Gene: CBLL1

79872
HAKAI|RNF188
Cbl proto-oncogene like 1
protein-coding
7q22.3
Ensembl:ENSG00000105879 MIM:606872 Vega:OTTHUMG00000154809 UniprotKB:Q75N03
NC_000007.14
SNP Mapped
10   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.590e-1 (AD)  6.167e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12705421chr7:107760984 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4730258chr7:107755787 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs13226711chr7:107754897 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10280767chr7:107752975 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2188565chr7:107750624 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2023712chr7:107749842 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs13231387chr7:107749534 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6956243chr7:107748466 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10808154chr7:107745951 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7782475chr7:107745806 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP1530.941
ZC3H140.94
CPSF60.94
HECTD10.939
ANKRD170.939
RNF1110.931
KRIT10.931
RPS6KB10.93
USO10.929
PPP1R12A0.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.538
OR4F29-0.506
PLA2G5-0.309
S100A1-0.301
CSAG1-0.298
NKX6-1-0.29
AQP5-0.279
PINLYP-0.274
MDFI-0.269
HMX1-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CBLL1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CBLL1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of CBLL1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of CBLL1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CBLL1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CBLL1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CBLL1 mRNA19770486
D001151ArsenicArsenic affects the methylation of CBLL1 gene25304211
C015001arsenitearsenite results in decreased methylation of CBLL1 promoter23974009
D001280AtrazineAtrazine results in increased expression of CBLL1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CBLL1 mRNA19770486
C006780bisphenol Abisphenol A affects the expression of CBLL1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CBLL1 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in increased expression of CBLL1 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in increased expression of CBLL1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of CBLL1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CBLL1 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of CBLL1 mRNA21621594
C089595cylindrospermopsincylindrospermopsin results in increased expression of CBLL1 mRNA24921660
D003907DexamethasoneDexamethasone results in decreased expression of CBLL1 mRNA21621594
D002945CisplatinCisplatin results in decreased expression of CBLL1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of CBLL1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of CBLL1 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of CBLL1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CBLL1 mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CBLL1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CBLL1 mRNA22079256
C082360fipronilfipronil results in increased expression of CBLL1 mRNA23962444
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CBLL1 mRNA18951874
C544151jinfukangjinfukang results in decreased expression of CBLL1 mRNA27392435
C045463leflunomideleflunomide results in increased expression of CBLL1 mRNA28988120
D008694MethamphetamineMethamphetamine results in increased expression of CBLL1 mRNA19564919
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CBLL1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CBLL1 mRNA23649840
C028007nickel monoxidenickel monoxide results in decreased expression of CBLL1 mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of CBLL1 mRNA18042831
D010634PhenobarbitalPhenobarbital affects the expression of CBLL1 mRNA23091169
D010672PhenytoinPhenytoin results in increased expression of CBLL1 mRNA20345932
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CBLL1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CBLL1 mRNA22079256
D011239PrednisolonePrednisolone results in decreased expression of CBLL1 mRNA21621594
D012715Sesame OilSesame Oil results in decreased expression of CBLL1 mRNA29191790
C009277sodium arsenatesodium arsenate results in decreased expression of CBLL1 mRNA23922661
C016104sodium bichromatesodium bichromate results in increased expression of CBLL1 mRNA25993096
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in decreased expression of CBLL1 mRNA21621594
D016559TacrolimusTacrolimus results in increased expression of CBLL1 mRNA21621594
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CBLL1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CBLL1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBLL1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of CBLL1 mRNA25975270
D013853ThioacetamideThioacetamide results in increased expression of CBLL1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CBLL1 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CBLL1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CBLL1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of CBLL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CBLL1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of CBLL1 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of CBLL1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CBLL1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-ISS-  
GO:0004842ubiquitin-protein transferase activity-TAS14996930  
GO:0005515protein binding-IPI11836526  26871637  
GO:0042802identical protein binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007162negative regulation of cell adhesion-ISS-  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016567protein ubiquitination-IEA-  
GO:0016567protein ubiquitination-TAS14996930  
GO:0030155regulation of cell adhesion-IBA21873635  
GO:0030335positive regulation of cell migration-ISS-  
GO:0035635entry of bacterium into host cell-TAS-  
GO:0045807positive regulation of endocytosis-ISS-  
GO:0080009mRNA methylation-IMP29507755  
GO:0098609cell-cell adhesion-IDA11836526  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IC14996930  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
GO:0016607nuclear speck-IDA-  
GO:0036396RNA N6-methyladenosine methyltransferase complex-IDA29507755  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-8876384Listeria monocytogenes entry into host cellsTAS
R-HSA-8876493InlA-mediated entry of Listeria monocytogenes into host cellsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal