Gene: ADAM12

8038
ADAM12-OT1|CAR10|MCMP|MCMPMltna|MLTN|MLTNA
ADAM metallopeptidase domain 12
protein-coding
10q26.2
Ensembl:ENSG00000148848 MIM:602714 Vega:OTTHUMG00000019243 UniprotKB:O43184
NG_029050.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.619e-2 (AD)  4.225e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10794077chr10:126282489 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD440.719
TMEM39A0.685
POU4F10.679
RNF2170.676
FZD50.672
SPOCD10.669
HAP10.665
ASCC30.665
PTX30.661
ATP11A0.661

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PVALB-0.366
LRRC38-0.33
BHLHA9-0.328
NEUROD6-0.327
SLC7A4-0.325
EIF4E1B-0.315
KIT-0.309
PAH-0.309
RAB37-0.307
LYPD8-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM12 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM12 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM12 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM12 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM12 mRNA"25510870
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of ADAM12 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAM12 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAM12 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAM12 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of ADAM12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAM12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAM12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAM12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of ADAM12 mRNA"27188386
C015001arsenitearsenite results in increased methylation of ADAM12 promoter23974009
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of ADAM12 mRNA15894712
C015001arsenitearsenite results in decreased expression of ADAM12 mRNA15894712
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of ADAM12 protein18360054
C487081belinostatbelinostat results in decreased expression of ADAM12 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAM12 mRNA"27188386
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of ADAM12 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADAM12 mRNA15894712
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ADAM12 mRNA19406945
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of ADAM12 mRNA17404688
C006780bisphenol Abisphenol A results in increased expression of ADAM12 mRNA24586524
C018475butyraldehydebutyraldehyde results in decreased expression of ADAM12 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADAM12 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ADAM12 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADAM12 mRNA19376846
D005576ColforsinColforsin results in decreased expression of ADAM12 mRNA15313392|1596741
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADAM12 mRNA16054899
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of ADAM12 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ADAM12 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ADAM12 mRNA27392435
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of ADAM12 mRNA26159488
C118739entinostatentinostat results in decreased expression of ADAM12 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAM12 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ADAM12 gene20938992
D017313FenretinideFenretinide results in decreased expression of ADAM12 mRNA28973697
D006854HydrocortisoneHydrocortisone results in decreased expression of ADAM12 mRNA21267416
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAM12 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADAM12 mRNA16054899
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ADAM12 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADAM12 mRNA23430699
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ADAM12 gene20938992
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of ADAM12 mRNA19812364
D009532NickelNickel results in increased expression of ADAM12 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of ADAM12 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of ADAM12 mRNA22714537
D010100OxygenOxygen deficiency results in increased expression of ADAM12 mRNA26516004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAM12 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of ADAM12 mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM12 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ADAM12 mRNA26705709
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ADAM12 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of ADAM12 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ADAM12 mRNA19406945
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of ADAM12 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of ADAM12 mRNA21795739
D011374ProgesteroneProgesterone affects the expression of ADAM12 mRNA17251523
D011794QuercetinQuercetin results in increased expression of ADAM12 mRNA15309432
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADAM12 mRNA16054899
C010327salinomycinsalinomycin results in decreased expression of ADAM12 mRNA19682730
D012834SilverSilver results in decreased expression of ADAM12 mRNA27131904
D018038Sodium SeleniteSodium Selenite results in decreased expression of ADAM12 mRNA18175754
D014284TriiodothyronineTriiodothyronine results in increased expression of ADAM12 mRNA23397585
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of ADAM12 mRNA26159488
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ADAM12 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ADAM12 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAM12 mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of ADAM12 mRNA"19682533
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of ADAM12 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ADAM12 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of ADAM12 mRNA24935251|2627250
C057693troglitazonetroglitazone results in increased expression of ADAM12 mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of ADAM12 mRNA19101580
D014635Valproic AcidValproic Acid results in increased methylation of ADAM12 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ADAM12 mRNA17963808
D014638VanadatesVanadates results in increased expression of ADAM12 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ADAM12 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ADAM12 mRNA23555832
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ADAM12 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IEA-  
GO:0005515protein binding-IPI15280379  
GO:0008237metallopeptidase activity-TAS9417060  
GO:0017124SH3 domain binding-IPI15280379  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007520myoblast fusion-TAS7566181  
GO:0030198extracellular matrix organization-TAS-  
GO:0045766positive regulation of angiogenesis-IMP28637396  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-IDA15280379  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionIEA
R-HSA-177929Signaling by EGFRIEA
R-HSA-8941237Invadopodia formationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19003798First trimester maternal serum PAPP-A, beta-hCG and ADAM12 in prediction of small-for-gestational-age fetuses. (2008 Dec)Pihl KPrenat Diagn
26105301OS087. Maternal characteristics, mean arterial pressure and PLGF in early prediction of preeclampsia. (2012 Jul)Kuc SPregnancy Hypertens
21257082Screening for pre-eclampsia--lessons from aneuploidy screening. (2011 Feb)Cuckle HSPlacenta