Gene: BICC1

80114
BICC|CYSRD
BicC family RNA binding protein 1
protein-coding
10q21.1
Ensembl:ENSG00000122870 MIM:614295 Vega:OTTHUMG00000018271 UniprotKB:Q9H694
NG_029759.2
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.935e-2 (AD)  3.766e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7101281chr10:58661978 (GRCh38.p7)T>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAST40.804
DPP80.798
NR3C20.796
ATL20.791
PBX10.789
TMEM560.789
PPM1L0.787
FOXO30.786
ARHGAP320.786
NRXN10.785

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG8-0.441
ACAP1-0.409
MDFI-0.397
TGFB3-0.387
SGMS2-0.384
KLRK1-0.381
BCL7C-0.379
MYL3-0.378
SH2D1A-0.378
PGF-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of BICC1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BICC1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BICC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BICC1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BICC1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of BICC1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of BICC1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BICC1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BICC1 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BICC1 mRNA23630614
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BICC1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BICC1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BICC1 mRNA22300585
D004958EstradiolEstradiol results in increased expression of BICC1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of BICC1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of BICC1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of BICC1 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BICC1 mRNA20938992
D003300CopperCopper deficiency results in increased expression of BICC1 mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of BICC1 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased methylation of BICC1 promoter27989131
D016572CyclosporineCyclosporine results in decreased expression of BICC1 mRNA19770486
D003907DexamethasoneDexamethasone results in decreased expression of BICC1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BICC1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of BICC1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of BICC1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of BICC1 mRNA18042831|2501614
D004041Dietary FatsDietary Fats results in increased expression of BICC1 mRNA22609946
D019422Dietary SucroseDietary Sucrose results in increased expression of BICC1 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of BICC1 mRNA24535843
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of BICC1 mRNA"27840820
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BICC1 mRNA20938992
D017313FenretinideFenretinide results in increased expression of BICC1 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of BICC1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of BICC1 mRNA27392435
C045463leflunomideleflunomide results in increased expression of BICC1 mRNA28988120
D008558MelphalanMelphalan results in decreased expression of BICC1 mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BICC1 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BICC1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of BICC1 promoter"26251327
D009532NickelNickel results in increased expression of BICC1 mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of BICC1 mRNA22714537
D009966OrphenadrineOrphenadrine affects the expression of BICC1 mRNA23665939
D000073878Palm OilPalm Oil results in decreased expression of BICC1 mRNA18042831
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BICC1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of BICC1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BICC1 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BICC1 mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in increased expression of BICC1 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of BICC1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in increased expression of BICC1 mRNA25351596
D012834SilverSilver results in decreased expression of BICC1 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BICC1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BICC1 mRNA19770486
D013853ThioacetamideThioacetamide results in increased expression of BICC1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of BICC1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BICC1 mRNA28065790
C057693troglitazonetroglitazone results in decreased expression of BICC1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BICC1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of BICC1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of BICC1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of BICC1 mRNA23179753|2438349
D014640VancomycinVancomycin results in decreased expression of BICC1 mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO ID GO Term Qualifier Evidence PubMed
GO:0007368determination of left/right symmetry-IEA-  
GO:0007507heart development-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA21922595  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal