Gene: DTNBP1

84062
BLOC1S8|DBND|HPS7|My031|SDY
dystrobrevin binding protein 1
protein-coding
6p22.3
Ensembl:ENSG00000047579 MIM:607145 Vega:OTTHUMG00000014295 UniprotKB:Q96EV8
NG_009309.1
PubMed|SNP Mapped
1   ANCO-SNPs
OD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.061e-1 (AD)  6.862e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10456773chr6:15537094 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARK70.859
DPCD0.859
UFC10.859
COX7A20.858
MYL6B0.856
MRPS240.856
NDUFC10.852
NHP20.851
UQCR100.85
NDUFB20.847

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.704
OR4F29-0.668
RAET1E-0.295
VNN3-0.279
KCNJ15-0.276
P2RY14-0.269
CXCR2-0.261
CXCR1-0.258
PZP-0.246
FCGR3B-0.24

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DTNBP1 mRNA"19114083
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of DTNBP1 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DTNBP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DTNBP1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of DTNBP1 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DTNBP1 mRNA24449571
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of DTNBP1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DTNBP1 mRNA15034205|2222880
C006780bisphenol Abisphenol A affects the expression of DTNBP1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of DTNBP1 mRNA26079696
D002922CiguatoxinsCiguatoxins affects the expression of DTNBP1 mRNA18353800
D003024ClozapineDTNBP1 gene polymorphism results in increased susceptibility to Clozapine19369910
D003024ClozapineDTNBP1 protein affects the susceptibility to Clozapine19369910
D003300CopperDTNBP1 protein affects the susceptibility to Copper26199316
D003300CopperDTNBP1 protein affects the susceptibility to Copper26199316
D019327Copper SulfateCopper Sulfate results in decreased expression of DTNBP1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of DTNBP1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of DTNBP1 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DTNBP1 mRNA17361019|2126653
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DTNBP1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DTNBP1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DTNBP1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DTNBP1 mRNA17942748
D006220HaloperidolDTNBP1 gene polymorphism results in increased susceptibility to Haloperidol19369910
D006220HaloperidolDTNBP1 protein affects the susceptibility to Haloperidol19369910
C544151jinfukangjinfukang results in increased expression of DTNBP1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DTNBP1 mRNA23649840
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DTNBP1 mRNA25729387
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DTNBP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DTNBP1 mRNA22079256
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of DTNBP1 mRNA21427059
D013629TamoxifenTamoxifen affects the expression of DTNBP1 mRNA17555576
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DTNBP1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DTNBP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DTNBP1 mRNA15034205
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of DTNBP1 mRNA28973375
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DTNBP1 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DTNBP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DTNBP1 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of DTNBP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DTNBP1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased expression of DTNBP1 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15102850  19349376  20921223  22203680  23414517  25416956  
27107014  
GO ID GO Term Qualifier Evidence PubMed
GO:0001956positive regulation of neurotransmitter secretion-ISS-  
GO:0007596blood coagulation-IEA-  
GO:0008089anterograde axonal transport-ISS-  
GO:0010628positive regulation of gene expression-ISS-  
GO:0014059regulation of dopamine secretion-ISS-  
GO:0031175neuron projection development-IDA16980328  
GO:0031532actin cytoskeleton reorganization-ISS-  
GO:0032091negative regulation of protein binding-IEA-  
GO:0032438melanosome organization-NAS22203680  
GO:0043506regulation of JUN kinase activity-IEA-  
GO:0048490anterograde synaptic vesicle transport-ISS-  
GO:0048812neuron projection morphogenesis-ISS-  
GO:0048813dendrite morphogenesis-IEA-  
GO:0060155platelet dense granule organization-IEA-  
GO:0060159regulation of dopamine receptor signaling pathway-ISS-  
GO:0071901negative regulation of protein serine/threonine kinase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005789endoplasmic reticulum membrane-ISS-  
GO:0005829cytosol-TAS-  
GO:0010008endosome membrane-IEA-  
GO:0014069postsynaptic density-IDA16980328  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0016528sarcoplasm-IEA-  
GO:0030054cell junction-IEA-  
GO:0030424axon-ISS-  
GO:0030426growth cone-ISS-  
GO:0030496midbody-IDA-  
GO:0030672synaptic vesicle membrane-IDA16980328  
GO:0030672synaptic vesicle membrane-ISS-  
GO:0031083BLOC-1 complex-IDA15102850  22203680  
GO:0033162melanosome membrane-IEA-  
GO:0042383sarcolemma-ISS-  
GO:0043005neuron projection-IDA16980328  
GO:0043197dendritic spine-ISS-  
GO:0045211postsynaptic membrane-IEA-  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432722Golgi Associated Vesicle BiogenesisTAS
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20615259A polymorphism in the dysbindin gene (DTNBP1) associated with multiple psychiatric disorders including schizophrenia. (2010 Jul 9)Voisey JBehav Brain Funct
25697573Dysbindin (DTNBP1) variants are associated with hallucinations in schizophrenia. (2015 Jun)Cheah SYEur Psychiatry