects the expression of MYH14 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of MYH14 mRNA23034163
D015032ZincZinc deficiency results in decreased expression of MYH14 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IEA-  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IEA-  
GO:0016887ATPase activity-IDA24072716  
GO:0030898actin-dependent ATPase activitycontributes_toIDA24072716  
GO:0051015actin filament bindingcontributes_toIDA24072716  
GO ID GO Term Qualifier Evidence PubMed
GO:0003009skeletal muscle contraction-IMP21480433  
GO:0007018microtubule-based movement-IEA-  
GO:0007519skeletal muscle tissue development-IMP21480433  
GO:0007605sensory perception of sound-IMP21480433  
GO:0008360regulation of cell shape-IEA-  
GO:0019228neuronal action potential-IMP21480433  
GO:0031032actomyosin structure organization-IDA24072716  
GO:0070584mitochondrion morphogenesis-IMP21480433  
GO:0071625vocalization behavior-IMP21480433  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016460myosin II complex-IDA24072716  
GO:0042641actomyosin-IDA24072716  
GO:0070062extracellular exosome-HDA19056867  
GO:0097513myosin II filament-IDA24072716  
KEGG ID KEGG Term
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-373755Semaphorin interactionsIEA
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-400685Sema4D in semaphorin signalingIEA
R-HSA-416572Sema4D induced cell migration and growth-cone collapseIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5625740RHO GTPases activate PKNsIEA
R-HSA-5625900RHO GTPases activate CITIEA
R-HSA-5627117RHO GTPases Activate ROCKsIEA
R-HSA-5627123RHO GTPases activate PAKsIEA
R-HSA-5627123RHO GTPases activate PAKsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal