Gene: ATP8B4

79895
ATPIM
ATPase phospholipid transporting 8B4 (putative)
protein-coding
15q21.2
Ensembl:ENSG00000104043 MIM:609123 Vega:OTTHUMG00000172368 UniprotKB:Q8TF62
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.285e-1 (AD)  1.298e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8024393chr15:50060690 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00868652chr15:50411535ATP8B4Promoter5.332e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTK0.903
NCKAP1L0.895
TLR10.89
CLEC7A0.886
DOCK20.885
SYK0.881
CD860.879
HLA-DOA0.875
C3AR10.875
PTPRC0.875

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.41
ATP2C2-0.385
HES5-0.378
WNT7A-0.371
HES6-0.365
HAGHL-0.359
MAGIX-0.353
KCNIP3-0.352
ARSF-0.352
C9orf24-0.348

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP8B4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP8B4 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATP8B4 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of ATP8B4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ATP8B4 mRNA26079696
D002104CadmiumCadmium results in decreased expression of ATP8B4 mRNA24376830
D003561CytarabineCytarabine results in decreased expression of ATP8B4 mRNA21198554
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ATP8B4 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ATP8B4 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATP8B4 mRNA]17942915
C118739entinostatentinostat results in increased expression of ATP8B4 mRNA27188386
D007213IndomethacinIndomethacin results in increased expression of ATP8B4 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ATP8B4 mRNA25613284
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ATP8B4 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ATP8B4 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of ATP8B4 mRNA20880076
D052638Particulate MatterParticulate Matter results in decreased expression of ATP8B4 mRNA22178795
D010634PhenobarbitalPhenobarbital affects the expression of ATP8B4 mRNA23091169
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ATP8B4 mRNA25895662
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ATP8B4 mRNA25613284
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of ATP8B4 mRNA28666766
D014520UrethaneUrethane results in decreased expression of ATP8B4 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ATP8B4 mRNA28001369
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATP8B4 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of ATP8B4 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004012phospholipid-translocating ATPase activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007030Golgi organization-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0045332phospholipid translocation-IBA21873635  
GO:0045332phospholipid translocation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IBA21873635  
GO:0005794Golgi apparatus-IDA20947505  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA20947505  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0035579specific granule membrane-TAS-  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal