Gene: KSR1

8844
KSR|RSU2
kinase suppressor of ras 1
protein-coding
17q11.2
Ensembl:ENSG00000141068 MIM:601132 Vega:OTTHUMG00000132051 UniprotKB:Q8IVT5
NC_000017.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.506e-1 (AD)  1.548e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17778162chr17:27523483 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04299274chr17:25798741KSR13.900e-18Smoking27651444
cg02512902chr17:25799447KSR13.300e-14Smoking27651444
cg05784862chr17:25799018KSR14.600e-10Smoking27651444
cg21615831chr17:25798202KSR16.000e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NSD10.899
MCM3AP0.891
SETD50.888
UBR40.886
ASXL10.88
MAN2A20.879
FAM160B20.877
C2CD30.874
PEAK10.873
EPG50.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.505
OR4F29-0.472
HCRT-0.297
OXT-0.291
HMX2-0.286
FOXB1-0.285
LHX5-0.284
IAPP-0.284
SIM1-0.284
NANOGNB-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KSR1 mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of KSR1 mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KSR1 mRNA"27188386
C496492abrineabrine results in increased expression of KSR1 mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of KSR1 mRNA29067470
D020106AcrylamideAcrylamide results in increased expression of KSR1 mRNA28959563
D001554BenzeneTRP53 protein inhibits the reaction [Benzene results in increased expression of KSR1]15935813
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KSR1 mRNA26001963
D004958EstradiolEstradiol results in increased expression of KSR1 mRNA23094148
C006780bisphenol Abisphenol A results in decreased expression of KSR1 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of KSR1 mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KSR1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of KSR1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of KSR1 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of KSR1 mRNA16002434
C574336excavatolide Bexcavatolide B results in decreased expression of KSR1 protein26790859
D005557FormaldehydeFormaldehyde results in increased expression of KSR1 mRNA23649840
C039281furanfuran results in decreased expression of KSR1 mRNA25539665
D017313FenretinideFenretinide results in increased expression of KSR1 mRNA28973697
C045463leflunomideleflunomide results in increased expression of KSR1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of KSR1 mRNA"24972896
D008727MethotrexateMethotrexate results in decreased expression of KSR1 mRNA24449571
D008731MethoxychlorMethoxychlor results in increased methylation of KSR1 gene23303685
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KSR1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KSR1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of KSR1 mRNA17426115
D011794QuercetinQuercetin results in increased expression of KSR1 mRNA27514524
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KSR1 mRNA25895662
D012834SilverSilver results in increased expression of KSR1 mRNA27131904
D012969Sodium FluorideSodium Fluoride results in decreased expression of KSR1 mRNA27862939
D012999SomanSoman results in decreased expression of KSR1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KSR1 promoter]19654925
D014118Toxins, Biological"Toxins, Biological affects the expression of KSR1 mRNA"19682533
C012589trichostatin Atrichostatin A results in increased expression of KSR1 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KSR1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of KSR1 mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of KSR1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of KSR1 gene29154799
D015032ZincZinc results in increased phosphorylation of KSR1 protein14685271

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-NAS8521512  
GO:0005078MAP-kinase scaffold activity-ISS-  
GO:0005515protein binding-IPI11909642  20679487  22752157  27086506  
GO:0005524ATP binding-IEA-  
GO:0008022protein C-terminus binding-IDA22572157  
GO:0031434mitogen-activated protein kinase kinase binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0051087chaperone binding-IEA-  
GO:0051879Hsp90 protein binding-IEA-  
GO:007188914-3-3 protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0007265Ras protein signal transduction-IBA21873635  
GO:0007265Ras protein signal transduction-ISS-  
GO:0007265Ras protein signal transduction-NAS8521512  
GO:0019933cAMP-mediated signaling-ISS-  
GO:0042127regulation of cell proliferation-ISS-  
GO:0043405regulation of MAP kinase activity-ISS-  
GO:0043410positive regulation of MAPK cascade-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA22572157  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
GO:0016020membrane-IDA22572157  
GO:0032587ruffle membrane-IEA-  
GO:0032991protein-containing complex-IDA22572157  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673000RAF activationTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5674135MAP2K and MAPK activationTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802948Signaling by high-kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23581412Terbinafine inhibits KSR1 and suppresses Raf-MEK-ERK signaling in oral squamous cell carcinoma cells. (2013)Li BNeoplasma