Gene: MUC16

94025
CA125
mucin 16, cell surface associated
protein-coding
19p13.2
Ensembl:ENSG00000181143 MIM:606154 Vega:OTTHUMG00000169191 UniprotKB:Q8WXI7
NG_055257.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.077e-1 (AD)  6.264e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10412487chr19:8862541 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNASE90.967
CDY2A0.961
OR5F10.961
TSPY30.961
OR4C460.961
OR5M10.961
OR5T20.961
KRTAP6-20.961
OR4C120.961
OR5W20.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM221-0.293
C16orf95-0.292
HHATL-0.282
SLC1A4-0.28
HDDC3-0.28
C1orf53-0.278
HSPB2-0.276
TM7SF2-0.276
ADCY2-0.268
CORO2B-0.266

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04964OregovomabBiotechDrug-InvestigationalTarget
ID Drug Name Action PubMed
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of MUC16 mRNA"24172598
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MUC16 gene27153756
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MUC16 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MUC16 gene25435355
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of MUC16 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of MUC16 mRNA22576693
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of MUC16 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of MUC16 mRNA25181051
D001888Boric AcidsBoric Acids results in decreased expression of MUC16 mRNA21060261
D002064Buserelin[Buserelin co-treated with CGB3 protein] results in increased expression of MUC16 mRNA19955106
C031180chrysenechrysene results in increased expression of MUC16 mRNA26377693
D018639Contact Lens SolutionsContact Lens Solutions results in decreased expression of MUC16 protein21060261
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of MUC16 protein23811945
D002945Cisplatin[Paclitaxel co-treated with Cisplatin] results in decreased expression of MUC16 protein8751544
D004041Dietary FatsDietary Fats results in decreased expression of MUC16 mRNA25016146
D004237DiuronDiuron metabolite results in increased expression of MUC16 mRNA24172598
D017313FenretinideFenretinide results in decreased expression of MUC16 mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of MUC16 mRNA19376150
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of MUC16 mRNA"26377693
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MUC16 mRNA"25554681
D017239Paclitaxel[Paclitaxel co-treated with Cisplatin] results in decreased expression of MUC16 protein8751544
D017239PaclitaxelPaclitaxel results in decreased expression of MUC16 protein11706781
D052638Particulate MatterParticulate Matter results in decreased expression of MUC16 mRNA23722391
D052638Particulate MatterParticulate Matter results in increased expression of MUC16 mRNA23722391
D010936Plant ExtractsPlant Extracts results in decreased expression of MUC16 mRNA23557933
D011239PrednisolonePrednisolone results in decreased expression of MUC16 protein12169874
D053260SootSoot results in decreased expression of MUC16 mRNA26551751
C009495titanium dioxidetitanium dioxide affects the expression of MUC16 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MUC16 mRNA25788831
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MUC16 mRNA20133372
D014212TretinoinTretinoin results in increased expression of MUC16 mRNA16249480
D014635Valproic AcidValproic Acid results in increased expression of MUC16 mRNA23527032
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of MUC16 mRNA23722391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of MUC16 mRNA23722391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14676194  
GO ID GO Term Qualifier Evidence PubMed
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0007155cell adhesion-NAS14676194  
GO:0016266O-glycan processing-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0019898extrinsic component of membrane-IDA12766047  
GO:0031982vesicle-HDA19190083  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083625Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)TAS
R-HSA-5083632Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)TAS
R-HSA-5083636Defective GALNT12 causes colorectal cancer 1 (CRCS1)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5621480Dectin-2 familyTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-913709O-linked glycosylation of mucinsTAS
R-HSA-977068Termination of O-glycan biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal