Gene info: ID 92737

Gene: DNER

GENE ID: 92737

Synonyms: UNQ26|bet

Description: delta/notch like EGF repeat containing

Gene type: protein-coding

Location: 2q36.3

dbXrefs: Ensembl:ENSG00000187957 MIM:607299 Vega:OTTHUMG00000153637 UniprotKB:Q8NFT8

RefSeq: NC_000002.12

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.662e-1 (AD) 1.389e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs7574501	chr2:229681362 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs2216249	chr2:229680640 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
VBP1	0.877
PSMD10	0.874
EIF3J	0.86
UBL3	0.854
UBE2A	0.854
YWHAQ	0.852
PRKRA	0.851
RAB7A	0.847
HNRNPK	0.846
HSBP1	0.845

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.753
OR4F29	-0.693
HMHB1	-0.209
OR6C74	-0.189
IFNG	-0.178
MTRNR2L6	-0.177
CLEC6A	-0.176
TTLL10	-0.169
PPBP	-0.167
FANCD2OS	-0.165

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C032668	1-nitropyrene	1-nitropyrene results in increased expression of DNER mRNA	19041380
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of DNER mRNA"	20406850
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of DNER mRNA"	24172598
C054121	3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone	DNER gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone	25622337
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of DNER mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of DNER protein	20106945
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of DNER mRNA	21298039
D001151	Arsenic	Arsenic affects the methylation of DNER gene	25304211
C487081	belinostat	belinostat results in increased expression of DNER mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DNER mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DNER mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DNER mRNA	22228805
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of DNER mRNA	20660070
C006780	bisphenol A	bisphenol A results in increased expression of DNER mRNA	28079927
C006780	bisphenol A	bisphenol A results in decreased expression of DNER mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of DNER mRNA	22079614
D002857	Chromium	Chromium results in decreased expression of DNER mRNA	21437242
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of DNER mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of DNER mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of DNER mRNA	20106945
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DNER mRNA]	27941970
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of DNER mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of DNER mRNA	27392435
D002117	Calcitriol	Calcitriol results in increased expression of DNER mRNA	16002434
D004237	Diuron	Diuron metabolite results in increased expression of DNER mRNA	24172598
C007556	domiphen	DNER gene SNP affects the susceptibility to domiphen	25622337
C118739	entinostat	entinostat results in increased expression of DNER mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
D004811	Epichlorohydrin	DNER gene SNP affects the susceptibility to Epichlorohydrin	25622337
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DNER mRNA	17942748
D005472	Fluorouracil	Fluorouracil results in increased expression of DNER mRNA	16510598
D006418	Heme	Heme metabolite results in decreased expression of DNER mRNA	19191707
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of DNER mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of DNER mRNA	27392435
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of DNER mRNA	20843944
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of DNER mRNA	26011545
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of DNER mRNA	24810058
D009532	Nickel	Nickel results in decreased expression of DNER mRNA	25583101
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of DNER mRNA	27935865
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of DNER mRNA	20971185
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of DNER mRNA"	18204070
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of DNER mRNA	26705709
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of DNER mRNA	26272509
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of DNER mRNA	27935865
C531249	Poly(amidoamine)	Poly(amidoamine) analog results in increased expression of DNER mRNA	23806026
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of DNER mRNA	22714537
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of DNER mRNA	20660070
C005556	propionaldehyde	propionaldehyde results in increased expression of DNER mRNA	26079696
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of DNER mRNA	23806026\|2589566
D012906	Smoke	Smoke results in increased expression of DNER mRNA	21095227
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DNER mRNA	21570461\|2468072
C009495	titanium dioxide	titanium dioxide results in decreased expression of DNER mRNA	23557971
D014212	Tretinoin	Tretinoin results in decreased expression of DNER mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of DNER mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in increased expression of DNER mRNA	19140230
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of DNER mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of DNER gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of DNER mRNA	23179753\|2438349
D014638	Vanadates	Vanadates results in increased expression of DNER mRNA	22714537
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNER mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of DNER mRNA	26272509
C088658	zoledronic acid	zoledronic acid results in increased expression of DNER mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004888	transmembrane signaling receptor activity	-	TAS	11950833
GO:0005112	Notch binding	-	IEA	-
GO:0005509	calcium ion binding	-	NAS	11950833
GO:0005515	protein binding	-	IPI	11950833
GO:0030276	clathrin binding	-	TAS	11950833

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001764	neuron migration	-	NAS	11950833
GO:0006897	endocytosis	-	NAS	11950833
GO:0007219	Notch signaling pathway	-	IEA	-
GO:0007220	Notch receptor processing	-	IEA	-
GO:0007416	synapse assembly	-	NAS	11950833
GO:0007417	central nervous system development	-	IEP	11950833
GO:0010001	glial cell differentiation	-	IEA	-
GO:0048741	skeletal muscle fiber development	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005769	early endosome	-	IDA	11950833
GO:0005886	plasma membrane	-	IDA	11950833
GO:0016021	integral component of membrane	-	IEA	-
GO:0030425	dendrite	-	IDA	11950833
GO:0043025	neuronal cell body	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-1980143	Signaling by NOTCH1	IEA
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23284291	Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (2012)	Hancock DB	PLoS Genet