Gene: SOCS6

9306
CIS-4|CIS4|HSPC060|SOCS-4|SOCS-6|SOCS4|SSI4|STAI4|STATI4
suppressor of cytokine signaling 6
protein-coding
18q22.2
Ensembl:ENSG00000170677 MIM:605118 Vega:OTTHUMG00000132816 UniprotKB:O14544
NC_000018.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.360e-1 (AD)  7.988e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7242186chr18:70314625 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MOB1A0.848
KLF30.821
LPCAT20.81
RB10.809
LHFPL20.809
RBM70.806
ATP7A0.803
HIPK30.802
RAP1B0.799
ATL30.799

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.401
OR4F29-0.374
HES5-0.335
KCNG2-0.276
ASPDH-0.257
KREMEN2-0.252
CRYBA2-0.252
ARSF-0.242
GSG1-0.242
NKX6-3-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SOCS6 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SOCS6 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SOCS6 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SOCS6 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of SOCS6 mRNA19774075
D001152ArsenicalsArsenicals results in decreased methylation of SOCS6 promoter23315758
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SOCS6 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SOCS6 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SOCS6 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SOCS6 mRNA"20018196
D004958EstradiolEstradiol results in increased expression of SOCS6 mRNA20106945
C006780bisphenol Abisphenol A results in increased methylation of SOCS6 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SOCS6 mRNA15336504
D002220CarbamazepineCarbamazepine affects the expression of SOCS6 mRNA24752500
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOCS6 gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of SOCS6 mRNA19549813
D003513CycloheximideCycloheximide results in increased expression of SOCS6 mRNA23237828
D016572CyclosporineCyclosporine results in increased expression of SOCS6 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of SOCS6 mRNA19770486
D002945CisplatinCisplatin results in decreased expression of SOCS6 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of SOCS6 mRNA24752500
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of SOCS6 mRNA"27840820
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SOCS6 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS6 mRNA17942748
D011345FenofibrateFenofibrate results in increased expression of SOCS6 mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in increased expression of SOCS6 mRNA]21318169
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOCS6 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SOCS6 mRNA20655997
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SOCS6 mRNA25613284
C045463leflunomideleflunomide results in increased expression of SOCS6 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SOCS6 gene20938992
C028007nickel monoxidenickel monoxide results in decreased expression of SOCS6 mRNA19167457
D010416PentachlorophenolPentachlorophenol results in increased expression of SOCS6 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of SOCS6 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of SOCS6 mRNA23091169
D011748PyrogallolPyrogallol results in increased expression of SOCS6 mRNA20362636
D011794QuercetinQuercetin results in decreased expression of SOCS6 mRNA21632981
D012834SilverSilver results in decreased expression of SOCS6 mRNA27131904
D012999SomanSoman results in increased expression of SOCS6 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOCS6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOCS6 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOCS6 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SOCS6 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SOCS6 mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of SOCS6 mRNA"19682533
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOCS6 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SOCS6 mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SOCS6 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of SOCS6 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SOCS6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SOCS6 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of SOCS6 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SOCS6 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SOCS6 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI24728074  25180228  
GO:00469351-phosphatidylinositol-3-kinase regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006952defense response-TAS9344848  
GO:0007259JAK-STAT cascade-TAS9344848  
GO:0010498proteasomal protein catabolic process-IMP20007709  
GO:0016567protein ubiquitination-IEA-  
GO:0040008regulation of growth-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0046854phosphatidylinositol phosphorylation-IBA21873635  
GO:0050868negative regulation of T cell activation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001772immunological synapse-IDA20007709  
GO:0005737cytoplasm-TAS9344848  
GO:0005829cytosol-TAS-  
GO:0005942phosphatidylinositol 3-kinase complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1433557Signaling by SCF-KITIEA
R-HSA-1433559Regulation of KIT signalingIEA
R-HSA-162582Signal TransductionIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal