Gene: C2orf88

84281
smAKAP
chromosome 2 open reading frame 88
protein-coding
2q32.2
Ensembl:ENSG00000187699 MIM:615117 Vega:OTTHUMG00000154361 UniprotKB:Q9BSF0
NC_000002.12
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.881e-1 (AD)  2.234e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs62184317chr2:189917038 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7563391chr2:189915077 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs62184315chr2:189907219 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFA0.829
ST180.825
SHC40.823
FRMD4B0.815
SLC44A10.815
FAM107B0.815
C21orf910.809
CLDND10.805
COL4A50.802
ANLN0.801

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.413
PRTN3-0.405
LTK-0.402
TCERG1L-0.393
GPR153-0.39
ASGR2-0.389
SCRT2-0.364
BEAN1-0.364
MGAT5B-0.357
ASB2-0.35

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C2ORF88 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C2ORF88 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of C2ORF88 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of C2ORF88 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of C2ORF88 mRNA24449571
D001151ArsenicArsenic affects the methylation of C2ORF88 gene25304211
D001554BenzeneBenzene results in decreased expression of C2ORF88 mRNA19162166
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of C2ORF88 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of C2ORF88 mRNA27685785
D019327Copper SulfateCopper Sulfate results in decreased expression of C2ORF88 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of C2ORF88 mRNA20106945
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of C2ORF88 mRNA27392435
D002945CisplatinCisplatin results in increased expression of C2ORF88 mRNA27392435
C118739entinostatentinostat results in increased expression of C2ORF88 mRNA27188386
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of C2ORF88 mRNA27392435
D009532NickelNickel results in decreased expression of C2ORF88 mRNA24768652|2558310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of C2ORF88 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of C2ORF88 mRNA26272509
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of C2ORF88 mRNA25895662
D018038Sodium SeleniteSodium Selenite results in decreased expression of C2ORF88 mRNA18175754
D014520UrethaneUrethane results in decreased expression of C2ORF88 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of C2ORF88 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  25416956  
GO:0034237protein kinase A regulatory subunit binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal