Gene: SYNJ2

8871
INPP5H
synaptojanin 2
protein-coding
6q25.3
Ensembl:ENSG00000078269 MIM:609410 Vega:OTTHUMG00000015904 UniprotKB:O15056
NG_029907.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.222e-1 (AD)  1.077e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1750034chr6:158059112 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs9365674chr6:157990124 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05987787chr6:158448508SYNJ21.600e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH3GL30.865
NIPAL30.859
CCP1100.853
PLCL10.851
SEMA4D0.847
SLC22A150.84
KLHL40.835
PDE1C0.835
MAP70.834
CNTN20.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF43-0.413
ADORA2B-0.396
GPR143-0.395
EYA1-0.386
OR4F29-0.385
HKDC1-0.379
EYA2-0.378
PON3-0.377
MCC-0.374
RGR-0.361

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SYNJ2 mRNA"22698814|2890350
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SYNJ2 mRNA28329830
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SYNJ2 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SYNJ2 mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SYNJ2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of SYNJ2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SYNJ2 mRNA25704631
D000082AcetaminophenAcetaminophen results in increased expression of SYNJ2 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of SYNJ2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SYNJ2 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYNJ2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SYNJ2 mRNA24449571
D001151ArsenicArsenic affects the expression of SYNJ2 mRNA18414638
C006632arsenic trioxidearsenic trioxide results in decreased expression of SYNJ2 mRNA12852829
C487081belinostatbelinostat results in decreased expression of SYNJ2 mRNA26272509
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SYNJ2 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of SYNJ2 mRNA23019147
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of SYNJ2 mRNA17404688
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SYNJ2 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SYNJ2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SYNJ2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of SYNJ2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SYNJ2 gene28505145
C032036bromobenzenebromobenzene results in decreased expression of SYNJ2 mRNA12628495
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SYNJ2 mRNA15336504
D002994ClofibrateClofibrate results in increased expression of SYNJ2 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of SYNJ2 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of SYNJ2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of SYNJ2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of SYNJ2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased methylation of SYNJ2 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of SYNJ2 mRNA27989131
D003907DexamethasoneDexamethasone results in decreased expression of SYNJ2 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SYNJ2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SYNJ2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SYNJ2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SYNJ2 mRNA17361019|2126653
D002945CisplatinSYNJ2 protein affects the susceptibility to Cisplatin16217747
C000944dicrotophosdicrotophos results in increased expression of SYNJ2 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of SYNJ2 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of SYNJ2 mRNA16002434
C118739entinostatentinostat results in increased expression of SYNJ2 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SYNJ2 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SYNJ2 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of SYNJ2 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SYNJ2 mRNA28329830
C039281furanfuran results in increased expression of SYNJ2 mRNA25539665
D019833GenisteinGenistein results in increased expression of SYNJ2 mRNA23019147
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SYNJ2 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SYNJ2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SYNJ2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SYNJ2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SYNJ2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SYNJ2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SYNJ2 mRNA28628672
C410337K 7174K 7174 results in increased expression of SYNJ2 mRNA24086573
C042720mercuric bromidemercuric bromide results in increased expression of SYNJ2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of SYNJ2 mRNA26307267
D008727MethotrexateMethotrexate results in increased expression of SYNJ2 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SYNJ2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SYNJ2 mRNA"25620056
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of SYNJ2 mRNA17616710
D009966OrphenadrineOrphenadrine affects the expression of SYNJ2 mRNA23665939
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SYNJ2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SYNJ2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SYNJ2 mRNA18301758|2381119
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SYNJ2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SYNJ2 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SYNJ2 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SYNJ2 mRNA19162173
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of SYNJ2 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of SYNJ2 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in decreased expression of SYNJ2 mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNJ2 mRNA19059307
D012643SeleniumSelenium results in increased expression of SYNJ2 mRNA19244175
D012834SilverSilver results in increased expression of SYNJ2 mRNA28959546
D012906SmokeSmoke results in increased expression of SYNJ2 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of SYNJ2 gene28589171
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of SYNJ2 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SYNJ2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SYNJ2 mRNA21632981
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SYNJ2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SYNJ2 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SYNJ2 mRNA20819909|2597527
D013853ThioacetamideThioacetamide results in increased expression of SYNJ2 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SYNJ2 mRNA28065790
D014212TretinoinTretinoin results in increased expression of SYNJ2 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of SYNJ2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNJ2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SYNJ2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of SYNJ2 mRNA23665938
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SYNJ2 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride affects the expression of SYNJ2 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of SYNJ2 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of SYNJ2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of SYNJ2 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of SYNJ2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IEA-  
GO:0004438phosphatidylinositol-3-phosphatase activity-TAS-  
GO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity-IBA21873635  
GO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity-TAS-  
GO:0004445inositol-polyphosphate 5-phosphatase activity-IBA21873635  
GO:0005515protein binding-IPI15090612  17474147  20936779  
GO:0017124SH3 domain binding-IBA21873635  
GO:0030165PDZ domain bindingNOTIBA21873635  
GO:0034596phosphatidylinositol phosphate 4-phosphatase activity-TAS-  
GO:0043812phosphatidylinositol-4-phosphate phosphatase activity-IBA21873635  
GO:0043813phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity-TAS-  
GO:0052629phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006661phosphatidylinositol biosynthetic process-TAS-  
GO:0007420brain development-IBA21873635  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0046855inositol phosphate dephosphorylation-IBA21873635  
GO:0046856phosphatidylinositol dephosphorylation-IBA21873635  
GO:0046856phosphatidylinositol dephosphorylation-IEA-  
GO:0061024membrane organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005881cytoplasmic microtubule-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0030424axon-IEA-  
GO:0031315extrinsic component of mitochondrial outer membrane-IBA21873635  
GO:0032587ruffle membrane-IBA21873635  
GO:0043679axon terminus-IBA21873635  
GO:0045121membrane raft-IEA-  
GO:0048471perinuclear region of cytoplasm-IBA21873635  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-1660499Synthesis of PIPs at the plasma membraneTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal