Gene: B4GALT6

9331
B4Gal-T6|beta4Gal-T6
beta-1,4-galactosyltransferase 6
protein-coding
18q12.1
Ensembl:ENSG00000118276 MIM:604017 Vega:OTTHUMG00000131980 UniprotKB:Q9UBX8
NC_000018.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.470e-1 (AD)  2.125e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1667284chr18:31646245 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SGTB0.963
SLC4A100.957
TRUB10.952
OXR10.95
SMIM170.949
NBEA0.945
MYT1L0.945
CHM0.942
SCN8A0.942
STAU20.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.599
RAB13-0.564
ROM1-0.564
MYL3-0.555
AGTRAP-0.533
HEY2-0.528
RNF135-0.523
FLT3LG-0.522
COPZ2-0.511
CHST14-0.508

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of B4GALT6 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of B4GALT6 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of B4GALT6 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of B4GALT6 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of B4GALT6 mRNA24449571
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of B4GALT6 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of B4GALT6 mRNA20127859
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of B4GALT6 mRNA15034205
D004958EstradiolEstradiol affects the expression of B4GALT6 mRNA23557687
C053541bicalutamidebicalutamide results in increased expression of B4GALT6 mRNA16631469
C006780bisphenol Abisphenol A affects the expression of B4GALT6 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of B4GALT6 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of B4GALT6 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of B4GALT6 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of B4GALT6 gene28505145
C006780bisphenol Abisphenol A results in decreased methylation of B4GALT6 gene28505145
D000069286BortezomibBortezomib results in increased expression of B4GALT6 mRNA20977926
C018475butyraldehydebutyraldehyde results in decreased expression of B4GALT6 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of B4GALT6 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of B4GALT6 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of B4GALT6 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of B4GALT6 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of B4GALT6 mRNA25562108
D003907DexamethasoneDexamethasone results in decreased expression of B4GALT6 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of B4GALT6 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of B4GALT6 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of B4GALT6 mRNA28031460
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of B4GALT6 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of B4GALT6 mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of B4GALT6 mRNA16002434
D004147DioxinsDioxins affects the expression of B4GALT6 mRNA20463971
D004178DiquatDiquat affects the expression of B4GALT6 mRNA22814884
D004237DiuronDiuron results in increased expression of B4GALT6 mRNA21551480
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of B4GALT6 mRNA20938992
C039281furanfuran results in increased expression of B4GALT6 mRNA27387713
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of B4GALT6 gene28505145
C010176halofuginonehalofuginone results in increased expression of B4GALT6 mRNA17180598
D017313FenretinideFenretinide results in decreased expression of B4GALT6 mRNA28973697
D017313FenretinideFenretinide results in increased expression of B4GALT6 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of B4GALT6 mRNA26191083
C544151jinfukangjinfukang results in decreased expression of B4GALT6 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of B4GALT6 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of B4GALT6 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of B4GALT6 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of B4GALT6 mRNA15674844
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of B4GALT6 mRNA17616710
D009966OrphenadrineOrphenadrine affects the expression of B4GALT6 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of B4GALT6 mRNA25729387
C006253pirinixic acidpirinixic acid results in increased expression of B4GALT6 mRNA17426115
D011374ProgesteroneProgesterone results in decreased expression of B4GALT6 mRNA19693291
D011374ProgesteroneProgesterone results in decreased expression of B4GALT6 mRNA19690047
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of B4GALT6 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of B4GALT6 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of B4GALT6 mRNA19073995
D012906SmokeSmoke results in increased expression of B4GALT6 mRNA21095227
C009277sodium arsenatesodium arsenate results in increased expression of B4GALT6 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of B4GALT6 mRNA28595984
C017947sodium arsenitesodium arsenite results in decreased methylation of B4GALT6 gene24118411
D013739TestosteroneTestosterone results in increased expression of B4GALT6 mRNA19693291
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of B4GALT6 mRNA]20032058
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of B4GALT6 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of B4GALT6 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of B4GALT6 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of B4GALT6 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of B4GALT6 mRNA11752688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of B4GALT6 mRNA20558275|2095900
D013853ThioacetamideThioacetamide results in increased expression of B4GALT6 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of B4GALT6 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of B4GALT6 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of B4GALT6 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of B4GALT6 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of B4GALT6 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of B4GALT6 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of B4GALT6 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003831beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity-TAS-  
GO:0008378galactosyltransferase activity-IDA10320813  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001572lactosylceramide biosynthetic process-IDA10320813  
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006486protein glycosylation-IEA-  
GO:0018146keratan sulfate biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
KEGG ID KEGG Term
hsa00600Sphingolipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638074Keratan sulfate/keratin metabolismTAS
R-HSA-2022854Keratan sulfate biosynthesisTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-913709O-linked glycosylation of mucinsTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-975576N-glycan antennae elongation in the medial/trans-GolgiTAS
R-HSA-975577N-Glycan antennae elongationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal