Gene: NCR2

9436
CD336|LY95|NK-p44|NKP44|dJ149M18.1
natural cytotoxicity triggering receptor 2
protein-coding
6p21.1
Ensembl:ENSG00000096264 MIM:604531 Vega:OTTHUMG00000014678 UniprotKB:O95944
NC_000006.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.455e-1 (AD)  4.922e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6929418chr6:41339856 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UGT1A40.609
OR5B30.446
MAGEA110.444
KLK30.444
KLK20.442
GCNT30.434
SERPINB110.423
CXorf660.419
TGM40.419
TRIML10.417

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACY3-0.193
CLDN20-0.186
POLR2J3-0.179
ALG1L-0.176
HIST1H3C-0.165
TPSB2-0.158
FRA10AC1-0.156
EMILIN3-0.155
RNASE7-0.154
PAX8-0.151

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of NCR2 mRNA18692832
D003471CuprizoneCuprizone affects the expression of NCR2 mRNA27523638
D009173Mycophenolic AcidMycophenolic Acid results in decreased expression of NCR220736080
C046012pentanalpentanal results in increased expression of NCR2 mRNA26079696
D010936Plant ExtractsPlant Extracts results in decreased expression of NCR2 mRNA23557933
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of NCR2 mRNA18692832
D019287Zinc SulfateZinc Sulfate results in increased expression of NCR2 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS10049942  
GO:0005515protein binding-IPI10049942  14707061  22021614  23958951  
GO ID GO Term Qualifier Evidence PubMed
GO:0006968cellular defense response-TAS10049942  
GO:0007165signal transduction-TAS10049942  
GO:0045087innate immune response-TAS-  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS10049942  
KEGG ID KEGG Term
hsa04650Natural killer cell mediated cytotoxicity
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-2172127DAP12 interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23459936Exploring the genetic basis of chronic periodontitis: a genome-wide association study. (2013 Jun 1)Divaris KHum Mol Genet