Gene: FAM107B

83641
C10orf45|HITS
family with sequence similarity 107 member B
protein-coding
10p13
Ensembl:ENSG00000065809 Vega:OTTHUMG00000017709 UniprotKB:Q9H098
NC_000010.11
SNP Mapped
CD|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.263e-2 (AD)  3.338e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17155611chr10:14625354 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)
rs11259210chr10:14591724 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1409390chr10:14585847 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERMN0.938
CLDND10.928
PIP4K2A0.911
FRMD4B0.91
ASPA0.909
TMCC30.909
RASSF20.903
RASGRP30.899
SLC44A10.897
EVI2A0.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.585
PCDH8-0.541
CDH22-0.536
CHRNA2-0.533
HCN4-0.518
KCNQ4-0.512
LTK-0.511
CNGB1-0.51
SDK1-0.506
KCNK3-0.498

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FAM107B mRNA"21354444|2269881
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FAM107B mRNA"19167446
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FAM107B mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FAM107B mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM107B mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of FAM107B mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM107B mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of FAM107B mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FAM107B mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM107B mRNA]21233418
D001151ArsenicArsenic affects the methylation of FAM107B gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of FAM107B mRNA24356939
C015001arsenitearsenite affects the expression of FAM107B mRNA22959463
D001280AtrazineAtrazine results in decreased expression of FAM107B mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of FAM107B mRNA24356939
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAM107B mRNA19770486|2156981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FAM107B mRNA"19150397|2001819
D004958EstradiolEstradiol affects the expression of FAM107B mRNA22574217
D004958EstradiolEstradiol results in decreased expression of FAM107B mRNA21185374
C006780bisphenol Abisphenol A affects the expression of FAM107B mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of FAM107B mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of FAM107B mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of FAM107B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FAM107B gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of FAM107B protein28903499
D002220CarbamazepineCarbamazepine affects the expression of FAM107B mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FAM107B mRNA17484886
D002706ChlordanChlordan results in decreased expression of FAM107B mRNA23153324
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of FAM107B mRNA25270620
D004390ChlorpyrifosChlorpyrifos results in increased expression of FAM107B mRNA21356183
D002994ClofibrateClofibrate results in increased expression of FAM107B mRNA25270620
C018021cobaltous chloridecobaltous chloride results in decreased expression of FAM107B mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of FAM107B mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FAM107B mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of FAM107B mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of FAM107B mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of FAM107B mRNA27523638
D003471CuprizoneCuprizone results in increased expression of FAM107B mRNA26577399
D003520CyclophosphamideCyclophosphamide metabolite results in decreased expression of FAM107B mRNA24356939
D003703DemecolcineDemecolcine results in increased expression of FAM107B mRNA23649840
D002945CisplatinCisplatin results in increased expression of FAM107B mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of FAM107B mRNA28302478
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of FAM107B mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of FAM107B mRNA19467301
D002117CalcitriolCalcitriol results in increased expression of FAM107B mRNA16002434
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of FAM107B mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of FAM107B mRNA21233418
D000431EthanolEthanol affects the expression of FAM107B mRNA26730594
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FAM107B mRNA17555576
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of FAM107B mRNA]15016801
D017313FenretinideFenretinide results in increased expression of FAM107B mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FAM107B mRNA21179406
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FAM107B mRNA25613284
C410337K 7174K 7174 results in increased expression of FAM107B mRNA24086573
D048628KetolidesKetolides analog results in increased expression of FAM107B mRNA24967691
C045463leflunomideleflunomide results in increased expression of FAM107B mRNA28988120
D001556LindaneLindane results in increased expression of FAM107B mRNA24356939
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FAM107B mRNA26011545
C523799MRK 003FAM107B results in decreased susceptibility to MRK 00319903844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of FAM107B mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FAM107B mRNA"25620056
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FAM107B mRNA25729387
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of FAM107B mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of FAM107B mRNA19270015|1948288
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FAM107B mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of FAM107B mRNA23811191
D011374ProgesteroneProgesterone results in increased expression of FAM107B mRNA23012394
C045950propiconazolepropiconazole results in increased expression of FAM107B mRNA21278054
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of FAM107B mRNA19167446
C059514resveratrolresveratrol results in decreased expression of FAM107B mRNA19167446
C059514resveratrolresveratrol results in increased expression of FAM107B mRNA23419489
D012834SilverSilver results in increased expression of FAM107B mRNA26014281
C017947sodium arsenitesodium arsenite results in decreased expression of FAM107B mRNA28595984
D012999SomanSoman results in increased expression of FAM107B mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of FAM107B mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of FAM107B mRNA17555576
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of FAM107B mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAM107B mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAM107B mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAM107B mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FAM107B mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of FAM107B mRNA22378314
D019284ThapsigarginThapsigargin results in decreased expression of FAM107B protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FAM107B mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FAM107B mRNA25729387
D014212TretinoinTretinoin results in increased expression of FAM107B mRNA20530235
D014212TretinoinTretinoin results in increased expression of FAM107B mRNA23830798
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM107B mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FAM107B mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of FAM107B mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FAM107B mRNA"26179874
D024483Vitamin K 3Vitamin K 3 affects the expression of FAM107B mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal