Gene: CRADD

8738
MRT34|RAIDD
CASP2 and RIPK1 domain containing adaptor with death domain
protein-coding
12q22
Ensembl:ENSG00000169372 MIM:603454 Vega:OTTHUMG00000170322 UniprotKB:P78560
NG_032159.2
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.850e-1 (AD)  2.792e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9668896chr12:93677236 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MMAB0.774
GRHPR0.761
LSM30.754
ATOX10.753
SMIM70.753
MRPS280.749
SEC11C0.748
MRPS330.745
FUNDC20.744
SCCPDH0.741

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.493
OR4F29-0.48
MTRNR2L6-0.362
MTRNR2L9-0.347
RNF223-0.307
TTLL10-0.3
MTRNR2L10-0.298
P2RY14-0.285
SIX1-0.281
PTGDR2-0.273

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CRADD mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of CRADD mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CRADD mRNA17562736
D000111AcetylcysteineAcetylcysteine results in decreased expression of CRADD mRNA16084531
D020106AcrylamideAcrylamide results in increased expression of CRADD mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CRADD mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CRADD gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CRADD mRNA28070108
D001554BenzeneBenzene results in increased expression of CRADD mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CRADD mRNA20064835|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CRADD mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CRADD mRNA"26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CRADD mRNA"17944540
D019207beta Carotenebeta Carotene results in increased expression of CRADD mRNA17034753
C006780bisphenol Abisphenol A affects the expression of CRADD mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CRADD protein21277958
C006780bisphenol Abisphenol A results in decreased expression of CRADD mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CRADD mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CRADD mRNA22079614
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CRADD mRNA16934159
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CRADD gene20938992
D002994ClofibrateClofibrate results in increased expression of CRADD mRNA16081524
D019327Copper SulfateCopper Sulfate results in decreased expression of CRADD mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CRADD mRNA20106945|2798913
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CRADD mRNA28628672
D002945CisplatinCisplatin results in decreased expression of CRADD mRNA22023808
D019422Dietary SucroseDietary Sucrose results in increased expression of CRADD mRNA26033743
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of CRADD mRNA16084531
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CRADD mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CRADD gene20938992
C039281furanfuran results in increased expression of CRADD mRNA20562052
D005665FurosemideFurosemide affects the expression of CRADD mRNA17497460
D006918HydroxyureaHydroxyurea results in increased mutagenesis of CRADD gene16868089
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CRADD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CRADD mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CRADD gene20938992
D008770MethylnitrosoureaMethylnitrosourea results in increased mutagenesis of CRADD gene16868089
C122062NSC 674495CRADD protein affects the susceptibility to NSC 67449517674193
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of CRADD mRNA"22937105
D010269ParaquatParaquat results in increased expression of CRADD mRNA18836921
D010424PentobarbitalPentobarbital results in increased expression of CRADD mRNA16978161
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CRADD mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CRADD mRNA22079256
D012402RotenoneRotenone results in decreased expression of CRADD mRNA19013527
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of CRADD mRNA"21148743
D012834SilverSilver results in decreased expression of CRADD mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of CRADD mRNA12016162
D013739TestosteroneTestosterone results in decreased expression of CRADD mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CRADD gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CRADD mRNA12167310|1597263
D014415TunicamycinTunicamycin results in decreased expression of CRADD mRNA17127020

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IBA21873635  
GO:0002020protease binding-IPI9044836  
GO:0005515protein binding-IPI8985253  11156409  15073321  16652156  17159900  22458338  
25416956  25910212  27107012  
GO:0030674protein binding, bridging-IPI9044836  
GO:0070513death domain binding-IPI9044836  
GO ID GO Term Qualifier Evidence PubMed
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IBA21873635  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-IBA21873635  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-IMP21726810  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-IC9044836  
GO:0042981regulation of apoptotic process-TAS-  
GO:0043065positive regulation of apoptotic process-IDA11821383  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IBA21873635  
GO:0071260cellular response to mechanical stimulus-IBA21873635  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO:2001235positive regulation of apoptotic signaling pathway-IBA21873635  
GO:2001235positive regulation of apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
GO:0032449CBM complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-6803207TP53 Regulates Transcription of Caspase Activators and CaspasesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal