Gene: RERG

85004
-
RAS like estrogen regulated growth inhibitor
protein-coding
12p12.3
Ensembl:ENSG00000134533 MIM:612664 Vega:OTTHUMG00000168745 UniprotKB:Q96A58
NC_000012.12
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.814e-1 (AD)  4.973e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs767201chr12:15217944 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7955309chr12:15215264 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RANBP3L0.86
GPAM0.838
STOX10.835
GRAMD1C0.834
GJB60.834
AMOT0.831
MSI20.827
EGFR0.823
TMEM470.822
MID10.819

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADTRP-0.394
C9orf3-0.384
RHO-0.376
DUSP27-0.375
GALNT14-0.375
CREB3L1-0.374
TRABD2A-0.371
NRG1-0.37
TMEFF2-0.369
DPP4-0.368

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of RERG mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RERG mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RERG mRNA"19167446
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RERG mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RERG mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RERG mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of RERG mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RERG gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of RERG mRNA26705709
D001280AtrazineAtrazine results in decreased expression of RERG mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RERG mRNA22228805
D004958EstradiolEstradiol results in increased expression of RERG mRNA19167446|2118537
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of RERG mRNA]21185374
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of RERG mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of RERG mRNA25912373
C006780bisphenol Abisphenol A affects the expression of RERG mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of RERG mRNA26496021
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RERG mRNA20938992
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RERG mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with ESR1 protein] results in increased expression of RERG mRNA18310284
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of RERG mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of RERG mRNA19167446
D003375CoumestrolESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of RERG mRNA]18310284
D003471CuprizoneCuprizone affects the expression of RERG mRNA26577399
D003561CytarabineCytarabine results in decreased expression of RERG mRNA21198554
C014347decitabine[decitabine co-treated with TFAP2C protein] results in increased expression of RERG mRNA19458056
C014347decitabineTFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of RERG mRNA]19458056
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of RERG mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of RERG mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RERG mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RERG mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RERG mRNA27392435
D002945CisplatinCisplatin results in increased expression of RERG mRNA27392435
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RERG mRNA"19480007
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RERG mRNA20938992
D004397FonofosFonofos results in increased methylation of RERG promoter22847954
C070081fulvestrantRERG affects the susceptibility to fulvestrant24169358
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of RERG mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of RERG mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RERG mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RERG mRNA26752646
C018091maduramicinmaduramicin results in decreased expression of RERG mRNA29128925
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RERG mRNA20938992
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to RERG promoter]20348232
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of RERG mRNA20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RERG mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride affects the expression of RERG mRNA20864626
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RERG mRNA"20188158
D009532NickelNickel results in decreased expression of RERG mRNA24768652|2558310
D010278ParathionParathion results in increased methylation of RERG promoter22847954
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of RERG mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of RERG mRNA19482888
D011441PropylthiouracilPropylthiouracil results in decreased expression of RERG mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of RERG mRNA]21185374
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of RERG mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RERG mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of RERG mRNA21795629
D013629TamoxifenTamoxifen results in increased expression of RERG mRNA25123088
C012568terbufosterbufos results in increased methylation of RERG promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RERG gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to RERG gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RERG mRNA19574409
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of RERG mRNA28065790
D014212TretinoinTretinoin results in decreased expression of RERG mRNA23724009
D014212TretinoinTretinoin results in increased expression of RERG mRNA21934132
C012589trichostatin ATFAP2C protein promotes the reaction [[decitabine co-treated with trichostatin A] results in increased expression of RERG mRNA]19458056
C012589trichostatin A[trichostatin A co-treated with TFAP2C protein] results in increased expression of RERG mRNA19458056
C012589trichostatin Atrichostatin A results in increased expression of RERG mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RERG mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RERG mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RERG mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RERG mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RERG mRNA23179753|2438349
C088658zoledronic acidzoledronic acid results in decreased expression of RERG mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IDA11533059  
GO:0005525GTP binding-IEA-  
GO:0019003GDP binding-TAS11533059  
GO:0030331estrogen receptor binding-NAS11533059  
GO ID GO Term Qualifier Evidence PubMed
GO:0007264small GTPase mediated signal transduction-NAS11533059  
GO:0008285negative regulation of cell proliferation-IDA11533059  
GO:0009725response to hormone-IDA11533059  
GO:0030308negative regulation of cell growth-IDA11533059  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11533059  
GO:0005829cytosol-IDA11533059  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27453436Methylation of a panel of genes in peripheral blood leukocytes is associated with colorectal cancer. (2016 Jul 25)Luo XSci Rep