Gene: MYOM1

8736
SKELEMIN
myomesin 1
protein-coding
18p11.31
Ensembl:ENSG00000101605 MIM:603508 Vega:OTTHUMG00000178209 UniprotKB:P52179
NG_032120.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.072e-1 (AD)  7.441e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10153321chr18:3176379 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02935272chr18:3067385MYOM13.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DOCK10.808
ZCCHC240.781
KAT2B0.768
COPZ20.763
ASB40.761
PARD3B0.756
RMDN10.756
S100B0.744
YES10.743
ADD30.742

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OSBPL10-0.596
MKX-0.588
ANKRD34C-0.585
PRSS16-0.577
GABRG3-0.574
FHL2-0.572
MUM1L1-0.57
MCHR1-0.566
XKR7-0.564
TPBG-0.564

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MYOM1 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of MYOM1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MYOM1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MYOM1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MYOM1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MYOM1 mRNA16483693
D003913DextroamphetamineDextroamphetamine affects the expression of MYOM1 mRNA12205029
D003913DextroamphetamineSOD1 affects the reaction [Dextroamphetamine affects the expression of MYOM1 mRNA]12205029
C006632arsenic trioxidearsenic trioxide results in decreased expression of MYOM1 protein15894607
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of MYOM1 protein15894607
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MYOM1 mRNA21715664|2222880
D004958EstradiolEstradiol results in decreased expression of MYOM1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of MYOM1 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MYOM1 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MYOM1 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of MYOM1 mRNA22300585
D003042CocaineCocaine affects the expression of MYOM1 mRNA20187946
D016572CyclosporineCyclosporine results in increased expression of MYOM1 mRNA27989131
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MYOM1 mRNA"22485181
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MYOM1 mRNA20938992
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MYOM1 mRNA17183730
D008345ManganeseManganese results in increased expression of MYOM1 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of MYOM1 mRNA17175027
D008694MethamphetamineMethamphetamine results in increased expression of MYOM1 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MYOM1 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MYOM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MYOM1 mRNA"25554681
D009532NickelNickel results in decreased expression of MYOM1 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYOM1 mRNA27935865
D010100OxygenOxygen deficiency results in increased expression of MYOM1 mRNA26516004
D010126OzoneOzone results in increased expression of MYOM1 mRNA17095637
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYOM1 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MYOM1 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of MYOM1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of MYOM1 mRNA18301758|2081375
C009277sodium arsenatesodium arsenate affects the expression of MYOM1 mRNA26427749
D018038Sodium SeleniteSodium Selenite results in decreased expression of MYOM1 mRNA18175754
D053260SootSoot results in increased expression of MYOM1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYOM1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of MYOM1 mRNA25975270
D013792ThalidomideThalidomide results in decreased expression of MYOM1 mRNA26006729|2621778
C009495titanium dioxidetitanium dioxide results in decreased expression of MYOM1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MYOM1 mRNA20133372
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of MYOM1 protein15894607
D014212TretinoinTretinoin results in decreased expression of MYOM1 protein15894607
D014241TrichloroethyleneTrichloroethylene results in increased expression of MYOM1 mRNA25549359
D014520UrethaneUrethane results in decreased expression of MYOM1 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MYOM1 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of MYOM1 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23414517  
GO:0008307structural constituent of muscle-IBA21873635  
GO:0008307structural constituent of muscle-TAS7505783  
GO:0019900kinase binding-IPI12972258  
GO:0042802identical protein binding-IPI18059477  
GO:0042803protein homodimerization activity-ISS-  
GO:0051015actin filament binding-IBA21873635  
GO:0051371muscle alpha-actinin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002074extraocular skeletal muscle development-IEA-  
GO:0006941striated muscle contraction-IBA21873635  
GO:0007015actin filament organization-IBA21873635  
GO:0010628positive regulation of gene expression-IGI25152160  
GO:0010628positive regulation of gene expression-IMP25152160  
GO:0010737protein kinase A signaling-IMP25152160  
GO:0030240skeletal muscle thin filament assembly-IBA21873635  
GO:0030241skeletal muscle myosin thick filament assembly-IBA21873635  
GO:0045214sarcomere organization-IBA21873635  
GO:0048739cardiac muscle fiber development-IBA21873635  
GO:0050714positive regulation of protein secretion-IGI25152160  
GO:0050714positive regulation of protein secretion-IMP25152160  
GO:0055003cardiac myofibril assembly-IBA21873635  
GO:0055008cardiac muscle tissue morphogenesis-IBA21873635  
GO:0071688striated muscle myosin thick filament assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005859muscle myosin complex-IBA21873635  
GO:0005863striated muscle myosin thick filament-TAS6537951  
GO:0005865striated muscle thin filament-IBA21873635  
GO:0030018Z disc-IBA21873635  
GO:0031430M band-IBA21873635  
GO:0031430M band-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal