Gene: INPP4B

8821
-
inositol polyphosphate-4-phosphatase type II B
protein-coding
4q31.21
Ensembl:ENSG00000109452 MIM:607494 Vega:OTTHUMG00000161341 UniprotKB:O15327
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.246e-1 (AD)  8.441e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9308148chr4:142177786 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04084236chr4:143766602INPP4BPromoter2.800e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPN40.856
ITPR10.854
CHM0.853
SLC4A100.849
SGTB0.849
B4GALT60.848
NCKAP10.848
PBX10.847
GABRB20.844
KCTD160.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.464
CSAG1-0.455
BEST3-0.438
GNG8-0.428
ROM1-0.425
TMEM102-0.424
RAB13-0.42
TIMP1-0.409
S100A16-0.399
SFN-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of INPP4B mRNA19041380
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of INPP4B mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of INPP4B mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of INPP4B gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of INPP4B mRNA16483693
D001104ArbutinArbutin results in increased expression of INPP4B mRNA17103032
D001151ArsenicArsenic affects the methylation of INPP4B gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of INPP4B mRNA"25351596
D001280AtrazineAtrazine results in increased expression of INPP4B mRNA22378314
D001554BenzeneBenzene results in decreased expression of INPP4B mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of INPP4B mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of INPP4B mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of INPP4B mRNA"20382639
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of INPP4B mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of INPP4B mRNA24758408
D004958EstradiolEstradiol results in increased expression of INPP4B mRNA21795739|2301914
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased expression of INPP4B mRNA]21795739
C006780bisphenol Abisphenol A results in increased expression of INPP4B mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of INPP4B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of INPP4B gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of INPP4B mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of INPP4B mRNA26191083
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of INPP4B mRNA20971185
D003375CoumestrolCoumestrol results in decreased expression of INPP4B mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of INPP4B mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of INPP4B mRNA20106945
D003630DaunorubicinINPP4B affects the susceptibility to Daunorubicin17545624
D003703DemecolcineDemecolcine results in increased expression of INPP4B mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of INPP4B mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of INPP4B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of INPP4B mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of INPP4B mRNA16002434|2648566
D005557FormaldehydeFormaldehyde results in increased expression of INPP4B mRNA27664576
C069837fullerene C60fullerene C60 results in decreased expression of INPP4B mRNA19167457
D019833GenisteinGenistein results in decreased expression of INPP4B mRNA15378649
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of INPP4B mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of INPP4B mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of INPP4B mRNA23086925
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of INPP4B mRNA"24972896
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of INPP4B mRNA"26251327
C008493methylselenic acidmethylselenic acid affects the expression of INPP4B mRNA14617803
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of INPP4B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of INPP4B mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of INPP4B mRNA20971185
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
D010269ParaquatParaquat results in increased expression of INPP4B mRNA18198484
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of INPP4B mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of INPP4B mRNA28511854
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of INPP4B mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of INPP4B mRNA22714537
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased expression of INPP4B mRNA]21795739
D011374ProgesteroneProgesterone results in decreased expression of INPP4B mRNA20864642
D011441PropylthiouracilPropylthiouracil affects the expression of INPP4B mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of INPP4B mRNA14699072
C059514resveratrolresveratrol results in decreased expression of INPP4B mRNA18586690|1916744
D015474IsotretinoinIsotretinoin results in decreased expression of INPP4B mRNA20436886
C078903seocalcitolseocalcitol results in increased expression of INPP4B mRNA12040012
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of INPP4B mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of INPP4B mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of INPP4B mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of INPP4B mRNA28065790
D014212TretinoinTretinoin results in increased expression of INPP4B mRNA23830798
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of INPP4B mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of INPP4B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of INPP4B gene29154799
D014635Valproic AcidValproic Acid results in increased expression of INPP4B mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of INPP4B mRNA22714537
D014750VincristineVincristine results in increased expression of INPP4B mRNA23649840
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of INPP4B mRNA"27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of INPP4B mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI24407287  
GO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity-IBA21873635  
GO:0016316phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity-TAS-  
GO:0017161inositol-1,3,4-trisphosphate 4-phosphatase activity-TAS-  
GO:0034597phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity-IEA-  
GO:0052828inositol-3,4-bisphosphate 4-phosphatase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006661phosphatidylinositol biosynthetic process-TAS-  
GO:0007165signal transduction-TAS9295334  
GO:0016311dephosphorylation-IEA-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0043647inositol phosphate metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-1660499Synthesis of PIPs at the plasma membraneTAS
R-HSA-1660516Synthesis of PIPs at the early endosome membraneTAS
R-HSA-1855183Synthesis of IP2, IP, and Ins in the cytosolTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal