Gene: MICALCL

84953
Ebitein1
MICAL C-terminal like
protein-coding
11p15.3
Ensembl:ENSG00000133816 MIM:612355 Vega:OTTHUMG00000165777 UniprotKB:Q6ZW33
NC_000011.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.115e-1 (AD)  1.089e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4757381chr11:12347098 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10831798chr11:12346259 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITK0.749
IL200.728
CHRNB40.719
DMBX10.71
ADM20.707
PLEKHS10.7
C2CD4A0.697
CLEC5A0.675
SPOCD10.671
LRRC150.654

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXL22-0.271
SNX22-0.262
TPPP2-0.251
NEU4-0.248
HMGN5-0.243
LRTOMT-0.238
CABLES1-0.237
DIAPH3-0.237
PTRHD1-0.237
LDHD-0.233

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MICALCL mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MICALCL mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICALCL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICALCL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICALCL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICALCL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICALCL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICALCL mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MICALCL mRNA16483693
C487081belinostatbelinostat results in increased expression of MICALCL mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICALCL mRNA"27188386
C006780bisphenol Abisphenol A results in decreased expression of MICALCL mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MICALCL mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MICALCL mRNA20938992
D003907Dexamethasone[Dexamethasone co-treated with Genistein] results in increased expression of MICALCL mRNA25136773
C118739entinostatentinostat results in increased expression of MICALCL mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICALCL mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MICALCL mRNA20938992
C039281furanfuran results in increased expression of MICALCL mRNA27387713
D019833Genistein[Dexamethasone co-treated with Genistein] results in increased expression of MICALCL mRNA25136773
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MICALCL mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MICALCL mRNA24796395
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MICALCL mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MICALCL mRNA"25554681
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of MICALCL mRNA17616710
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICALCL mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of MICALCL mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MICALCL mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of MICALCL mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of MICALCL mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MICALCL mRNA23806026
D018038Sodium SeleniteSodium Selenite results in decreased expression of MICALCL mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MICALCL mRNA26377647|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MICALCL mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MICALCL mRNA25613284
D014212TretinoinTretinoin results in decreased expression of MICALCL mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MICALCL gene27618143
C012589trichostatin Atrichostatin A affects the expression of MICALCL mRNA28542535
D014635Valproic AcidValproic Acid results in increased expression of MICALCL mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0051019mitogen-activated protein kinase binding-IBA21873635  
GO:0051019mitogen-activated protein kinase binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0008150biological_process-ND-  
GO:0030154cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal