Gene: SYNDIG1

79953
C20orf39|DSPC2|IFITMD5|TMEM90B
synapse differentiation inducing 1
protein-coding
20p11.21
Ensembl:ENSG00000101463 MIM:614311 Vega:OTTHUMG00000032104 UniprotKB:Q9H7V2
NC_000020.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.221e-1 (AD)  2.615e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6049811chr20:24609154 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
APBA20.941
GFRA20.923
LINGO10.92
FSD10.917
DOC2A0.915
STX1A0.915
CHGA0.913
SYNGR30.908
HR0.908
UBE2QL10.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.537
OR4F5-0.53
OR4F29-0.501
PARD3B-0.49
ARHGEF5-0.484
CDC14A-0.469
RBPMS-0.469
REST-0.463
ASB4-0.46
SH2D4A-0.45

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of SYNDIG1 mRNA28959563
C015001arsenitearsenite results in increased methylation of SYNDIG1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of SYNDIG1 mRNA25929836
C547126AZM551248AZM551248 results in increased expression of SYNDIG1 mRNA22323515
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of SYNDIG1 mRNA20404318
C006780bisphenol Abisphenol A results in increased methylation of SYNDIG1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SYNDIG1 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of SYNDIG1 mRNA26577399
D003976DiazinonDiazinon results in increased methylation of SYNDIG1 gene22964155
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SYNDIG1 mRNA27405655
C039281furanfuran results in increased expression of SYNDIG1 mRNA27387713
C544151jinfukangjinfukang results in increased expression of SYNDIG1 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SYNDIG1 mRNA28001369
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of SYNDIG1 mRNA29162477
D011374ProgesteroneProgesterone results in decreased expression of SYNDIG1 mRNA19690047
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SYNDIG1 mRNA25895662
D012999SomanSoman results in decreased expression of SYNDIG1 mRNA19281266
D014635Valproic AcidValproic Acid results in decreased expression of SYNDIG1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of SYNDIG1 mRNA27188386
D014810Vitamin EVitamin E results in increased expression of SYNDIG1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0035254glutamate receptor binding-ISS-  
GO:0042803protein homodimerization activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-ISS-  
GO:0009607response to biotic stimulus-IEA-  
GO:0051965positive regulation of synapse assembly-IDA20152115  
GO:0097091synaptic vesicle clustering-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-ISS-  
GO:0014069postsynaptic density-ISS-  
GO:0030054cell junction-IEA-  
GO:0031901early endosome membrane-ISS-  
GO:0043197dendritic spine-ISS-  
GO:0043198dendritic shaft-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0044297cell body-ISS-  
GO:0045211postsynaptic membrane-IEA-  
GO:0060076excitatory synapse-ISS-  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal