Gene: ACAD10

80724
-
acyl-CoA dehydrogenase family member 10
protein-coding
12q24.12
Ensembl:ENSG00000111271 MIM:611181 Vega:OTTHUMG00000169602 UniprotKB:Q6JQN1
NC_000012.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.334e-1 (AD)  7.630e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11066019chr12:111746083 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11066015chr12:111730205 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GOLGA10.816
VPS520.815
NRBP20.813
TAB10.808
AKT20.808
KDM3B0.799
NUMA10.799
TK20.799
C20orf1940.795
PHKA20.794

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.637
OR4F29-0.596
ODAM-0.308
FOXB1-0.259
OTP-0.255
SIM1-0.255
HCRT-0.254
NANOGNB-0.253
C22orf42-0.252
HMX2-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of ACAD10 mRNA28329830
D000082AcetaminophenAcetaminophen affects the expression of ACAD10 mRNA17562736
D000393Air PollutantsAir Pollutants analog results in decreased expression of ACAD10 mRNA21757418
D000638AmiodaroneAmiodarone results in increased expression of ACAD10 mRNA24535564
D001280AtrazineAtrazine results in decreased expression of ACAD10 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of ACAD10 mRNA22323515
C006780bisphenol Abisphenol A results in increased methylation of ACAD10 promoter27312807
C006780bisphenol Abisphenol A affects the expression of ACAD10 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ACAD10 mRNA26079696
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ACAD10 mRNA28472532
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of ACAD10 protein26984711
D004041Dietary FatsDietary Fats affects the expression of ACAD10 mRNA19680557
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ACAD10 mRNA]"23626681
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of ACAD10 mRNA27638505
D004317DoxorubicinDoxorubicin affects the expression of ACAD10 mRNA26873546
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of ACAD10 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of ACAD10 mRNA24136188
C039281furanfuran results in decreased expression of ACAD10 mRNA26194646
D005897GlafenineGlafenine results in decreased expression of ACAD10 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACAD10 mRNA25613284
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ACAD10 mRNA"26251327
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ACAD10 mRNA20936131
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ACAD10 mRNA]"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ACAD10 mRNA18467677|2093613
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACAD10 mRNA]18467677|2093613
C006253pirinixic acidpirinixic acid results in increased expression of ACAD10 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of ACAD10 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of ACAD10 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of ACAD10 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ACAD10 mRNA27029645
C089730rosiglitazonerosiglitazone affects the expression of ACAD10 mRNA22013433
C016104sodium bichromatesodium bichromate results in decreased expression of ACAD10 mRNA25993096
C013698tallowtallow affects the expression of ACAD10 mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACAD10 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACAD10 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of ACAD10 mRNA23411599
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ACAD10 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ACAD10 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ACAD10 mRNA24535564
D014640VancomycinVancomycin results in increased expression of ACAD10 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ACAD10 gene25560391
C111237vorinostatvorinostat results in decreased expression of ACAD10 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003995acyl-CoA dehydrogenase activity-TAS-  
GO:0016787hydrolase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006635fatty acid beta-oxidation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-NAS21237683  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-77289Mitochondrial Fatty Acid Beta-OxidationTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal