Gene: SGPP1

81537
SPPase1
sphingosine-1-phosphate phosphatase 1
protein-coding
14q23.2
Ensembl:ENSG00000126821 MIM:612826 Vega:OTTHUMG00000029080 UniprotKB:Q9BX95
NC_000014.9
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.524e-1 (AD)  8.408e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11845765chr14:63725032 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS37A0.939
KPNA30.939
RAB180.938
MAP4K30.929
TMEM106B0.923
TBK10.922
DEGS10.921
UBA30.92
EIF1AX0.919
C5orf240.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.63
OR4F29-0.563
CSAG1-0.322
MTRNR2L6-0.317
MTRNR2L10-0.314
MTRNR2L9-0.313
TTLL10-0.287
RNF223-0.264
MTRNR2L2-0.263
MTRNR2L3-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SGPP1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SGPP1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SGPP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP1 mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of SGPP1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SGPP1 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SGPP1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SGPP1 mRNA16483693
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of SGPP1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SGPP1 mRNA15034205
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of SGPP1 mRNA26496021
D001663BilirubinBilirubin results in decreased expression of SGPP1 mRNA20196124
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of SGPP1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of SGPP1 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of SGPP1 mRNA20977926
D002065BuspironeBuspirone results in increased expression of SGPP1 mRNA24136188
D002104CadmiumCadmium results in increased expression of SGPP1 mRNA24376830
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SGPP1 mRNA17602206
C029892cupric chloridecupric chloride results in decreased expression of SGPP1 mRNA24650576
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of SGPP1 mRNA16963248
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of SGPP1 protein23811945
D003976DiazinonDiazinon affects the expression of SGPP1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SGPP1 mRNA17361019|2126653
D002945CisplatinCisplatin results in decreased expression of SGPP1 mRNA27392435
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of SGPP1 mRNA18313992
D004026DieldrinDieldrin affects the expression of SGPP1 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of SGPP1 mRNA19030233
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SGPP1 mRNA17602206
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SGPP1 mRNA19638242
D004237DiuronDiuron results in decreased expression of SGPP1 mRNA25152437
D005485FlutamideFlutamide results in decreased expression of SGPP1 mRNA19442681
D005485FlutamideFlutamide results in decreased expression of SGPP1 mRNA24793618
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of SGPP1 mRNA16963248
D005897GlafenineGlafenine results in decreased expression of SGPP1 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of SGPP1 mRNA22634610
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of SGPP1 mRNA16963248
D017313FenretinideFenretinide results in decreased expression of SGPP1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of SGPP1 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SGPP1 mRNA24796395
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SGPP1 mRNA23179753|2800136
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SGPP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SGPP1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SGPP1 mRNA19812364
C051752nefazodonenefazodone results in increased expression of SGPP1 mRNA24136188
C022838nickel chloridenickel chloride affects the expression of SGPP1 mRNA22546817
D009538NicotineNicotine results in decreased expression of SGPP1 mRNA17997037
C012655nimesulidenimesulide results in increased expression of SGPP1 mRNA24136188
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SGPP1 mRNA26272509
D010634PhenobarbitalPhenobarbital affects the expression of SGPP1 mRNA23091169
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SGPP1 mRNA19073995
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SGPP1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SGPP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SGPP1 mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SGPP1 mRNA21215274
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SGPP1 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of SGPP1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SGPP1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid affects the expression of SGPP1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SGPP1 gene25560391
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of SGPP1 mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042392sphingosine-1-phosphate phosphatase activity-TAS-  
GO:0070780dihydrosphingosine-1-phosphate phosphatase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006668sphinganine-1-phosphate metabolic process-IEA-  
GO:0006670sphingosine metabolic process-IEA-  
GO:0016311dephosphorylation-IEA-  
GO:0030148sphingolipid biosynthetic process-TAS-  
GO:0097191extrinsic apoptotic signaling pathway-IEA-  
GO:0097193intrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00600Sphingolipid metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660661Sphingolipid de novo biosynthesisTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26485657Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). (2015)Barnawi JPLoS One