Gene: GLRA3

8001
-
glycine receptor alpha 3
protein-coding
4q34.1
Ensembl:ENSG00000145451 MIM:600421 Vega:OTTHUMG00000149816 UniprotKB:O75311
NC_000004.12
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.961e-1 (AD)  1.006e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6824735chr4:174819418 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDST30.912
LRRTM40.911
NOL40.91
CBLN40.908
SLC2A130.906
CNR10.901
DGKB0.9
CACNA2D10.898
GRIA40.896
OLFM30.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.592
HEY2-0.562
HEYL-0.539
FAM114A1-0.537
MAGEA12-0.529
GJA4-0.524
CPM-0.522
RNF135-0.521
CHST14-0.52
MYL3-0.518

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB00431LindaneSmall Molecule58-89-9Approved|WithdrawnTarget
DB00466PicrotoxinSmall Molecule124-87-8ExperimentalTarget
DB00602IvermectinSmall Molecule70288-86-7Approved|InvestigationalTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GLRA3 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GLRA3 mRNA21298039
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GLRA3 mRNA19619570
D004958EstradiolEstradiol results in increased expression of GLRA3 mRNA19619570
C095105bexarotenebexarotene results in increased expression of GLRA3 mRNA16648578
C006780bisphenol Abisphenol A results in decreased expression of GLRA3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GLRA3 promoter22457795
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GLRA3 mRNA23914054
D000431EthanolEthanol results in decreased expression of GLRA3 mRNA20655511
D018683Excitatory Amino Acid AgentsDinoprostone inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]]15131310
D018683Excitatory Amino Acid AgentsExcitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]15131310
C082360fipronilfipronil results in decreased activity of GLRA3 protein22035056
D005620Freund's AdjuvantGLRA3 results in increased susceptibility to Freund's Adjuvant15131310
C008261lead acetatelead acetate results in decreased expression of GLRA3 mRNA22641619
D001556LindaneLindane results in decreased activity of GLRA3 protein22035056
D008627Mercuric ChlorideMercuric Chloride affects the expression of GLRA3 mRNA20353558
D008628MercuryMercury results in increased expression of GLRA3 mRNA16823088
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GLRA3 mRNA21385734
D008777MethyltestosteroneMethyltestosterone results in decreased expression of GLRA3 mRNA29191790
D015232DinoprostoneDinoprostone inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]]15131310
D015232DinoprostoneGLRA3 results in increased susceptibility to Dinoprostone15131310
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GLRA3 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in increased expression of GLRA3 mRNA24780913
C017947sodium arsenitesodium arsenite results in increased expression of GLRA3 mRNA17879257
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GLRA3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLRA3 mRNA19619570
D014635Valproic AcidValproic Acid affects the expression of GLRA3 mRNA17292431
D015054ZymosanGLRA3 results in increased susceptibility to Zymosan15131310

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005254chloride channel activityCONTRIBUTES_TOIBA21873635  
GO:0016594glycine bindingCONTRIBUTES_TOIBA21873635  
GO:0016934extracellularly glycine-gated chloride channel activityCONTRIBUTES_TOIBA21873635  
GO:0016934extracellularly glycine-gated chloride channel activity-IDA26416729  
GO:0022852glycine-gated chloride ion channel activity-IDA9677400  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0043200response to amino acid-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0051260protein homooligomerization-IDA26416729  
GO:0060012synaptic transmission, glycinergic-IBA21873635  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:1902476chloride transmembrane transport-IBA21873635  
GO:1902476chloride transmembrane transport-IDA9677400  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA26416729  
GO:0005887integral component of plasma membrane-IMP9677400  
GO:0016935glycine-gated chloride channel complex-IDA9677400  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043204perikaryon-IEA-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23239122Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans. (2013 Apr)Han SHum Genet