Gene: RPH3AL

9501
NOC2
rabphilin 3A like (without C2 domains)
protein-coding
17p13.3
Ensembl:ENSG00000181031 MIM:604881 Vega:OTTHUMG00000090273 UniprotKB:Q9UNE2
NG_023031.1
SNP Mapped
4   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.290e-1 (AD)  4.121e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9319629chr17:373191 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12450789chr17:220063 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11150884chr17:212735 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs11654695chr17:209189 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH220.667
N4BP30.667
MCAT0.662
RELL20.658
RTP10.656
FADS60.656
TANGO20.652
TMEM229B0.651
SLC27A40.649
LYRM40.647

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.401
BAZ1A-0.4
NFIA-0.391
YES1-0.389
ZHX2-0.385
RAI14-0.381
OTUD7B-0.367
SOWAHC-0.361
CPM-0.36
ARHGAP19-0.357

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of RPH3AL mRNA"19162173
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RPH3AL mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPH3AL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPH3AL mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPH3AL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPH3AL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPH3AL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPH3AL mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RPH3AL mRNA26690555|2906747
D000082AcetaminophenAcetaminophen affects the expression of RPH3AL mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RPH3AL mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of RPH3AL mRNA22323515
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPH3AL mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RPH3AL mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RPH3AL mRNA"26238291
D004958EstradiolEstradiol affects the expression of RPH3AL mRNA22574217
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of RPH3AL mRNA19619570
D004958EstradiolEstradiol results in increased expression of RPH3AL mRNA19619570
C006780bisphenol Abisphenol A affects the expression of RPH3AL mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RPH3AL mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of RPH3AL mRNA22079614
D019256Cadmium ChlorideCadmium Chloride affects the expression of RPH3AL mRNA23828170
D007631ChlordeconeRPH3AL gene SNP affects the susceptibility to Chlordecone25622337
C018021cobaltous chloridecobaltous chloride results in decreased expression of RPH3AL mRNA19376846
D003471CuprizoneCuprizone results in decreased expression of RPH3AL mRNA27523638
D003471CuprizoneCuprizone results in increased expression of RPH3AL mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of RPH3AL mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of RPH3AL mRNA25562108|2798913
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RPH3AL mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RPH3AL mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RPH3AL mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of RPH3AL mRNA28302478
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of RPH3AL mRNA17072980
C024629dimethyl phthalatedimethyl phthalate affects the expression of RPH3AL mRNA26924002
C118739entinostatentinostat results in decreased expression of RPH3AL mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPH3AL mRNA"27188386
D005485FlutamideFlutamide results in decreased expression of RPH3AL mRNA24136188
C004312glycidolglycidol results in increased expression of RPH3AL mRNA24915197
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RPH3AL mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RPH3AL mRNA28628672
D007854LeadLead results in decreased expression of RPH3AL mRNA19921347
D008727MethotrexateMethotrexate results in increased expression of RPH3AL mRNA24449571
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of RPH3AL mRNA24810058
C119536nickel acetatenickel acetate affects the expression of RPH3AL mRNA23828170
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of RPH3AL mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPH3AL mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of RPH3AL mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of RPH3AL mRNA21061450
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of RPH3AL mRNA19162173
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RPH3AL mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RPH3AL mRNA25351596
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of RPH3AL mRNA"26680231
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of RPH3AL mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RPH3AL mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPH3AL mRNA21215274
D014635Valproic AcidValproic Acid affects the expression of RPH3AL mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0008092cytoskeletal protein binding-TAS9367993  
GO:0017137Rab GTPase binding-IEA-  
GO:0030274LIM domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IEA-  
GO:0006887exocytosis-IEA-  
GO:0017158regulation of calcium ion-dependent exocytosis-IEA-  
GO:0042493response to drug-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway-IEA-  
GO:0050714positive regulation of protein secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS9367993  
GO:0030658transport vesicle membrane-IEA-  
GO:0030667secretory granule membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal