Gene: FHOD3

80206
FHOS2|Formactin2
formin homology 2 domain containing 3
protein-coding
18q12.2
Ensembl:ENSG00000134775 MIM:609691 Vega:OTTHUMG00000182381 UniprotKB:Q2V2M9
NG_042837.1
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.627e-1 (AD)  7.777e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs878913chr18:36454768 (GRCh38.p7)C>G / C>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19586143chr18:34325134FHOD31.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC40.956
MYH100.952
AMIGO10.951
KALRN0.948
RAB6B0.947
TOMM40L0.947
ADARB10.945
RBFOX20.943
DCAF60.942
INPP4A0.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.536
HEY2-0.534
REST-0.532
WWTR1-0.524
YES1-0.513
SGMS2-0.512
SH2D1A-0.508
RAB13-0.506
CNN2-0.504
CSAG1-0.503

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FHOD3 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of FHOD3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FHOD3 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FHOD3 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FHOD3 mRNA24449571
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of FHOD3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FHOD3 mRNA19770486|2071347
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FHOD3 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of FHOD3 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of FHOD3 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of FHOD3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FHOD3 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of FHOD3 mRNA15336504
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of FHOD3 mRNA26272509
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FHOD3 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FHOD3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FHOD3 mRNA19561079
D004041Dietary FatsDietary Fats results in decreased expression of FHOD3 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of FHOD3 mRNA16002434
C071834glycidamideglycidamide results in decreased expression of FHOD3 mRNA17822822
D017313FenretinideFenretinide results in increased expression of FHOD3 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of FHOD3 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FHOD3 mRNA27392435
C544151jinfukangjinfukang results in increased expression of FHOD3 mRNA27392435
D007854LeadLead affects the splicing of FHOD3 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of FHOD3 mRNA28988120
C042720mercuric bromidemercuric bromide results in decreased expression of FHOD3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C014085methotrexate polyglutamateFHOD3 gene affects the abundance of methotrexate polyglutamate19066393
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FHOD3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FHOD3 mRNA23649840
C523799MRK 003FHOD3 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FHOD3 mRNA"25620056
D009532NickelNickel results in decreased expression of FHOD3 mRNA24768652|2558310
D010100OxygenOxygen deficiency results in decreased expression of FHOD3 mRNA20880076
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of FHOD3 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FHOD3 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FHOD3 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of FHOD3 mRNA20864642
C005556propionaldehydepropionaldehyde results in increased expression of FHOD3 mRNA26079696
C502851quinocetonequinocetone results in increased expression of FHOD3 mRNA27046791
D012643SeleniumSelenium results in decreased expression of FHOD3 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FHOD3 mRNA25351596
D012834SilverSilver results in decreased expression of FHOD3 mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FHOD3 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FHOD3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FHOD3 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FHOD3 mRNA19465110
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FHOD3 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of FHOD3 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FHOD3 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of FHOD3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of FHOD3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of FHOD3 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FHOD3 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FHOD3 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of FHOD3 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI21149568  
GO ID GO Term Qualifier Evidence PubMed
GO:0030837negative regulation of actin filament polymerization-IEA-  
GO:0045214sarcomere organization-IEA-  
GO:0051639actin filament network formation-IEA-  
GO:0055003cardiac myofibril assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005865striated muscle thin filament-IEA-  
GO:0030018Z disc-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal