Gene: ARHGAP28

79822
-
Rho GTPase activating protein 28
protein-coding
18p11.31
Ensembl:ENSG00000088756 MIM:610592 Vega:OTTHUMG00000167698 UniprotKB:Q9P2N2
NC_000018.10
PubMed|SNP Mapped
1   ANCO-SNPs
OD|CD|AD
1   
6.994e-1 (AD)  7.701e-1 (ND)   (Frontal_Cortex)
8.164e-1 (AD)  2.631e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2567261chr18:6868926 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARL150.699
LYST0.698
GULP10.694
CSMD30.693
CHM0.688
KLF80.688
PPP1R12A0.686
EXOC60.683
RASAL20.683
MEF2A0.683

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.428
FXYD4-0.39
LHPP-0.386
PAQR6-0.385
TGFB3-0.374
RBP1-0.373
RHBDL2-0.371
KIF1C-0.366
BCAS1-0.36
CPM-0.355

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ARHGAP28 mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP28 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP28 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP28 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP28 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ARHGAP28 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ARHGAP28 mRNA22100608
D001280AtrazineAtrazine results in increased expression of ARHGAP28 mRNA25929836
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARHGAP28 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ARHGAP28 mRNA20660070
C006780bisphenol Abisphenol A affects the expression of ARHGAP28 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of ARHGAP28 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of ARHGAP28 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ARHGAP28 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ARHGAP28 mRNA17484886
D002737ChloropreneChloroprene results in decreased expression of ARHGAP28 mRNA23125180
C089595cylindrospermopsincylindrospermopsin results in increased expression of ARHGAP28 mRNA24921660
D004041Dietary FatsDietary Fats results in increased expression of ARHGAP28 mRNA25016146
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ARHGAP28 mRNA"27840820
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGAP28 mRNA22079256
C039281furanfuran results in increased expression of ARHGAP28 mRNA27387713
D017313FenretinideFenretinide results in increased expression of ARHGAP28 mRNA28973697
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ARHGAP28 mRNA28001369
D015735MifepristoneMifepristone results in increased expression of ARHGAP28 mRNA17584828
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ARHGAP28 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ARHGAP28 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ARHGAP28 mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ARHGAP28 mRNA26705709
D010634PhenobarbitalPhenobarbital results in increased expression of ARHGAP28 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP28 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ARHGAP28 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGAP28 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARHGAP28 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ARHGAP28 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ARHGAP28 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in decreased expression of ARHGAP28 mRNA24780913
D012906SmokeSmoke results in decreased expression of ARHGAP28 mRNA21095227
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of ARHGAP28 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARHGAP28 mRNA19933214
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ARHGAP28 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ARHGAP28 mRNA20530235
D014212TretinoinTretinoin results in increased expression of ARHGAP28 mRNA21934132|2372400
D014212TretinoinTretinoin results in increased expression of ARHGAP28 mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of ARHGAP28 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP28 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ARHGAP28 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ARHGAP28 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of ARHGAP28 mRNA24896083
D014638VanadatesVanadates results in decreased expression of ARHGAP28 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ARHGAP28 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005096GTPase activator activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0030833regulation of actin filament polymerization-IBA21873635  
GO:0032956regulation of actin cytoskeleton organization-IBA21873635  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-IBA21873635  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0051497negative regulation of stress fiber assembly-IBA21873635  
GO:0051497negative regulation of stress fiber assembly-IEA-  
GO:1904425negative regulation of GTP binding-IBA21873635  
GO:1904425negative regulation of GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24832863Association of substance dependence phenotypes in the COGA sample. (2015 May)Wetherill LAddict Biol