Gene: C3orf20

84077
-
chromosome 3 open reading frame 20
protein-coding
3p25.1
Ensembl:ENSG00000131379 Vega:OTTHUMG00000155545 UniprotKB:Q8ND61
NC_000003.12
SNP Mapped
1   ANCO-SNPs
OD
0   
2.483e-1 (AD)  9.506e-1 (ND)   (Frontal_Cortex)
7.429e-2 (AD)  6.426e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12496846chr3:14731760 (GRCh38.p7)A>Gopioid dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13286620chr3:14715425C3orf20Promoter3.772e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR3A10.646
TAS2R300.617
OR56A40.613
PRSS480.61
OR2M70.606
CD1B0.606
TAS2R410.601
TMEM2470.599
ERVW-10.598
KCNQ1OT10.598

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G5-0.302
TMEM253-0.25
ROPN1B-0.244
LCN1-0.228
PXMP2-0.225
RAB41-0.224
ERICH2-0.221
CLEC11A-0.221
OR4F16-0.221
C16orf74-0.219

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in increased expression of C3ORF20 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of C3ORF20 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of C3ORF20 mRNA25181051
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of C3ORF20 mRNA27392435
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of C3ORF20 protein18951874
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of C3ORF20 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of C3ORF20 mRNA27392435
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of C3ORF20 protein18951874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal