Gene: NAA25

80018
C12orf30|MDM20|NAP1
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
protein-coding
12q24.13
Ensembl:ENSG00000111300 MIM:612755 Vega:OTTHUMG00000169638 UniprotKB:Q14CX7
NG_017071.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.166e-2 (AD)  2.799e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3825388chr12:112048147 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNT20.934
ATG2B0.928
MON20.926
DCUN1D40.922
TCERG10.92
DDI20.919
RPS6KB10.913
GPALPP10.912
USP480.908
UBA60.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.476
OR4F29-0.434
MTRNR2L10-0.357
MTRNR2L9-0.351
PLA2G5-0.347
S100A1-0.345
MTRNR2L6-0.34
MTRNR2L2-0.327
RHOD-0.318
HIGD1B-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NAA25 mRNA"27291303
D000082AcetaminophenAcetaminophen results in decreased expression of NAA25 mRNA21420995
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NAA25 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NAA25 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of NAA25 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of NAA25 promoter22457795
D019327Copper SulfateCopper Sulfate results in increased expression of NAA25 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of NAA25 mRNA20106945|2798913
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NAA25 protein23301498
D005557FormaldehydeFormaldehyde results in decreased expression of NAA25 mRNA20655997
D017313FenretinideFenretinide results in increased expression of NAA25 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NAA25 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of NAA25 mRNA27392435
C011890kojic acidkojic acid results in increased expression of NAA25 mRNA16595896
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NAA25 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NAA25 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NAA25 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NAA25 mRNA"25554681
D009532NickelNickel results in increased expression of NAA25 mRNA25583101
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of NAA25 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of NAA25 mRNA23012394
C045950propiconazolepropiconazole results in increased expression of NAA25 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of NAA25 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NAA25 mRNA21632981
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NAA25 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of NAA25 mRNA27760801
C012589trichostatin Atrichostatin A results in increased expression of NAA25 mRNA26272509
D014635Valproic AcidValproic Acid results in decreased expression of NAA25 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased expression of NAA25 mRNA29154799
D014750VincristineVincristine results in decreased expression of NAA25 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004596peptide alpha-N-acetyltransferase activityCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0017196N-terminal peptidyl-methionine acetylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0031416NatB complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal