Gene: SLC28A1

9154
CNT1|HCNT1
solute carrier family 28 member 1
protein-coding
15q25.3
Ensembl:ENSG00000156222 MIM:606207 Vega:OTTHUMG00000148668 UniprotKB:O00337
NC_000015.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.129e-1 (AD)  8.398e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4980343chr15:84928050 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11634491chr15:84903829 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NGFR0.653
SNAI10.551
GDNF0.551
CLCF10.547
RELB0.545
SPSB10.542
TNFRSF12A0.535
NMB0.535
LMNA0.535
ITK0.527

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
METTL24-0.315
DBH-0.311
KLHL34-0.3
ERBB4-0.278
IGF1-0.276
NMBR-0.271
KIT-0.267
LYPD6-0.265
HAPLN1-0.265
PRLHR-0.261

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00441GemcitabineSmall Molecule95058-81-4ApprovedTransporter
DB00495ZidovudineSmall Molecule30516-87-1ApprovedTransporter
DB00649StavudineSmall Molecule3056-17-5Approved|InvestigationalTransporter
DB09327Tegafur-uracilSmall Molecule74578-38-4Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC28A1 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of SLC28A1 mRNA21420995|2906747
D000241AdenosineAdenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
D000241AdenosineSLC28A1 protein affects the transport of Adenosine9124315
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC28A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC28A1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC28A1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC28A1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of SLC28A1 mRNA22378314
D001374AzacitidineSLC28A1 protein results in increased susceptibility to Azacitidine19139132
D001374AzacitidineSLC28A1 protein results in increased uptake of Azacitidine19139132
D001374Azacitidine[SLC28A1 protein results in increased uptake of Azacitidine] which results in decreased expression of DNMT1 protein19139132
D001374AzacitidineSodium affects the reaction [SLC28A1 protein results in increased uptake of Azacitidine]19139132
C018475butyraldehydebutyraldehyde results in increased expression of SLC28A1 mRNA26079696
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SLC28A1 mRNA26033743
D003300CopperCopper deficiency results in increased expression of SLC28A1 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of SLC28A1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of SLC28A1 mRNA20106945
D003561CytarabineCytarabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]10772724
D003561CytarabineCytarabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D003562CytidineCytidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
D003562CytidineSLC28A1 protein results in increased transport of Cytidine10772724
D016047ZalcitabineSLC28A1 protein results in increased uptake of Zalcitabine8027026|8700147
D016047ZalcitabineZalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D016047ZalcitabineZalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]8700147
C014347decitabineSLC28A1 protein results in increased susceptibility to decitabine19139132
D003841DeoxycytidineSLC28A1 protein results in increased transport of Deoxycytidine10772724
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SLC28A1 mRNA28962523
D019259LamivudineLamivudine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]10772724
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SLC28A1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SLC28A1 mRNA26033743
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of SLC28A1 mRNA25198161
C039281furanfuran results in increased methylation of SLC28A1 gene22079235
C056507gemcitabinegemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]10772724
C056507gemcitabinegemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D007065IdoxuridineIdoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of SLC28A1 mRNA16507785
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC28A1 mRNA23557933
C089730rosiglitazonerosiglitazone results in decreased expression of SLC28A1 mRNA25572481
D012964SodiumSodium affects the reaction [SLC28A1 protein results in increased uptake of Azacitidine]19139132
D012964SodiumSodium affects the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
D012964SodiumSLC28A1 protein results in increased uptake of Sodium8700147
C016104sodium bichromatesodium bichromate results in decreased expression of SLC28A1 mRNA24612858
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC28A1 mRNA26377647
D013936ThymidineThymidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SLC28A1 mRNA29024780
D014520UrethaneUrethane results in decreased expression of SLC28A1 mRNA28818685
D014529UridineAdenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
D014529UridineCytarabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]10772724
D014529UridineCytidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
D014529Uridinegemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]10772724
D014529UridineLamivudine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]10772724
D014529UridineSLC28A1 protein results in increased transport of Uridine10772724
D014529UridineSLC28A1 protein results in increased uptake of Uridine9124315
D014529UridineSodium affects the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
D014529UridineThymidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
D014529UridineZidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
D014529UridineCytarabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D014529Uridinegemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D014529UridineIdoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D014529UridineSLC28A1 protein results in increased export of Uridine8700147
D014529UridineSLC28A1 protein results in increased uptake of Uridine8700147|8713072
D014529UridineZalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D014529UridineZalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]8700147
D014529UridineZidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D014529UridineZidovudine promotes the reaction [SLC28A1 protein results in increased export of Uridine]8700147
D014635Valproic AcidValproic Acid results in decreased expression of SLC28A1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of SLC28A1 gene29154799
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of SLC28A1 mRNA"25198161
D015215ZidovudineSLC28A1 protein affects the transport of Zidovudine9124315
D015215ZidovudineZidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]9124315
D015215ZidovudineSLC28A1 protein results in increased uptake of Zidovudine8027026|8700147
D015215ZidovudineZidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]8713072
D015215ZidovudineZidovudine promotes the reaction [SLC28A1 protein results in increased export of Uridine]8700147

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005337nucleoside transmembrane transporter activity-IBA21873635  
GO:0005337nucleoside transmembrane transporter activity-TAS9124315  
GO:0005415nucleoside:sodium symporter activity-IBA21873635  
GO:0005415nucleoside:sodium symporter activity-TAS-  
GO:0015389pyrimidine- and adenine-specific:sodium symporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS9124315  
GO:0015855pyrimidine nucleobase transport-IEA-  
GO:0015858nucleoside transport-TAS9124315  
GO:0072531pyrimidine-containing compound transmembrane transport-IEA-  
GO:1901642nucleoside transmembrane transport-IBA21873635  
GO:1901642nucleoside transmembrane transport-IEA-  
GO:1904823purine nucleobase transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016020membrane-TAS9124315  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-83936Transport of nucleosides and free purine and pyrimidine bases across the plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal