Gene: NTNG2

84628
LHLL9381|Lmnt2|NTNG1|bA479K20.1
netrin G2
protein-coding
9q34.13
Ensembl:ENSG00000196358 Vega:OTTHUMG00000020835 UniprotKB:Q96CW9
NC_000009.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.142e-2 (AD)  1.229e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2274853chr9:132238978 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FEZF20.781
EFHD20.747
APC20.73
CDH240.71
TMEM184B0.685
NXPH30.683
HS3ST40.683
FBRSL10.68
TBKBP10.675
ITPK10.675

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.528
OR4F29-0.495
EBF2-0.411
MYF6-0.367
ISL1-0.359
C6orf141-0.353
MYO3A-0.352
TNFRSF8-0.347
LHX8-0.346
PTGFR-0.34

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTNG2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTNG2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NTNG2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NTNG2 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NTNG2 mRNA24449571
D001280AtrazineAtrazine results in increased expression of NTNG2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NTNG2 promoter]19654925
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NTNG2 promoter23359474
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of NTNG2 gene28505145
C026690cerous chloridecerous chloride results in increased expression of NTNG2 mRNA23573234
D003024ClozapineClozapine results in increased expression of NTNG2 mRNA17507910
D019327Copper SulfateCopper Sulfate results in increased expression of NTNG2 mRNA19549813
D003976DiazinonDiazinon results in increased methylation of NTNG2 gene22964155
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NTNG2 promoter23359474
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NTNG2 promoter23359474
D002117CalcitriolCalcitriol results in increased expression of NTNG2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of NTNG2 mRNA21592394
D004397FonofosFonofos results in decreased methylation of NTNG2 promoter22847954
C039281furanfuran results in increased methylation of NTNG2 gene22079235
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of NTNG2 gene28505145
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NTNG2 mRNA25890327
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NTNG2 mRNA28001369
C523799MRK 003MRK 003 results in decreased expression of NTNG2 mRNA21169257
D010278ParathionParathion results in decreased methylation of NTNG2 promoter22847954
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NTNG2 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of NTNG2 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of NTNG2 mRNA27862939
C012568terbufosterbufos results in decreased methylation of NTNG2 promoter22847954
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of NTNG2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of NTNG2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NTNG2 promoter]19654925
D014212TretinoinTretinoin results in increased expression of NTNG2 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of NTNG2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTNG2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NTNG2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NTNG2 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI21946559  
GO ID GO Term Qualifier Evidence PubMed
GO:0007409axonogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0030424axon-IEA-  
GO:0045171intercellular bridge-IDA-  
GO:0046658anchored component of plasma membrane-ISS-  
GO:0090543Flemming body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal