Gene: WDR61

80349
REC14|SKI8
WD repeat domain 61
protein-coding
15q25.1
Ensembl:ENSG00000140395 MIM:609540 Vega:OTTHUMG00000143735 UniprotKB:Q9GZS3
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.250e-1 (AD)  4.703e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7173851chr15:78286317 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKAG10.951
NFU10.939
KHDRBS10.938
PDCD60.937
PWP10.934
APEX10.933
MRPS230.933
PSMC20.933
CDC420.93
ACTR100.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.705
OR4F29-0.672
MTRNR2L6-0.384
MTRNR2L9-0.368
MTRNR2L10-0.33
PPBP-0.28
TTLL10-0.262
MTRNR2L2-0.26
P2RY14-0.26
MTRNR2L8-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of WDR61 mRNA19933214
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of WDR61 mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of WDR61 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of WDR61 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of WDR61 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of WDR61 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of WDR61 mRNA19770486
D001280AtrazineAtrazine results in decreased expression of WDR61 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WDR61 mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WDR61 mRNA21839799
C006780bisphenol Abisphenol A affects the expression of WDR61 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WDR61 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of WDR61 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of WDR61 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of WDR61 gene28505145
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of WDR61 mRNA28472532
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of WDR61 mRNA17602206
D019327Copper SulfateCopper Sulfate results in decreased expression of WDR61 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of WDR61 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WDR61 mRNA28628672
D002945CisplatinCisplatin results in increased expression of WDR61 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of WDR61 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of WDR61 mRNA17602206
D004317DoxorubicinWDR61 protein affects the susceptibility to Doxorubicin16217747
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of WDR61 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of WDR61 mRNA17555576
D018120FinasterideFinasteride results in increased expression of WDR61 mRNA24136188
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of WDR61 mRNA]15016801
D005485FlutamideFlutamide results in increased expression of WDR61 mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WDR61 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of WDR61 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WDR61 mRNA28628672
C410337K 7174K 7174 results in decreased expression of WDR61 mRNA24086573
D007854LeadLead results in increased expression of WDR61 mRNA19921347
D008748MethylcholanthreneMethylcholanthrene results in increased expression of WDR61 mRNA20713471
C051752nefazodonenefazodone results in increased expression of WDR61 mRNA24136188
D017239PaclitaxelWDR61 protein affects the susceptibility to Paclitaxel16217747
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of WDR61 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of WDR61 mRNA22079256|2271453
D011794QuercetinQuercetin results in decreased expression of WDR61 mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of WDR61 mRNA20436886
D012999SomanSoman results in decreased expression of WDR61 mRNA19281266
D013467SulindacSulindac results in decreased expression of WDR61 mRNA24136188
D013629TamoxifenTamoxifen affects the expression of WDR61 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WDR61 mRNA21570461
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of WDR61 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of WDR61 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of WDR61 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of WDR61 gene25560391
D014747VinblastineWDR61 protein affects the susceptibility to Vinblastine16217747
C111237vorinostatvorinostat results in decreased expression of WDR61 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16024656  20178742  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-TAS-  
GO:0006368transcription elongation from RNA polymerase II promoter-TAS-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0016567protein ubiquitination-TAS-  
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter-IDA20178742  
GO:0043928exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay-TAS-  
GO:0045638negative regulation of myeloid cell differentiation-IDA20541477  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA20178742  
GO:0051571positive regulation of histone H3-K4 methylation-IMP16024656  
GO:0080182histone H3-K4 trimethylation-IMP16024656  
GO:2001162positive regulation of histone H3-K79 methylation-IMP16024656  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16024656  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA16024656  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016593Cdc73/Paf1 complex-IDA20178742  
GO:0035327transcriptionally active chromatin-IDA16024656  
GO:0055087Ski complex-IDA16024656  
KEGG ID KEGG Term
hsa03018RNA degradation
Reactome ID Reactome Term Evidence
R-HSA-112382Formation of RNA Pol II elongation complex TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-429914Deadenylation-dependent mRNA decayTAS
R-HSA-429958mRNA decay by 3' to 5' exoribonucleaseTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-674695RNA Polymerase II Pre-transcription EventsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75955RNA Polymerase II Transcription ElongationTAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteinsTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal