Gene: ST7

7982
ETS7q|FAM4A|FAM4A1|HELG|RAY1|SEN4|TSG7
suppression of tumorigenicity 7
protein-coding
7q31.2
Ensembl:ENSG00000004866 MIM:600833 Vega:OTTHUMG00000023888 UniprotKB:Q9NRC1
NG_047088.1
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.723e-1 (AD)  7.213e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs74335618chr7:117175543 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20707126chr7:116750996ST77.800e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNOT40.857
TRAPPC20.854
TOR1B0.854
PYGO20.853
RERE0.847
BRAP0.845
FBXO420.842
NFYC0.842
MKRN20.839
NUDT90.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.626
OR4F29-0.578
KLRB1-0.338
TFPI2-0.331
KLRF1-0.32
C5orf64-0.314
IL2RB-0.307
CTNNA3-0.303
SH2D1A-0.302
CETP-0.302

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ST7 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ST7 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ST7 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ST7 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of ST7 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ST7 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ST7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ST7 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST7 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST7 mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ST7 mRNA22228805
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of ST7 mRNA17404688
C044887beta-methylcholinebeta-methylcholine affects the expression of ST7 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ST7 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ST7 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ST7 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ST7 mRNA27339419
D019327Copper SulfateCopper Sulfate results in decreased expression of ST7 mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ST7 mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of ST7 mRNA19561079
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ST7 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ST7 mRNA]17942915
D002117CalcitriolCalcitriol results in decreased expression of ST7 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of ST7 mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ST7 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ST7 mRNA23649840
D005047EtoposideST7 protein affects the susceptibility to Etoposide16217747
D018120FinasterideFinasteride results in increased expression of ST7 mRNA24136188
C071834glycidamideglycidamide results in decreased expression of ST7 mRNA17822822
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ST7 mRNA25613284
C008493methylselenic acidmethylselenic acid affects the expression of ST7 mRNA14617803
C008493methylselenic acidmethylselenic acid results in decreased expression of ST7 mRNA18548127
D016685MitomycinST7 protein affects the susceptibility to Mitomycin16217747
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ST7 mRNA25729387
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ST7 mRNA26272509
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of ST7 mRNA17404688
C009277sodium arsenatesodium arsenate results in decreased expression of ST7 mRNA23922661
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of ST7 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of ST7 mRNA21592394
C004648testosterone enanthatetestosterone enanthate affects the expression of ST7 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST7 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ST7 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of ST7 gene26756918
D019772TopotecanST7 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ST7 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ST7 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ST7 gene27618143
C012589trichostatin Atrichostatin A affects the expression of ST7 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of ST7 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ST7 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ST7 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of ST7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ST7 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ST7 mRNA24383497
D014635Valproic AcidValproic Acid results in decreased expression of ST7 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ST7 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal