Gene: GMFG

9535
GMF-GAMMA
glia maturation factor gamma
protein-coding
19q13.2
Ensembl:ENSG00000130755 MIM:604104 Vega:OTTHUMG00000182811 UniprotKB:O60234
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.040e-1 (AD)  8.658e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3786949chr19:39335839 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VAMP80.858
CYBA0.855
LST10.844
PYCARD0.833
ARHGDIB0.824
GPSM30.823
SPI10.823
HLA-DPB10.821
ARPC1B0.82
WAS0.819

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.439
ST6GAL2-0.436
CALHM1-0.426
DNAJC5G-0.419
WNT7A-0.417
OPRD1-0.416
ADRA1D-0.413
CHRNA4-0.41
KCNA2-0.41
MARCH4-0.409

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GMFG mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GMFG mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GMFG mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GMFG mRNA22230336
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GMFG mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GMFG mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GMFG mRNA24449571
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of GMFG mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to GMFG promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GMFG mRNA19770486
C006780bisphenol Abisphenol A affects the expression of GMFG mRNA21786754
C018475butyraldehydebutyraldehyde results in increased expression of GMFG mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of GMFG mRNA22110744
D019327Copper SulfateCopper Sulfate results in increased expression of GMFG mRNA19549813
D003471CuprizoneCuprizone results in increased expression of GMFG mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of GMFG mRNA19770486
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GMFG mRNA27392435
D002945CisplatinCisplatin results in increased expression of GMFG mRNA27392435
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GMFG mRNA25380136
D004397FonofosFonofos results in decreased methylation of GMFG promoter22847954
D005839GentamicinsGentamicins results in increased expression of GMFG mRNA22061828
D005897GlafenineGlafenine results in increased expression of GMFG mRNA24136188
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GMFG mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GMFG mRNA24796395|2675264
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GMFG mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GMFG mRNA25380136
D009532NickelNickel results in increased expression of GMFG mRNA25583101
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of GMFG mRNA17616710
D010278ParathionParathion results in decreased methylation of GMFG promoter22847954
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of GMFG protein19854247
D010656PhenylephrinePhenylephrine results in increased expression of GMFG mRNA18158353
C006253pirinixic acidpirinixic acid results in increased expression of GMFG mRNA18301758
D011794QuercetinQuercetin results in increased expression of GMFG mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GMFG mRNA25895662
D018038Sodium SeleniteSodium Selenite results in increased expression of GMFG mRNA18175754
D012999SomanSoman results in increased expression of GMFG mRNA19281266
C012568terbufosterbufos results in decreased methylation of GMFG promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GMFG mRNA19770486
C066340tolcaponetolcapone results in decreased expression of GMFG mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GMFG mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of GMFG mRNA24383497|2800136
C025643vinclozolinvinclozolin affects the expression of GMFG mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of GMFG mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0004860protein kinase inhibitor activity-TAS8639570  
GO:0008047enzyme activator activity-TAS8798479  
GO:0008083growth factor activity-IEA-  
GO:0071933Arp2/3 complex binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-TAS7598724  
GO:0006469negative regulation of protein kinase activity-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0034316negative regulation of Arp2/3 complex-mediated actin nucleation-IEA-  
GO:0043085positive regulation of catalytic activity-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0071846actin filament debranching-IEA-  
GO:2000249regulation of actin cytoskeleton reorganization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0034774secretory granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal