Gene: TDRD3

81550
-
tudor domain containing 3
protein-coding
13q21.2
Ensembl:ENSG00000083544 MIM:614392 Vega:OTTHUMG00000017007 UniprotKB:Q9H7E2
NC_000013.11
SNP Mapped
4   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.744e-3 (AD)  1.126e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12865240chr13:60545223 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9538740chr13:60535829 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9538710chr13:60461664 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4886227chr13:60416372 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NASP0.819
NSUN60.818
CDC160.815
SDCCAG80.803
FBXO70.799
INPP10.795
RRNAD10.793
TARSL20.791
THOC10.787
PCBP40.787

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.649
OR4F29-0.629
FER1L6-0.303
FCER2-0.277
IBSP-0.268
SPRR4-0.242
KRTAP17-1-0.24
ERVV-2-0.235
BMP15-0.232
DPPA4-0.232

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TDRD3 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TDRD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TDRD3 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of TDRD3 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TDRD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TDRD3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TDRD3 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TDRD3 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of TDRD3 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TDRD3 mRNA24449571
C015001arsenitearsenite results in increased methylation of TDRD3 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of TDRD3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TDRD3 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TDRD3 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TDRD3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TDRD3 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of TDRD3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TDRD3 mRNA26079696
C031180chrysenechrysene results in increased expression of TDRD3 mRNA26377693
D003471CuprizoneCuprizone results in decreased expression of TDRD3 mRNA27523638
D016572CyclosporineCyclosporine results in decreased methylation of TDRD3 promoter27989131
C014347decitabinedecitabine affects the expression of TDRD3 mRNA23300844
D002945CisplatinCisplatin affects the expression of TDRD3 mRNA23300844
C000944dicrotophosdicrotophos results in decreased expression of TDRD3 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TDRD3 mRNA22079256
D005047EtoposideTDRD3 protein affects the susceptibility to Etoposide16217747
D005557FormaldehydeFormaldehyde results in decreased expression of TDRD3 mRNA23649840
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TDRD3 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TDRD3 mRNA23086925|2479639
D008727MethotrexateMethotrexate results in increased expression of TDRD3 mRNA24449571
D016685MitomycinTDRD3 protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TDRD3 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TDRD3 mRNA25729387
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TDRD3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TDRD3 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TDRD3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TDRD3 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of TDRD3 mRNA23012394
D011794QuercetinQuercetin results in decreased expression of TDRD3 mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of TDRD3 mRNA21427059
D018038Sodium SeleniteSodium Selenite results in increased expression of TDRD3 mRNA18175754
C061133tamibarotenetamibarotene results in decreased expression of TDRD3 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TDRD3 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TDRD3 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TDRD3 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of TDRD3 mRNA15498508
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TDRD3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TDRD3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TDRD3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of TDRD3 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of TDRD3 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TDRD3 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TDRD3 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA21172665  
GO:0003713transcription coactivator activity-IDA21172665  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI26700805  
GO:0035064methylated histone binding-IDA21172665  
GO ID GO Term Qualifier Evidence PubMed
GO:0006325chromatin organization-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA21172665  
GO:0005654nucleoplasm-IDA-  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0035145exon-exon junction complexcolocalizes_withIDA20930030  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal