Gene: TPST2

8459
TANGO13B|TPST-2
tyrosylprotein sulfotransferase 2
protein-coding
22q12.1
Ensembl:ENSG00000128294 MIM:603126 Vega:OTTHUMG00000150987 UniprotKB:O60704
NC_000022.11
SNP Mapped
5   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.051e-1 (AD)  2.440e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4822743chr22:26585075 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs763090chr22:26574051 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs2283839chr22:26573096 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2283825chr22:26528569 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2283822chr22:26528346 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09856467chr22:26938937TPST29.730e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSPA40.823
DNAJA10.814
CCT50.808
DNAJB60.808
FKBP40.807
RCC20.807
STIP10.805
HSPA80.803
JDP20.802
PPID0.8

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.57
OR4F29-0.555
CTNNA3-0.339
SOX3-0.338
POU2AF1-0.336
C5orf64-0.33
PDE11A-0.329
TNFRSF13B-0.326
ZFP57-0.293
SLCO1A2-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TPST2 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TPST2 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TPST2 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPST2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPST2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TPST2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of TPST2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TPST2 mRNA27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TPST2 mRNA21298039
C044887beta-methylcholinebeta-methylcholine affects the expression of TPST2 mRNA21179406
C006780bisphenol Abisphenol A results in increased methylation of TPST2 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of TPST2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TPST2 mRNA15336504
D016572CyclosporineCyclosporine results in decreased expression of TPST2 mRNA25562108
D004041Dietary FatsDietary Fats results in decreased expression of TPST2 mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TPST2 mRNA17917374
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TPST2 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TPST2 mRNA17942748
D005472FluorouracilTPST2 protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in decreased expression of TPST2 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of TPST2 mRNA19167457
D005897GlafenineGlafenine results in decreased expression of TPST2 mRNA24136188
C492448ICG 001ICG 001 results in increased expression of TPST2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPST2 mRNA25613284
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TPST2 mRNA17917374
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of TPST2 gene21212295
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TPST2 mRNA23179753
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of TPST2 mRNA22401849
C028007nickel monoxidenickel monoxide results in decreased expression of TPST2 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of TPST2 mRNA24136188
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of TPST2 mRNA18593933
D010634PhenobarbitalPhenobarbital results in increased expression of TPST2 mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of TPST2 mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TPST2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TPST2 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of TPST2 mRNA21632981
D012969Sodium FluorideSodium Fluoride results in decreased expression of TPST2 protein28918527
D013629TamoxifenTamoxifen affects the expression of TPST2 mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TPST2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TPST2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of TPST2 gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TPST2 mRNA17949056
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TPST2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of TPST2 gene21212295
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TPST2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TPST2 mRNA28111298
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPST2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TPST2 mRNA26272509
D014520UrethaneUrethane results in increased expression of TPST2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of TPST2 mRNA23179753|2352703
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TPST2 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of TPST2 mRNA18593933
C088658zoledronic acidzoledronic acid results in decreased expression of TPST2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008146sulfotransferase activity-IBA21873635  
GO:0008476protein-tyrosine sulfotransferase activity-IBA21873635  
GO:0008476protein-tyrosine sulfotransferase activity-IDA9733778  23481380  
GO:0008476protein-tyrosine sulfotransferase activity-TAS-  
GO:0042803protein homodimerization activity-IPI23481380  
GO ID GO Term Qualifier Evidence PubMed
GO:0006478peptidyl-tyrosine sulfation-IBA21873635  
GO:0006478peptidyl-tyrosine sulfation-IDA9733778  23481380  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156584Cytosolic sulfonation of small moleculesTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal