Gene: GRIP2

80852
-
glutamate receptor interacting protein 2
protein-coding
3p25.1
Ensembl:ENSG00000144596 Vega:OTTHUMG00000155544 UniprotKB:Q9C0E4
NC_000003.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.701e-1 (AD)  5.326e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs872526chr3:14519332 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANK10.904
SLC32A10.885
GAD10.879
TMEM151B0.879
KCNQ40.873
BTBD110.872
LHX60.872
ZNF385D0.871
VWC20.869
N4BP30.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEBP2-0.571
ROM1-0.561
REST-0.56
ACTL6A-0.553
S100A12-0.544
CBFB-0.543
CLEC4E-0.541
AGTRAP-0.54
S100A8-0.535
RAB13-0.535

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRIP2 mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of GRIP2 mRNA"23829299
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GRIP2 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GRIP2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRIP2 mRNA16483693
C006780bisphenol Abisphenol A affects the expression of GRIP2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of GRIP2 mRNA26079696
D003042CocaineCocaine results in increased expression of GRIP2 mRNA16076954
D003300CopperCopper deficiency results in increased expression of GRIP2 mRNA26033743
D013759DronabinolDronabinol results in decreased expression of GRIP2 mRNA17578508
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GRIP2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of GRIP2 mRNA27392435
D000431EthanolEthanol results in increased expression of GRIP2 mRNA20655511
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GRIP2 mRNA27392435
D007854LeadLead affects the expression of GRIP2 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of GRIP2 mRNA"24972896
D008694MethamphetamineMethamphetamine results in increased expression of GRIP2 mRNA26307267
C410127PCB 180PCB 180 results in increased expression of GRIP2 mRNA23829299
D014635Valproic AcidValproic Acid results in increased methylation of GRIP2 gene29154799
C088658zoledronic acidzoledronic acid results in increased expression of GRIP2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030159receptor signaling complex scaffold activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal