Gene: AKAP6

9472
ADAP100|ADAP6|AKAP100|PRKA6|mAKAP
A-kinase anchoring protein 6
protein-coding
14q12
Ensembl:ENSG00000151320 MIM:604691 Vega:OTTHUMG00000140207 UniprotKB:Q13023
NC_000014.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.254e-2 (AD)  7.854e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17412116chr14:32497142 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRPK20.939
PPM1A0.939
CCSER20.937
DNAJC60.935
EIF4G30.935
PRUNE20.934
MYO5A0.933
PIK3CB0.931
AKT30.931
MAP1B0.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.522
OR4F29-0.506
RHOD-0.42
CSAG1-0.417
RNF135-0.406
RAB13-0.404
EVC2-0.4
SOD3-0.396
CHST14-0.386
IMPA2-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of AKAP6 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AKAP6 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of AKAP6 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AKAP6 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AKAP6 mRNA17484886
D003471CuprizoneCuprizone results in decreased expression of AKAP6 mRNA26577399
D003474CurcuminCurcumin results in increased expression of AKAP6 mRNA18421014
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]18200517
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AKAP6 mRNA]11007951
C014347decitabinedecitabine results in decreased methylation of AKAP6 gene27923600
D004041Dietary FatsDietary Fats results in increased expression of AKAP6 mRNA18042831
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of AKAP6 mRNA"22485181
D019833GenisteinGenistein results in increased expression of AKAP6 protein24552547
D007854LeadLead affects the expression of AKAP6 mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of AKAP6 mRNA"20188158
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of AKAP6 mRNA"29244179
D000073878Palm OilPalm Oil results in increased expression of AKAP6 mRNA18042831
C006253pirinixic acidpirinixic acid results in increased expression of AKAP6 mRNA20813756
C009277sodium arsenatesodium arsenate results in increased expression of AKAP6 mRNA21795629
D053260SootSoot results in increased expression of AKAP6 mRNA26551751
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AKAP6 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AKAP6 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AKAP6 mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of AKAP6 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AKAP6 mRNA20133372
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA18200517
D014635Valproic AcidValproic Acid affects the expression of AKAP6 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17923693  23414517  
GO:0008179adenylate cyclase binding-ISS-  
GO:0032947protein-containing complex scaffold activity-ISS-  
GO:0034237protein kinase A regulatory subunit binding-ISS-  
GO:0043495protein membrane anchor-ISS10413680  
GO:0044325ion channel binding-IBA21873635  
GO:0044325ion channel binding-IPI10830164  
GO:0051018protein kinase A binding-IBA21873635  
GO:0051018protein kinase A binding-NAS10413680  
GO:0051018protein kinase A binding-TAS10830164  
GO ID GO Term Qualifier Evidence PubMed
GO:0001508action potential-IC11299204  
GO:0006605protein targeting-NAS7721854  10413680  
GO:0010738regulation of protein kinase A signaling-ISS-  
GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum-IC-  
GO:0019933cAMP-mediated signaling-NAS16177794  
GO:0030307positive regulation of cell growth-ISS16177794  
GO:0032516positive regulation of phosphoprotein phosphatase activity-ISS-  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-ISS-  
GO:0060306regulation of membrane repolarization-IDA11299204  
GO:0060316positive regulation of ryanodine-sensitive calcium-release channel activity-ISS-  
GO:0061051positive regulation of cell growth involved in cardiac muscle cell development-ISS-  
GO:0070886positive regulation of calcineurin-NFAT signaling cascade-ISS-  
GO:0071320cellular response to cAMP-IDA11299204  
GO:0071345cellular response to cytokine stimulus-ISS16177794  
GO:1901381positive regulation of potassium ion transmembrane transport-IDA11299204  
GO:1902261positive regulation of delayed rectifier potassium channel activity-IDA11299204  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IDA10413680  
GO:0005737cytoplasm-ISS-  
GO:0005901caveola-ISS-  
GO:0014701junctional sarcoplasmic reticulum membrane-ISS-  
GO:0014704intercalated disc-ISS9679148  
GO:0016529sarcoplasmic reticulum-IBA21873635  
GO:0016529sarcoplasmic reticulum-IDA7721854  10830164  
GO:0030315T-tubule-ISS9679148  
GO:0031965nuclear membrane-IEA-  
GO:0034704calcium channel complex-IDA10830164  
GO:0048471perinuclear region of cytoplasm-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IDA11590243  
GO:0048471perinuclear region of cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal