Gene: PLXNA4

91584
FAYV2820|PLEXA4|PLXNA4A|PLXNA4B|PRO34003
plexin A4
protein-coding
7q32.3
Ensembl:ENSG00000221866 MIM:604280 Vega:OTTHUMG00000155108 UniprotKB:Q9HCM2
NC_000007.14
SNP Mapped
7   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.265e-1 (AD)  1.933e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6946056chr7:132185838 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6968634chr7:132183083 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs896170chr7:132180333 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3734989chr7:132179832 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7808586chr7:132174737 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10277421chr7:132174318 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10273901chr7:132143808 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIN2B0.959
KCNB10.957
KIAA1549L0.955
KCNC10.954
MAP3K90.954
AAK10.953
CHRNB20.952
KLHL290.951
ATP2B30.951
ATP8A20.951

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.636
MYL3-0.634
COPZ2-0.629
YES1-0.618
RAB13-0.613
SNHG18-0.611
ROM1-0.603
AGTRAP-0.598
REST-0.596
RAI14-0.572

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PLXNA4 mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLXNA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLXNA4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PLXNA4 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLXNA4 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PLXNA4 gene25435355
D004958EstradiolEstradiol affects the expression of PLXNA4 mRNA23557687
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLXNA4 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PLXNA4 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of PLXNA4 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of PLXNA4 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of PLXNA4 mRNA29097150
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLXNA4 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of PLXNA4 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of PLXNA4 mRNA25979313
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLXNA4 mRNA19320972
D003471CuprizoneCuprizone results in decreased expression of PLXNA4 mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PLXNA4 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of PLXNA4 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLXNA4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLXNA4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PLXNA4 mRNA28628672
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PLXNA4 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of PLXNA4 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PLXNA4 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PLXNA4 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PLXNA4 mRNA29097150
D019833GenisteinGenistein affects the expression of PLXNA4 mRNA26865667
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLXNA4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLXNA4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PLXNA4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLXNA4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLXNA4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PLXNA4 mRNA28628672
D007854LeadLead affects the methylation of PLXNA4 gene24519525
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PLXNA4 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PLXNA4 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PLXNA4 mRNA24810058
C523799MRK 003MRK 003 results in decreased expression of PLXNA4 mRNA21169257
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of PLXNA4 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of PLXNA4 mRNA]"21673326
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLXNA4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PLXNA4 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of PLXNA4 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PLXNA4 gene25560391
C111237vorinostatvorinostat results in decreased expression of PLXNA4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017154semaphorin receptor activity-IBA21873635  
GO:0017154semaphorin receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007162negative regulation of cell adhesion-IBA21873635  
GO:0008360regulation of cell shape-IBA21873635  
GO:0021612facial nerve structural organization-IEA-  
GO:0021615glossopharyngeal nerve morphogenesis-IEA-  
GO:0021637trigeminal nerve structural organization-IEA-  
GO:0021644vagus nerve morphogenesis-IEA-  
GO:0021784postganglionic parasympathetic fiber development-IEA-  
GO:0021793chemorepulsion of branchiomotor axon-IEA-  
GO:0021960anterior commissure morphogenesis-IEA-  
GO:0030334regulation of cell migration-IBA21873635  
GO:0043087regulation of GTPase activity-IBA21873635  
GO:0048485sympathetic nervous system development-IEA-  
GO:0050772positive regulation of axonogenesis-IBA21873635  
GO:0050923regulation of negative chemotaxis-IEA-  
GO:0071526semaphorin-plexin signaling pathway-NAS19909241  
GO:1902287semaphorin-plexin signaling pathway involved in axon guidance-IBA21873635  
GO:1902287semaphorin-plexin signaling pathway involved in axon guidance-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002116semaphorin receptor complex-IBA21873635  
GO:0002116semaphorin receptor complex-TAS19909241  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-373755Semaphorin interactionsTAS
R-HSA-373755Semaphorin interactionsIEA
R-HSA-399954Sema3A PAK dependent Axon repulsionTAS
R-HSA-399955SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionIEA
R-HSA-399955SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionTAS
R-HSA-399956CRMPs in Sema3A signalingTAS
R-HSA-399956CRMPs in Sema3A signalingIEA
R-HSA-416700Other semaphorin interactionsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal