Gene: PTGES

9536
MGST-IV|MGST1-L1|MGST1L1|MPGES|PGES|PIG12|PP102|PP1294|TP53I12|mPGES-1
prostaglandin E synthase
protein-coding
9q34.11
Ensembl:ENSG00000148344 MIM:605172 Vega:OTTHUMG00000020791 UniprotKB:O14684
NC_000009.12
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.767e-1 (AD)  5.855e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4837408chr9:129751861 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10819563chr9:129742923 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HTR1A0.712
CNGB10.681
SDK10.669
GPR830.668
FAM163A0.654
SP80.642
SSTR40.641
PIP5K1B0.639
SLC24A40.637
HS6ST30.636

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTNNA3-0.362
MOBP-0.359
ZFP57-0.346
BCAS1-0.344
LPAR1-0.34
FAM107B-0.336
C19orf18-0.331
HSD17B3-0.331
SOX3-0.329
PAIP2B-0.329

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of PTGES mRNA"23958786
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PTGES mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PTGES mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PTGES mRNA"20566336
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PTGES mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PTGES mRNA"19167446
C04456324-hydroxycholesterol24-hydroxycholesterol results in increased expression of PTGES mRNA24802026
C04456324-hydroxycholesterolQuercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of PTGES mRNA]24802026
C04456324-hydroxycholesterolQuercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of PTGES mRNA]24802026
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of PTGES mRNA24802026
C07699627-hydroxycholesterolQuercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]24802026
C07699627-hydroxycholesterolQuercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]24802026
C0038982-anisidine2-anisidine results in increased expression of PTGES mRNA28089782
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of PTGES mRNA20840853
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in decreased expression of PTGES mRNA20382172
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PTGES mRNA16788091
C0473683-methylquercetin3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]21341175
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of PTGES mRNA19191707
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of PTGES mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PTGES mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of PTGES mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTGES mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of PTGES mRNA28054265|2845410
C006632arsenic trioxide[Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of PTGES mRNA18922899
C500823arvelexinarvelexin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]25451575
C500823arvelexinarvelexin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES protein]25451575
C500823arvelexinarvelexin analog results in decreased stability of PTGES mRNA25451575
C500823arvelexinarvelexin analog inhibits the reaction [Carrageenan results in increased expression of PTGES protein]25451575
C517830arzanolarzanol results in decreased activity of PTGES protein20933508
D001241AspirinAspirin results in decreased expression of PTGES mRNA19880272
D001241AspirinAspirin results in decreased expression of PTGES protein19880272
C019264avermectinavermectin results in increased expression of PTGES mRNA24134892
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTGES mRNA21569818|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PTGES mRNA"20382639
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PTGES mRNA19619570
D004958EstradiolEstradiol results in increased expression of PTGES mRNA19619570|2686566
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of PTGES mRNA25270620
C006780bisphenol Abisphenol A results in increased expression of PTGES mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of PTGES mRNA25181051
C025703bleomycetinbleomycetin results in decreased expression of PTGES mRNA21040473
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PTGES mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of PTGES mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PTGES promoter22457795
C459604candoxincandoxin results in decreased expression of PTGES mRNA16309724
D002351Carrageenanarvelexin analog inhibits the reaction [Carrageenan results in increased expression of PTGES protein]25451575
D002351CarrageenanCarrageenan results in increased expression of PTGES protein17258197|2545157
D000068579Celecoxib[Celecoxib co-treated with docetaxel] results in decreased expression of PTGES protein16052515
D000068579CelecoxibCelecoxib results in decreased expression of PTGES mRNA16273290
D002737ChloropreneChloroprene results in decreased expression of PTGES mRNA23125180
C011724cholest-5-en-3 beta,7 alpha-diol"cholest-5-en-3 beta,7 alpha-diol results in increased expression of PTGES mRNA"24802026
C011724cholest-5-en-3 beta,7 alpha-diol"Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of PTGES mRNA]"24802026
D002809Chondroitin Sulfates[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of PTGES protein17605605
D002809Chondroitin Sulfates[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein17605605
C039671ciglitazone[Cisplatin co-treated with ciglitazone] results in decreased expression of PTGES21681689
D002996ClomipheneClomiphene results in decreased expression of PTGES mRNA26865669
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of PTGES mRNA]22155307
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]21954917
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]19428335
C007095cobaltiprotoporphyrinHMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]]21954917
C007095cobaltiprotoporphyrinHMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]]19428335
C018021cobaltous chloridePTGES protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A mRNA]20042640
D003300Copper[Copper results in increased activity of TP53 protein] which results in increased expression of PTGES mRNA16391388
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of PTGES mRNA26033743
D003300CopperCopper deficiency results in increased expression of PTGES mRNA26033743
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PTGES mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of PTGES mRNA19167446
C015763cumene[cumene co-treated with KRAS gene mutant form] results in increased expression of PTGES mRNA18648096
D003474CurcuminCurcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]27645308
D003474CurcuminCurcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]19243473
D016572CyclosporineCyclosporine results in decreased expression of PTGES mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PTGES mRNA23914054
C014347decitabinedecitabine results in increased expression of PTGES mRNA15251184
C014347decitabine[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PTGES mRNA15251184
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PTGES mRNA16556975
C007262deoxynivalenoldeoxynivalenol results in decreased expression of PTGES mRNA25549547
C007262deoxynivalenoldeoxynivalenol results in increased expression of PTGES mRNA21873375|2554954
D003907DexamethasoneDexamethasone inhibits the reaction [IL1B protein results in increased expression of PTGES]25314295
D016264Dextran SulfateDextran Sulfate results in increased expression of PTGES protein20132809
D016264Dextran Sulfateresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]20132809
D016264Dextran SulfateDextran Sulfate results in increased expression of PTGES protein19228061
D016264Dextran Sulfateresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]19228061
C023614dibenzofurandibenzofuran analog results in increased expression of PTGES mRNA20566336
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PTGES mRNA21266533
D002945Cisplatin[Cisplatin co-treated with ciglitazone] results in decreased expression of PTGES21681689
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PTGES mRNA27392435
D002945CisplatinCisplatin results in increased expression of PTGES mRNA27392435
D002945CisplatinCisplatin results in increased expression of PTGES protein20844471
D002945CisplatinPTGES protein promotes the reaction [Cisplatin results in increased expression of IL1B protein]20844471
D002945CisplatinPTGES protein promotes the reaction [Cisplatin results in increased expression of TNF protein]20844471
D002945CisplatinCisplatin results in decreased expression of PTGES protein21272267
D004008DiclofenacDiclofenac results in decreased expression of PTGES mRNA19393675
D004008Diclofenac[Diclofenac results in decreased expression of PTGES mRNA] which results in decreased abundance of Dinoprostone19393675
D004041Dietary FatsDietary Fats results in decreased expression of PTGES mRNA19030233
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of PTGES mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of PTGES mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PTGES mRNA26865669
D004237DiuronDiuron results in increased expression of PTGES mRNA21551480
C067311docetaxel[Celecoxib co-treated with docetaxel] results in decreased expression of PTGES protein16052515
C118739entinostatentinostat results in increased expression of PTGES mRNA27188386
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of PTGES mRNA]21233418
D004967EstrogensEstrogens results in increased expression of PTGES mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PTGES mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PTGES mRNA17942748
D008656MestranolMestranol results in increased expression of PTGES mRNA26865669
C070081fulvestrantfulvestrant results in decreased expression of PTGES mRNA26865669
D019833GenisteinGenistein results in increased expression of PTGES mRNA26865669
D005839GentamicinsGentamicins results in decreased expression of PTGES mRNA22061828
C007845gingerolgingerol results in decreased expression of PTGES protein27645308
C007845gingerolgingerol results in increased expression of PTGES mRNA27645308
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PTGES mRNA16556975
D005944Glucosamine[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of PTGES protein17605605
D005944Glucosamine[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein17605605
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of PTGES mRNA]22089456
D006052Gold Sodium ThiomalateGold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES]25314295
D006534Heptachlor EpoxideHeptachlor Epoxide results in increased expression of PTGES mRNA25270620
D006589HexestrolHexestrol results in increased expression of PTGES mRNA26865669
D017313FenretinideFenretinide results in increased expression of PTGES mRNA28973697
C030374indoleindole analog results in decreased activity of PTGES protein21323313
D007213IndomethacinIndomethacin results in increased expression of PTGES mRNA28201806
C051890irinotecanirinotecan metabolite results in increased expression of PTGES mRNA15956246
C051890irinotecanirinotecan results in increased expression of PTGES mRNA15956246
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PTGES mRNA27392435
C544151jinfukangjinfukang results in increased expression of PTGES mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of PTGES mRNA26752646
C006552kaempferolkaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]21341175
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in decreased expression of PTGES mRNA"21480431
C440499lipopolysaccharide, Escherichia coli O111 B4"PTGES results in increased susceptibility to lipopolysaccharide, Escherichia coli O111 B4"25164664
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTGES protein17038636
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES protein]17038636
D008070Lipopolysaccharides3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]21341175
D008070Lipopolysaccharidesarvelexin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]25451575
D008070Lipopolysaccharidesarvelexin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES protein]25451575
D008070Lipopolysaccharideskaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]21341175
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTGES mRNA20453108|2134117
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTGES protein25451575
D008070LipopolysaccharidesMST1R gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]20453108
D008070Lipopolysaccharides[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES mRNA21669866
D008070Lipopolysaccharides[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES protein21669866
D008070LipopolysaccharidesTLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]23000425
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTGES mRNA17927823
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTGES protein17927823
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]17927823
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES protein]17927823
D008070LipopolysaccharidesCurcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]19243473
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTGES16251433
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PTGES mRNA19243473
D018021Lithium ChlorideLithium Chloride results in increased expression of PTGES protein19692487
D018021Lithium Chloride[Lithium Chloride results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone19692487
D018021Lithium ChloridePTGES protein promotes the reaction [Lithium Chloride results in decreased expression of AQP2 mRNA]19692487
D018021Lithium ChloridePTGES protein promotes the reaction [Lithium Chloride results in decreased expression of AQP2 protein]19692487
D018021Lithium ChloridePTGES protein promotes the reaction [Lithium Chloride results in decreased expression of SLC12A1 protein]19692487
C010480lupeollupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]27235710
C013099mancozeblupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]27235710
C013099mancozebmancozeb results in increased expression of PTGES mRNA27235710
C065757meloxicammeloxicam results in decreased expression of PTGES mRNA21270428
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PTGES mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PTGES mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PTGES mRNA"20188158
C008493methylselenic acidmethylselenic acid results in decreased expression of PTGES mRNA11830524
C008493methylselenic acidmethylselenic acid results in decreased expression of PTGES mRNA21669866
C060893MK-886MK-886 results in decreased activity of PTGES protein20933508|2545157
C060893MK-886MK-886 analog results in decreased activity of PTGES protein21323313
C060893MK-886MK-886 results in decreased activity of PTGES protein21466167
D009151Mustard GasMustard Gas results in increased expression of PTGES mRNA25102026
C528911N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide"N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide results in increased expression of PTGES mRNA"18287210
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PTGES mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PTGES mRNA"25554681
D009281NaphthalenesNaphthalenes results in increased expression of PTGES protein17337753
D009532NickelNickel results in increased expression of PTGES mRNA23195993|2558310
D009532NickelNickel results in increased expression of PTGES mRNA12540486|2745219
D009538NicotineNicotine results in decreased expression of PTGES mRNA24380835
D009538NicotineNicotine results in decreased expression of PTGES protein24380835
C012655nimesulidenimesulide results in decreased expression of PTGES protein16388017
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PTGES mRNA19074003
D010100OxygenHIF1A protein promotes the reaction [[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone]20042640
D010100OxygenOxygen deficiency results in increased expression of PTGES mRNA20042640
D010100OxygenOxygen deficiency results in increased expression of PTGES protein20042640
D010100Oxygen[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone20042640
D010100OxygenPTGES protein promotes the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]20042640
D010100OxygenPTGES protein promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]20042640
C002669parthenolide[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES mRNA21669866
C002669parthenolide[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES protein21669866
D015232Dinoprostonecobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]19428335
D015232DinoprostoneHIF1A protein promotes the reaction [[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone]20042640
D015232DinoprostoneHMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]]19428335
D015232Dinoprostone[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone19428335
D015232Dinoprostone[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone20042640
D015232DinoprostonePTGES results in increased abundance of Dinoprostone17369862
D015232Dinoprostone[GPX2 protein affects the expression of PTGES protein] which affects the metabolism of Dinoprostone18479189
D015232Dinoprostone[IL6 protein results in increased expression of PTGES mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone24285838
D015232Dinoprostone[Lithium Chloride results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone19692487
D015232DinoprostonePTGES protein affects the reaction [Tetrachlorodibenzodioxin results in increased abundance of Dinoprostone]22430074
D015232Dinoprostone[Tetrachlorodibenzodioxin results in increased expression of PTGES mRNA] which results in increased chemical synthesis of Dinoprostone22430074
D015232Dinoprostone[Diclofenac results in decreased expression of PTGES mRNA] which results in decreased abundance of Dinoprostone19393675
D015232DinoprostonePTGES protein results in increased chemical synthesis of Dinoprostone20840853|2531429
D044262Prostaglandin H2Prostaglandin H2 analog results in decreased activity of PTGES protein21323313
D044262Prostaglandin H2PTGES protein results in increased metabolism of Prostaglandin H220840853
D010862PilocarpinePilocarpine results in increased expression of PTGES mRNA15193289
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PTGES mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PTGES mRNA20813756
D011374ProgesteroneProgesterone results in increased expression of PTGES mRNA18692832
D015237DinoprostDinoprost results in decreased expression of PTGES mRNA20484870
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PTGES mRNA27029645
D011794QuercetinQuercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of PTGES mRNA]24802026
D011794QuercetinQuercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]24802026
D011794Quercetin"Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of PTGES mRNA]"24802026
D011794QuercetinQuercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of PTGES mRNA]24802026
D011794QuercetinQuercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]24802026
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGES mRNA19059307
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of PTGES mRNA26865669
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of PTGES mRNA19167446
C059514resveratrolresveratrol results in increased expression of PTGES mRNA25888808
C059514resveratrolresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]20132809
C059514resveratrolresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]19228061
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]17927823
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES protein]17927823
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of PTGES mRNA19244175
D012643SeleniumSelenium results in increased expression of PTGES mRNA19244175
D012643Selenium[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES mRNA21669866
D012643Selenium[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES protein21669866
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of PTGES mRNA"24160326
C040115shogaolshogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein]27645308
C040115shogaolshogaol results in decreased expression of PTGES mRNA27645308
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PTGES mRNA25895662
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES protein]17038636
D019821SimvastatinSimvastatin results in decreased expression of PTGES protein17038636
C016104sodium bichromatesodium bichromate results in increased expression of PTGES mRNA24612858
C009279sodium bisulfite[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGES mRNA21873648
D012969Sodium FluorideSodium Fluoride results in decreased expression of PTGES protein28918527
D018038Sodium SeleniteSodium Selenite results in decreased expression of PTGES mRNA21669866
D018038Sodium SeleniteSodium Selenite results in decreased expression of PTGES protein21669866
C025026sodium sulfite[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGES mRNA21873648
D012999SomanSoman results in increased expression of PTGES mRNA19281266
D053260SootSoot results in increased expression of PTGES mRNA22461453|2655175
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PTGES mRNA19059307
D013629TamoxifenTamoxifen affects the expression of PTGES mRNA17555576
C011363terephthalic acidterephthalic acid results in increased expression of PTGES mRNA16621493
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PTGES mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in decreased expression of PTGES mRNA19074003
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PTGES mRNA25172293
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PTGES mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTGES mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTGES mRNA21496263
D013749TetrachlorodibenzodioxinPTGES protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of KCNJ1 mRNA]22430074
D013749TetrachlorodibenzodioxinPTGES protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC12A1 mRNA]22430074
D013749TetrachlorodibenzodioxinPTGES protein affects the reaction [Tetrachlorodibenzodioxin results in increased abundance of Dinoprostone]22430074
D013749TetrachlorodibenzodioxinPTGES protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA]22430074
D013749TetrachlorodibenzodioxinPTGES protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of SRC mRNA]22430074
D013749TetrachlorodibenzodioxinPTGES protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]22430074
D013749TetrachlorodibenzodioxinPTGES protein affects the susceptibility to Tetrachlorodibenzodioxin22430074
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTGES mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PTGES mRNA15251184
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of PTGES mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [EGR1 protein binds to PTGES promoter]25015655
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTGES mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTGES mRNA15328365|2149626
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased expression of PTGES mRNA] which results in increased chemical synthesis of Dinoprostone22430074
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of PTGES mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with arsenic trioxide] results in increased expression of PTGES mRNA18922899
D014212TretinoinTretinoin results in increased expression of PTGES mRNA23830798
D014212TretinoinTretinoin results in increased expression of PTGES mRNA16604517|1678809
D014260TriclosanTriclosan inhibits the reaction [TNF protein results in increased expression of PTGES mRNA]15642051
D014260TriclosanTriclosan inhibits the reaction [TNF protein results in increased expression of PTGES protein]15642051
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid affects the expression of PTGES mRNA25526689
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PTGES mRNA25526689
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PTGES mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of PTGES mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of PTGES gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PTGES mRNA24896083
D014635Valproic AcidValproic Acid results in increased expression of PTGES mRNA15379904
C029297vinylidene chloridevinylidene chloride results in decreased expression of PTGES mRNA26682919
D002762CholecalciferolCholecalciferol results in increased expression of PTGES mRNA17170073
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of PTGES mRNA19244175
D014810Vitamin EVitamin E results in increased expression of PTGES mRNA19244175
D015032ZincZinc deficiency results in increased expression of PTGES mRNA19111725
D015032ZincZinc deficiency results in increased expression of PTGES protein19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of PTGES mRNA]19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of PTGES protein]19111725
D015054ZymosanZymosan results in increased expression of PTGES mRNA15708354

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IBA21873635  
GO:0043295glutathione binding-IDA18682561  
GO:0050220prostaglandin-E synthase activity-EXP18682561  
GO:0050220prostaglandin-E synthase activity-IBA21873635  
GO:0050220prostaglandin-E synthase activityNOTIBA21873635  
GO:0050220prostaglandin-E synthase activity-IDA18682561  
GO ID GO Term Qualifier Evidence PubMed
GO:0001516prostaglandin biosynthetic process-IBA21873635  
GO:0001516prostaglandin biosynthetic processNOTIBA21873635  
GO:0001516prostaglandin biosynthetic process-IDA18682561  
GO:0002526acute inflammatory response-IEA-  
GO:0002544chronic inflammatory response-IEA-  
GO:0006693prostaglandin metabolic process-TAS10377395  
GO:0006749glutathione metabolic process-IBA21873635  
GO:0007165signal transduction-NAS10377395  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0019371cyclooxygenase pathway-TAS-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0032526response to retinoic acid-IEA-  
GO:0034097response to cytokine-IEA-  
GO:0051592response to calcium ion-IEA-  
GO:0055114oxidation-reduction process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005641nuclear envelope lumen-IEA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-TAS10377395  
GO:0016021integral component of membrane-IDA18682561  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2162123Synthesis of Prostaglandins (PG) and Thromboxanes (TX)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal