Gene: CREB5

9586
CRE-BPA|CREB-5
cAMP responsive element binding protein 5
protein-coding
7p15.1
Ensembl:ENSG00000146592 Vega:OTTHUMG00000097081 UniprotKB:Q02930
NC_000007.14
SNP Mapped
4   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.264e-1 (AD)  6.541e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2190305chr7:28819833 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2237361chr7:28792680 (GRCh38.p7)T>C / T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs4719953chr7:28774165 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs16874653chr7:28675439 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHIP0.911
C10orf900.906
TMEM1440.898
COL4A50.893
PLEKHH10.892
ERBB30.889
KCNH80.884
MYRF0.882
SH3TC20.881
TRIM590.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNA2-0.375
WTIP-0.367
CALB2-0.364
PRTN3-0.363
CUX2-0.356
SHISA8-0.345
PAX2-0.321
LTK-0.32
TAC3-0.319
NDNF-0.319

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CREB5 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CREB5 mRNA"23146750
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CREB5 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREB5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREB5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREB5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREB5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CREB5 mRNA26690555|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CREB5 gene27153756
D000393Air PollutantsAir Pollutants results in increased expression of CREB5 mRNA23649983
C006632arsenic trioxidearsenic trioxide results in increased expression of CREB5 mRNA15761015
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of CREB5 mRNA"17331233
D001379AzathioprineAzathioprine results in increased expression of CREB5 mRNA22623647
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CREB5 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CREB5 promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CREB5 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of CREB5 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of CREB5 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CREB5 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of CREB5 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CREB5 mRNA20938992
D019327Copper SulfateCopper Sulfate results in increased expression of CREB5 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of CREB5 mRNA27523638
D003471CuprizoneCuprizone results in increased expression of CREB5 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of CREB5 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of CREB5 mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of CREB5 mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CREB5 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CREB5 mRNA21266533
D002945CisplatinCisplatin affects the expression of CREB5 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CREB5 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CREB5 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of CREB5 mRNA25016146
C521792DMU-212DMU-212 affects the expression of CREB5 mRNA26428916
C118739entinostatentinostat results in decreased expression of CREB5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CREB5 mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CREB5 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CREB5 mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CREB5 mRNA18936297
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CREB5 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CREB5 mRNA28329830
D005485FlutamideFlutamide results in increased expression of CREB5 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CREB5 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of CREB5 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of CREB5 mRNA20655997
D019833GenisteinGenistein affects the expression of CREB5 mRNA26865667
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CREB5 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CREB5 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREB5 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CREB5 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CREB5 mRNA27392435
C008261lead acetatelead acetate results in increased expression of CREB5 mRNA24260418
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CREB5 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CREB5 mRNA25613284
D008558MelphalanMelphalan results in decreased expression of CREB5 mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CREB5 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CREB5 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CREB5 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CREB5 mRNA25234470
C523799MRK 003CREB5 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CREB5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CREB5 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of CREB5 mRNA22714537
C046012pentanalpentanal results in increased expression of CREB5 mRNA26079696
D010575PesticidesPesticides results in increased methylation of CREB5 gene28396702
D010634PhenobarbitalPhenobarbital affects the expression of CREB5 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CREB5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CREB5 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CREB5 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of CREB5 mRNA21795739
D011441PropylthiouracilPropylthiouracil results in decreased expression of CREB5 mRNA24780913
D000068718Rosuvastatin CalciumRosuvastatin Calcium results in decreased expression of CREB5 mRNA18192897
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CREB5 mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in increased expression of CREB5 mRNA22300531|2535159
D012834SilverSilver results in decreased expression of CREB5 mRNA27131904
D012839SimazineSimazine results in decreased expression of CREB5 mRNA22984576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CREB5 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CREB5 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CREB5 mRNA20819909
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CREB5 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CREB5 mRNA23409001
D014212TretinoinTretinoin results in decreased expression of CREB5 mRNA21934132
D014212TretinoinTretinoin results in increased expression of CREB5 mRNA23724009
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CREB5 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of CREB5 mRNA24383497|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CREB5 gene25560391
D015034Zinc OxideZinc Oxide analog results in decreased expression of CREB5 mRNA27185063
C088658zoledronic acidzoledronic acid results in decreased expression of CREB5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IDA8378084  
GO:0005515protein binding-IPI8440710  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-TAS8378084  
GO:0045893positive regulation of transcription, DNA-templated-IDA8378084  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC8378084  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04962Vasopressin-regulated water reabsorption
hsa05016Huntington's disease
hsa05215Prostate cancer
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal