Gene: DPF3

8110
BAF45C|CERD4
double PHD fingers 3
protein-coding
14q24.2
Ensembl:ENSG00000205683 MIM:601672 Vega:OTTHUMG00000171364 UniprotKB:Q92784
NC_000014.9
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.591e-3 (AD)  4.445e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2526919chr14:72641063 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04122918chr14:73146313DPF3Gene body5.781e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGFR20.838
DDR10.833
PLXNB10.825
MTMR100.825
ZHX20.824
PHGDH0.821
FBXL70.802
NKX2-20.801
LLGL10.8
MEGF100.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC68-0.488
OSBPL10-0.481
CACNA1F-0.468
GRM8-0.466
KCNH5-0.466
KCNS2-0.461
PRSS12-0.453
TPBG-0.45
CDH7-0.45
PTPN3-0.446

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of DPF3 mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of DPF3 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of DPF3 mRNA"23829299
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DPF3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DPF3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DPF3 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DPF3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DPF3 mRNA20064835|2187194
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DPF3 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of DPF3 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of DPF3 mRNA26079696
D002104CadmiumCadmium results in decreased expression of DPF3 mRNA24376830
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DPF3 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DPF3 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of DPF3 mRNA24386269
D003520CyclophosphamideCyclophosphamide results in decreased expression of DPF3 mRNA27281708
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DPF3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DPF3 mRNA27392435
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DPF3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DPF3 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DPF3 gene20938992
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DPF3 mRNA24763279
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DPF3 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DPF3 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DPF3 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DPF3 mRNA"26251327
D009532NickelNickel results in decreased expression of DPF3 mRNA24768652|2558310
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DPF3 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of DPF3 mRNA25729387
D012906SmokeSmoke results in increased expression of DPF3 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of DPF3 gene28589171
D012999SomanSoman results in decreased expression of DPF3 mRNA19281266
D053260SootSoot results in increased expression of DPF3 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DPF3 mRNA22298810
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of DPF3 mRNA]16891777
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DPF3 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DPF3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DPF3 mRNA16891777
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DPF3 mRNA25729387
D019772TopotecanTopotecan affects the expression of DPF3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of DPF3 mRNA21934132
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DPF3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of DPF3 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of DPF3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of DPF3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0004402histone acetyltransferase activity-IBA21873635  
GO:0008270zinc ion binding-NAS8812431  
GO:0042393histone binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0007399nervous system development-IBA21873635  
GO:0007399nervous system development-IEA-  
GO:0008150biological_process-ND-  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000123histone acetyltransferase complex-IBA21873635  
GO:0000790nuclear chromatin-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0071565nBAF complex-IBA21873635  
GO:0071565nBAF complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res