Gene info: ID 83648

Gene: FAM167A

GENE ID: 83648

Synonyms: C8orf13|D8S265

Description: family with sequence similarity 167 member A

Gene type: protein-coding

Location: 8p23.1

dbXrefs: Ensembl:ENSG00000154319 MIM:610085 Vega:OTTHUMG00000129361 UniprotKB:Q96KS9

RefSeq: NC_000008.11

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.988e-1 (AD) 4.281e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4310165	chr8:11437066 (GRCh38.p7)	C>A / C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC1A2	0.896
EZR	0.892
SLC4A4	0.887
FGFR3	0.887
ACSBG1	0.883
MLC1	0.882
NR2E1	0.879
BMP7	0.876
ARHGEF26	0.875
NTRK2	0.87

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CACNA1F	-0.407
NRG1	-0.406
TBC1D8B	-0.388
RSPO3	-0.385
AK7	-0.385
PAQR9	-0.385
FOXP2	-0.384
CHN2	-0.382
FGF10	-0.38
DEPDC1B	-0.377

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen results in increased expression of FAM167A mRNA	29067470
D020106	Acrylamide	Acrylamide results in increased expression of FAM167A mRNA	28959563
D001280	Atrazine	Atrazine results in increased expression of FAM167A mRNA	22378314
C006780	bisphenol A	bisphenol A results in decreased expression of FAM167A mRNA	27685785
C006780	bisphenol A	bisphenol A affects the expression of FAM167A mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of FAM167A mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of FAM167A mRNA	25596134
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of FAM167A mRNA	25596134
D002737	Chloroprene	Chloroprene results in increased expression of FAM167A mRNA	23125180
D003300	Copper	Copper deficiency results in increased expression of FAM167A mRNA	26033743
D016572	Cyclosporine	Cyclosporine affects the expression of FAM167A mRNA	25596134
D016572	Cyclosporine	Cyclosporine results in increased expression of FAM167A mRNA	20106945\|2798913
C014347	decitabine	decitabine affects the expression of FAM167A mRNA	23300844
D003907	Dexamethasone	Dexamethasone results in decreased expression of FAM167A mRNA	22733784
D003976	Diazinon	Diazinon results in increased methylation of FAM167A gene	22964155
D002945	Cisplatin	Cisplatin affects the expression of FAM167A mRNA	23300844
D002945	Cisplatin	Cisplatin results in decreased expression of FAM167A mRNA	25596134
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of FAM167A mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of FAM167A mRNA	28085963
D005411	Flame Retardants	Flame Retardants results in increased expression of FAM167A mRNA	27219277
D055768	Halogenated Diphenyl Ethers	Halogenated Diphenyl Ethers results in increased expression of FAM167A mRNA	27219277
D009532	Nickel	Nickel results in decreased expression of FAM167A mRNA	24768652
C028007	nickel monoxide	nickel monoxide results in increased expression of FAM167A mRNA	19167457
D010100	Oxygen	Oxygen deficiency affects the expression of FAM167A mRNA	25596134
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FAM167A mRNA	19710929
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of FAM167A mRNA	22714537
D011374	Progesterone	Progesterone results in increased expression of FAM167A mRNA	23018184
D011441	Propylthiouracil	Propylthiouracil results in increased expression of FAM167A mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of FAM167A mRNA	27029645
D012822	Silicon Dioxide	Silicon Dioxide analog affects the expression of FAM167A mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of FAM167A mRNA	25895662
D012906	Smoke	Smoke results in increased expression of FAM167A mRNA	21095227
D012999	Soman	Soman results in increased expression of FAM167A mRNA	19281266
D014635	Valproic Acid	Valproic Acid affects the expression of FAM167A mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of FAM167A mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of FAM167A gene	25560391
C088658	zoledronic acid	zoledronic acid results in decreased expression of FAM167A mRNA	25596134

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	25416956

GO ID	GO Term	Qualifier	Evidence	PubMed

GO ID	GO Term	Qualifier	Evidence	PubMed

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29207374	Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936. (2017 Dec 1)	Harris SE	Aging (Albany NY)