Gene: PLBD1

79887
-
phospholipase B domain containing 1
protein-coding
12p13.1
Ensembl:ENSG00000121316 Vega:OTTHUMG00000168821 UniprotKB:Q6P4A8
NC_000012.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.748e-1 (AD)  4.054e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12425606chr12:14562859 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LILRB20.885
RASGRP40.872
PTPRC0.857
LILRA10.855
ITGAL0.849
MYO1F0.847
SLC7A70.847
TNFAIP80.846
ALPK10.844
MNDA0.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.564
CHRNA4-0.539
BCL11A-0.52
EXTL1-0.519
HAS1-0.516
MYADML2-0.512
NEUROD6-0.509
SLC7A4-0.509
MARCH4-0.507
RTN4R-0.506

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PLBD1 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PLBD1 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLBD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLBD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLBD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLBD1 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of PLBD1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PLBD1 mRNA19770486
C068073Am 580Am 580 results in increased expression of PLBD1 mRNA16982809
D000638AmiodaroneAmiodarone affects the expression of PLBD1 mRNA19483382
D001553BenzbromaroneBenzbromarone affects the expression of PLBD1 mRNA19483382
C006780bisphenol Abisphenol A affects the expression of PLBD1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PLBD1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PLBD1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PLBD1 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PLBD1 promoter22457795
D002737ChloropreneChloroprene results in decreased expression of PLBD1 mRNA23125180
D002994ClofibrateClofibrate results in decreased expression of PLBD1 mRNA17585979
D002994ClofibrateClofibrate affects the expression of PLBD1 mRNA19483382
C093628cyproconazolecyproconazole results in increased expression of PLBD1 mRNA22334560
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PLBD1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PLBD1 mRNA21266533
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of PLBD1 mRNA27638505
D004237DiuronDiuron results in decreased expression of PLBD1 mRNA25152437
C118739entinostatentinostat results in increased expression of PLBD1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLBD1 mRNA"27188386
C109476epoxiconazoleepoxiconazole results in increased expression of PLBD1 mRNA22334560
D005001EthionineEthionine affects the expression of PLBD1 mRNA19483382
C419708gefitinibPLBD1 protein affects the susceptibility to gefitinib15496427
C016517indole-3-carbinolindole-3-carbinol affects the expression of PLBD1 mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLBD1 mRNA23086925|2479639
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PLBD1 mRNA23179753
C523799MRK 003PLBD1 results in increased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in increased expression of PLBD1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PLBD1 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of PLBD1 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of PLBD1 mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of PLBD1 mRNA19483382
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLBD1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PLBD1 mRNA26272509
D052638Particulate MatterParticulate Matter results in increased expression of PLBD1 mRNA22178795
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PLBD1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PLBD1 mRNA20813756|2381119
C006253pirinixic acidpirinixic acid affects the expression of PLBD1 mRNA19483382
D011374ProgesteroneProgesterone results in decreased expression of PLBD1 mRNA23012394
C045950propiconazolepropiconazole results in increased expression of PLBD1 mRNA21278054|2233456
D011441PropylthiouracilPropylthiouracil affects the expression of PLBD1 mRNA19483382
C089730rosiglitazonerosiglitazone results in increased expression of PLBD1 mRNA16982809
D012969Sodium FluorideSodium Fluoride results in increased expression of PLBD1 protein28918527
D053260SootSoot affects the expression of PLBD1 mRNA26551751
C501413tesaglitazartesaglitazar results in increased expression of PLBD1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLBD1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLBD1 mRNA26232522
D013853ThioacetamideThioacetamide affects the expression of PLBD1 mRNA19483382
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PLBD1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PLBD1 protein27818348
D014212TretinoinTretinoin results in increased expression of PLBD1 mRNA21934132
C080163trovafloxacintrovafloxacin results in decreased expression of PLBD1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of PLBD1 mRNA29154799
D014638VanadatesVanadates results in decreased expression of PLBD1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PLBD1 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of PLBD1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004622lysophospholipase activity-TAS-  
GO:0004623phospholipase A2 activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006644phospholipid metabolic process-TAS-  
GO:0016042lipid catabolic process-IEA-  
GO:0036149phosphatidylinositol acyl-chain remodeling-TAS-  
GO:0036151phosphatidylcholine acyl-chain remodeling-TAS-  
GO:0036152phosphatidylethanolamine acyl-chain remodeling-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA25645918  
GO:0005764lysosome-IEA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482788Acyl chain remodelling of PCTAS
R-HSA-1482839Acyl chain remodelling of PETAS
R-HSA-1482922Acyl chain remodelling of PITAS
R-HSA-1483115Hydrolysis of LPCTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal