Gene: ZNF239

8187
HOK-2|MOK2
zinc finger protein 239
protein-coding
10q11.21
Ensembl:ENSG00000196793 MIM:601069 Vega:OTTHUMG00000018033 UniprotKB:Q16600
NC_000010.11
SNP Mapped
3   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.705e-1 (AD)  8.152e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2393938chr10:43568364 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs7894102chr10:43559519 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs10793442chr10:43556371 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C12orf40.832
SHROOM20.831
CYB561D10.828
BRI3BP0.823
KIAA15490.818
DTX40.815
RAD51D0.815
YARS20.813
FITM20.811
FBXO100.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC2A4-0.526
HEYL-0.471
ASB4-0.464
NID1-0.455
IL18RAP-0.45
MYL3-0.449
HEY2-0.442
PARD3B-0.441
OTOS-0.438
TEAD3-0.438

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of ZNF239 mRNA26690555
C015001arsenitearsenite results in increased methylation of ZNF239 promoter23974009
D001280AtrazineAtrazine results in decreased expression of ZNF239 mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of ZNF239 mRNA21179406
D002945CisplatinCisplatin results in increased expression of ZNF239 mRNA27392435
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ZNF239 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of ZNF239 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZNF239 mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ZNF239 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZNF239 mRNA28001369
D009151Mustard GasMustard Gas results in increased expression of ZNF239 mRNA15674844
C029938nickel sulfatenickel sulfate results in decreased expression of ZNF239 mRNA22714537
C014153pirimiphos methylpirimiphos methyl results in decreased expression of ZNF239 mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ZNF239 mRNA19710929
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ZNF239 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of ZNF239 mRNA22714537
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZNF239 mRNA25613284
D014212TretinoinTretinoin results in decreased expression of ZNF239 mRNA23724009
D014635Valproic AcidValproic Acid affects the expression of ZNF239 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ZNF239 mRNA24935251
D014638VanadatesVanadates results in increased expression of ZNF239 mRNA22714537
D014810Vitamin EVitamin E results in decreased expression of ZNF239 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IMP11278819  
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11278819  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP11278819  
GO:0003677DNA binding-TAS9121460  
GO:0003723RNA binding-TAS9121460  
GO:0005515protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA11278819  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006367transcription initiation from RNA polymerase II promoter-IBA21873635  
GO:0006369termination of RNA polymerase II transcription-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal