Gene: ZNRF1

84937
NIN283
zinc and ring finger 1
protein-coding
16q23.1
Ensembl:ENSG00000186187 MIM:612060 Vega:OTTHUMG00000137606 UniprotKB:Q8ND25
NC_000016.10
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.734e-1 (AD)  7.728e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs62059203chr16:75098967 (GRCh38.p7)G>Ccocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03485667chr16:75143200ZNRF15.000e-19Smoking27651444
cg02538248chr16:75045643ZNRF19.200e-8Smoking27651444
cg03485667chr16:75143200ZNRF11.510e-9Alcohol consumption der day27843151
cg03485667chr16:75143200ZNRF14.340e-12Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TOLLIP0.946
ATP6V0D10.946
ACOT70.946
PGBD50.941
SYNGR10.941
DNAJC50.94
FARSA0.937
GFOD20.935
FAM131A0.935
VPS26B0.933

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.57
OR4F29-0.514
REST-0.481
YES1-0.472
ASB4-0.471
PARD3B-0.468
IL18RAP-0.465
RAI14-0.458
MBNL3-0.454
MYL3-0.454

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of ZNRF1 mRNA"19095052
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ZNRF1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ZNRF1 mRNA"21346803
D020106AcrylamideAcrylamide results in increased expression of ZNRF1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ZNRF1 mRNA21641981
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ZNRF1 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZNRF1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZNRF1 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZNRF1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ZNRF1 mRNA20170705
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZNRF1 mRNA28628672
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNRF1 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ZNRF1 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ZNRF1 mRNA17484886
D004390ChlorpyrifosChlorpyrifos results in increased expression of ZNRF1 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZNRF1 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of ZNRF1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of ZNRF1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of ZNRF1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ZNRF1 mRNA25562108
D013759DronabinolDronabinol results in increased expression of ZNRF1 mRNA12237329
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZNRF1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZNRF1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNRF1 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of ZNRF1 mRNA22733784
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ZNRF1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZNRF1 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of ZNRF1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZNRF1 mRNA20938992
C546771gardiquimodgardiquimod results in decreased expression of ZNRF1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ZNRF1 mRNA]28003376
D005839GentamicinsGentamicins results in increased expression of ZNRF1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of ZNRF1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZNRF1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZNRF1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNRF1 mRNA28628672
C051890irinotecanirinotecan analog results in decreased expression of ZNRF1 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ZNRF1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ZNRF1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNRF1 mRNA28628672
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ZNRF1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ZNRF1 mRNA26378955
D008627Mercuric ChlorideMercuric Chloride affects the expression of ZNRF1 mRNA20353558
D008694MethamphetamineMethamphetamine results in increased expression of ZNRF1 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZNRF1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZNRF1 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in decreased expression of ZNRF1 mRNA29191790
D009538NicotineNicotine results in decreased expression of ZNRF1 mRNA17997037
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of ZNRF1 mRNA19095052
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ZNRF1 mRNA]28003376
D012715Sesame OilSesame Oil results in increased expression of ZNRF1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in increased expression of ZNRF1 mRNA23221170
C009277sodium arsenatesodium arsenate results in decreased expression of ZNRF1 mRNA23922661
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ZNRF1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ZNRF1 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZNRF1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZNRF1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZNRF1 mRNA26290441
C066340tolcaponetolcapone results in increased expression of ZNRF1 mRNA24136188
D014212TretinoinTretinoin results in increased expression of ZNRF1 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of ZNRF1 mRNA16604517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZNRF1 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ZNRF1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of ZNRF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ZNRF1 gene29154799
D024483Vitamin K 3Vitamin K 3 affects the expression of ZNRF1 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of ZNRF1 mRNA27188386
C070417Win 55212-2Win 55212-2 results in increased expression of ZNRF1 mRNA12237329

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-ISS-  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI19549727  19690564  27173435  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IDA22797923  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-TAS-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-ISS-  
GO:0070936protein K48-linked ubiquitination-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IEA-  
GO:0005768endosome-IDA-  
GO:0005829cytosol-IDA22797923  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IDA22797923  
GO:0030054cell junction-IEA-  
GO:0030672synaptic vesicle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal