Gene info: ID 9612

Gene: NCOR2

GENE ID: 9612

Description: nuclear receptor corepressor 2

Gene type: protein-coding

Location: 12q24.31

dbXrefs: Ensembl:ENSG00000196498 MIM:600848 Vega:OTTHUMG00000150455 UniprotKB:Q9Y618

RefSeq: NG_022928.2

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: CD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.824e-1 (AD) 8.989e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs150954431	chr12:124517777 (GRCh38.p7)	C>T	cocaine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg01400924	chr12:124947742	NCOR2	Gene body	1.208e-4	Alcohol use disorders	26763658
cg05596926	chr12:124929590	NCOR2	Gene body	1.363e-4	Alcohol use disorders	26763658
cg25763426	chr12:124905102	NCOR2	Gene body	3.172e-4	Alcohol use disorders	26763658
cg20352351	chr12:124870274	NCOR2	Gene body	5.123e-4	Alcohol use disorders	26763658
cg08143046	chr12:124929704	NCOR2	Gene body	5.894e-4	Alcohol use disorders	26763658
cg03507593	chr12:124939480	NCOR2		1.800e-9	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PTPN23	0.903
HCFC1	0.892
PHRF1	0.888
ANKRD11	0.881
MICAL3	0.874
SRCAP	0.874
TSC2	0.874
NFIX	0.873
CNOT3	0.873
ATXN2L	0.872

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.63
OR4F29	-0.605
MEI4	-0.363
AGTR1	-0.359
IRX5	-0.331
ODAM	-0.318
RPE65	-0.318
CLEC4D	-0.317
PROK2	-0.313
CRNDE	-0.312

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C492909	1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane	"[1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane binds to and results in increased activity of PPARG protein] inhibits the reaction [[manganese chloride co-treated with TNF protein co-treated with IFNG protein] promotes the reaction [NCOR2 protein binds to NOS2 enhancer]]"	18041089
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]	15773917
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of NCOR2 mRNA"	21346803
C012796	2-butenal	2-butenal results in decreased expression of NCOR2 mRNA	20471460
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NCOR2 mRNA"	28973690
C549543	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in decreased expression of NCOR2 mRNA	25716159
C583074	4,4'-hexafluorisopropylidene diphenol	"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOR2 protein modified form]"	28751236
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCOR2 mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of NCOR2 mRNA"	21346803
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCOR2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of NCOR2 mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in increased expression of NCOR2 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of NCOR2 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of NCOR2 gene	28458013
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of NCOR2 mRNA	19770486
C412373	AG 1879	AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
C412373	AG 1879	AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D013196	Dihydrotestosterone	Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]	16648561
D013196	Dihydrotestosterone	methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]]	16648561
D013196	Dihydrotestosterone	NCOR2 protein inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]	17804755
D015761	4-Aminopyridine	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]	15773917
D015761	4-Aminopyridine	[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein	15773917
D015761	4-Aminopyridine	KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]	15773917
D015761	4-Aminopyridine	STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]	15773917
D000737	Androstenols	Androstenols promotes the reaction [NCOR2 protein binds to NR1I3 protein]	28289823
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of NCOR2 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of NCOR2 gene	25304211
C015001	arsenite	arsenite results in increased expression of NCOR2 mRNA	18191166
D001280	Atrazine	Atrazine results in decreased expression of NCOR2 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NCOR2 mRNA	23306105
D001564	Benzo(a)pyrene	AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NCOR2 mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NCOR2 mRNA	15034205
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of and results in increased expression of NCOR2 protein	15857753
D004958	Estradiol	Estradiol promotes the reaction [NCOR2 protein binds to TFF1 promoter]	19698761
D004958	Estradiol	Estradiol results in decreased expression of NCOR2 mRNA	19432593
D004958	Estradiol	Estradiol results in increased expression of NCOR2 mRNA	20406620\|2301914
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]	20406620
D004958	Estradiol	U 0126 promotes the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]]	20406620
D004958	Estradiol	Estradiol affects the expression of NCOR2 mRNA	15598610
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of NCOR2 mRNA	26496021
C053541	bicalutamide	bicalutamide promotes the reaction [AR protein binds to NCOR2 protein]	11981028
D001640	Bicuculline	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]	15773917
D001640	Bicuculline	[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein	15773917
D001640	Bicuculline	KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]	15773917
D001640	Bicuculline	STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]	15773917
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NCOR2 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of NCOR2 mRNA	21786754
C006780	bisphenol A	[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOR2 protein modified form]	28751236
C006780	bisphenol A	bisphenol A inhibits the reaction [NCOR2 protein binds to and results in decreased activity of NR1I2 protein]	22214767
C006780	bisphenol A	bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
C006780	bisphenol A	bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
C006780	bisphenol A	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
C006780	bisphenol A	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
C006780	bisphenol A	SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
C006780	bisphenol A	SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
C006780	bisphenol A	bisphenol A promotes the reaction [NCOR2 protein binds to AR protein]	28645579
C006780	bisphenol A	bisphenol A affects the expression of NCOR2 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of NCOR2 mRNA	25181051
C006780	bisphenol A	bisphenol A affects the expression of NCOR2 protein	21513798
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of NCOR2 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of NCOR2 protein	18653720
C006780	bisphenol A	bisphenol A results in increased methylation of NCOR2 gene	28505145
C006780	bisphenol A	bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]	22227104
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NCOR2 mRNA	28628672
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of NCOR2 mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in decreased expression of NCOR2 mRNA	26079696
D020148	Butyric Acid	Butyric Acid results in increased expression of NCOR2 mRNA	23524101
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of NCOR2 mRNA	21297351
D002509	Cephaloridine	Cephaloridine results in decreased expression of NCOR2 mRNA	18500788
C017160	cypermethrin	cypermethrin promotes the reaction [AR protein binds to NCOR2 protein]	23831764
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NCOR2 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NCOR2 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of NCOR2 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate promotes the reaction [THRB protein binds to NCOR2 protein]	21544203
D003993	Dibutyl Phthalate	Triiodothyronine inhibits the reaction [Dibutyl Phthalate promotes the reaction [THRB protein binds to NCOR2 protein]]	21544203
D002945	Cisplatin	Cisplatin results in decreased expression of NCOR2 mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of NCOR2 mRNA	28302478
D002117	Calcitriol	Calcitriol inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]	21917910
D002117	Calcitriol	Calcitriol inhibits the reaction [VDR protein binds to NCOR2 protein]	21917910\|2246656
D002117	Calcitriol	Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]	20371703
D002117	Calcitriol	Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 promoter]	19106115
D002117	Calcitriol	NCOR2 protein inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
D002117	Calcitriol	NCOR2 protein inhibits the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]	20371703
D002117	Calcitriol	NCOR2 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]	20371703
D002117	Calcitriol	U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]]	20371703
D002117	Calcitriol	U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]]	20371703
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of NCOR2 mRNA	26924002
D004726	Endosulfan	Endosulfan results in increased expression of NCOR2 protein	25486513
D000431	Ethanol	Ethanol results in decreased expression of NCOR2 mRNA	29018328
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of NCOR2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of NCOR2 mRNA	17351261
C000611514	ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate	"ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate inhibits the reaction [NCOR2 protein binds to NR1I2 protein]"	28289823
C000611514	ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate	"ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate promotes the reaction [NCOR2 protein binds to NR1I3 protein]"	28289823
C082360	fipronil	fipronil results in decreased expression of NCOR2 mRNA	23962444
C070081	fulvestrant	fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOR2 protein binds to IL6 promoter]]	24771768
C010974	glyphosate	glyphosate results in increased expression of NCOR2 mRNA	26302742
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NCOR2 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NCOR2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NCOR2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NCOR2 mRNA	28628672
D007654	Ketoconazole	Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]	12072427
C063302	KN 62	KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]	15773917
C008261	lead acetate	lead acetate affects the expression of NCOR2 mRNA	21147602
C045463	leflunomide	leflunomide results in increased expression of NCOR2 mRNA	28988120
D008095	Lithocholic Acid	Lithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]	21917910
D008095	Lithocholic Acid	Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR2 protein]	21917910\|2246656
D008095	Lithocholic Acid	Lithocholic Acid promotes the reaction [VDR protein binds to NCOR2 protein]	22466564
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]	20371703
C502354	lithocholic acid acetate	lithocholic acid acetate promotes the reaction [NCOR2 protein binds to CYP7A1 promoter]	19106115
C502354	lithocholic acid acetate	NCOR2 protein inhibits the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]	20371703
C502354	lithocholic acid acetate	NCOR2 protein inhibits the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]	20371703
C502354	lithocholic acid acetate	NCOR2 protein promotes the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]	20371703
C025340	manganese chloride	"[1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane binds to and results in increased activity of PPARG protein] inhibits the reaction [[manganese chloride co-treated with TNF protein co-treated with IFNG protein] promotes the reaction [NCOR2 protein binds to NOS2 enhancer]]"	18041089
C025340	manganese chloride	[manganese chloride co-treated with TNF protein co-treated with IFNG protein] promotes the reaction [NCOR2 protein binds to NOS2 enhancer]	18041089
D008694	Methamphetamine	Methamphetamine results in increased expression of NCOR2 mRNA	26307267
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of NCOR2 mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCOR2 mRNA"	27188386
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of NCOR2 mRNA modified form	24694518
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of NCOR2 mRNA	26011545
D008770	Methylnitrosourea	Methylnitrosourea affects the expression of NCOR2 mRNA	21843606
D008774	Methylphenidate	Methylphenidate results in decreased expression of NCOR2 mRNA	22470460
C008493	methylselenic acid	methylselenic acid inhibits the reaction [Dihydrotestosterone inhibits the reaction [NCOR2 protein binds to KLK3 promoter]]	16648561
D015741	Metribolone	[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR2 protein modified form]	28751236
C028577	monobutyl phthalate	monobutyl phthalate promotes the reaction [THRB protein binds to NCOR2 protein]	21544203
C028577	monobutyl phthalate	Triiodothyronine inhibits the reaction [monobutyl phthalate promotes the reaction [THRB protein binds to NCOR2 protein]]	21544203
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of NCOR2 mRNA	26924002
C044361	M-VAC protocol	NCOR2 protein results in decreased susceptibility to M-VAC protocol	15814643
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of NCOR2 mRNA	25380136
D019319	Okadaic Acid	Okadaic Acid affects the localization of NCOR2 protein	15773917
C002669	parthenolide	parthenolide affects the localization of NCOR2 protein	21928377
C002669	parthenolide	SC-203048 promotes the reaction [parthenolide affects the localization of NCOR2 protein]	21928377
D010705	Phosgene	Phosgene affects the expression of NCOR2 mRNA	16300373
C045950	propiconazole	propiconazole results in decreased expression of NCOR2 mRNA	21278054
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to IGF1 promoter]	17872375
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to PTGS2 promoter]	17872375
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of NCOR2 mRNA	19432593
C059514	resveratrol	fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOR2 protein binds to IL6 promoter]]	24771768
D012293	Rifampin	[NR1I2 protein binds to NCOR2 protein] inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]	12072427
D012293	Rifampin	Rifampin inhibits the reaction [NCOR2 protein binds to and results in decreased activity of NR1I2 protein]	22214767
D012293	Rifampin	Rifampin inhibits the reaction [NCOR2 protein binds to NR1I2 protein]	28289823
D012293	Rifampin	Rifampin inhibits the reaction [NR1I2 protein binds to NCOR2 protein]	25313206
D012293	Rifampin	Rifampin inhibits the reaction [trichostatin A inhibits the reaction [[PIAS1 co-treated with SUMO3] inhibits the reaction [NCOR2 protein promotes the reaction [NR1I2 protein binds to HDAC3 protein]]]]	26883953
D012293	Rifampin	Rifampin promotes the reaction [NR1I2 protein binds to NCOR2 protein]	12072427
C057006	Ro 21-5104	Ro 21-5104 inhibits the reaction [NR1I2 protein binds to NCOR2 protein]	25313206
C572332	SC-203048	SC-203048 promotes the reaction [parthenolide affects the localization of NCOR2 protein]	21928377
C078903	seocalcitol	seocalcitol affects the expression of NCOR2 mRNA	21843606
C017947	sodium arsenite	sodium arsenite results in increased methylation of NCOR2 gene	24570342
C458525	STO 609	STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]	15773917
D014284	Triiodothyronine	Triiodothyronine results in increased expression of NCOR2 mRNA	23306105
D014284	Triiodothyronine	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D014284	Triiodothyronine	AG 1879 inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D014284	Triiodothyronine	bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D014284	Triiodothyronine	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
D014284	Triiodothyronine	SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
D014284	Triiodothyronine	tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D014284	Triiodothyronine	Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]	22227104
D014284	Triiodothyronine	Triiodothyronine inhibits the reaction [Dibutyl Phthalate promotes the reaction [THRB protein binds to NCOR2 protein]]	21544203
D014284	Triiodothyronine	Triiodothyronine inhibits the reaction [monobutyl phthalate promotes the reaction [THRB protein binds to NCOR2 protein]]	21544203
D014284	Triiodothyronine	Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]	22227104
C061133	tamibarotene	tamibarotene results in increased expression of NCOR2 mRNA	17229644
D013629	Tamoxifen	BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]]	18997820
D013629	Tamoxifen	BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]]	18997820
D013629	Tamoxifen	NCOR2 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein]	20406620
D013629	Tamoxifen	Tamoxifen inhibits the reaction [ESR1 protein binds to NCOR2 protein]	23665804
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]	20406620
D013629	Tamoxifen	Tamoxifen promotes the reaction [ESR1 protein binds to NCOR2 protein]	18997820
D013629	Tamoxifen	Tamoxifen promotes the reaction [NCOR2 protein binds to CCND1 promoter]	18997820
D013629	Tamoxifen	Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]	20406620
D013629	Tamoxifen	Tamoxifen promotes the reaction [NCOR2 protein binds to TFF1 promoter]	20406620
D013629	Tamoxifen	Tamoxifen results in decreased expression of NCOR2 mRNA	19432593
D013629	Tamoxifen	U 0126 promotes the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]]	20406620
D013629	Tamoxifen	U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]]	20406620
D013629	Tamoxifen	U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to TFF1 promoter]]	20406620
D013749	Tetrachlorodibenzodioxin	NCOR2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]	12139968
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of NCOR2 mRNA	21807756
D013749	Tetrachlorodibenzodioxin	AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NCOR2 mRNA]	15034205
D013749	Tetrachlorodibenzodioxin	NCOR2 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]]	12139968
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NCOR2 mRNA	24680724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NCOR2 protein]	12139968
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NCOR2 mRNA	15034205
D013749	Tetrachlorodibenzodioxin	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NCOR2 mRNA]	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NCOR2 mRNA	21215274
C011126	tetraiodothyroacetic acid	tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
C011126	tetraiodothyroacetic acid	tetraiodothyroacetic acid inhibits the reaction [Triiodothyronine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D013974	Thyroxine	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D013974	Thyroxine	AG 1879 inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D013974	Thyroxine	bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D013974	Thyroxine	ITGB3 inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
D013974	Thyroxine	SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]	22227104
D013974	Thyroxine	tetraiodothyroacetic acid inhibits the reaction [Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]]	22227104
D013974	Thyroxine	Thyroxine inhibits the reaction [THRB protein binds to NCOR2 protein]	22227104
D013974	Thyroxine	bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]	22227104
D013974	Thyroxine	Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]	22227104
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of NCOR2 gene	26756918
C012589	trichostatin A	Rifampin inhibits the reaction [trichostatin A inhibits the reaction [[PIAS1 co-treated with SUMO3] inhibits the reaction [NCOR2 protein promotes the reaction [NR1I2 protein binds to HDAC3 protein]]]]	26883953
C012589	trichostatin A	trichostatin A inhibits the reaction [[PIAS1 co-treated with SUMO3] inhibits the reaction [NCOR2 protein promotes the reaction [NR1I2 protein binds to HDAC3 protein]]]	26883953
C012589	trichostatin A	trichostatin A affects the localization of NCOR2 protein	15773917
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of NCOR2 mRNA	23306105
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NCOR2 mRNA"	23306105
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of NCOR2 mRNA	27776230
C057693	troglitazone	troglitazone results in decreased expression of NCOR2 mRNA	28973697
C113580	U 0126	U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]]	20371703
C113580	U 0126	U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP7A1 mRNA]]	20371703
C113580	U 0126	U 0126 promotes the reaction [NCOR2 protein binds to ESR1 protein]	20406620
C113580	U 0126	[U 0126 promotes the reaction [NCOR2 protein binds to ESR1 protein]] which results in decreased activity of ESR1 protein	20406620
C113580	U 0126	U 0126 promotes the reaction [Tamoxifen inhibits the reaction [Estradiol results in increased expression of NCOR2 mRNA]]	20406620
C113580	U 0126	U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to PGR promoter]]	20406620
C113580	U 0126	U 0126 promotes the reaction [Tamoxifen promotes the reaction [NCOR2 protein binds to TFF1 promoter]]	20406620
C113580	U 0126	U 0126 results in decreased expression of NCOR2 mRNA	20406620
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of NCOR2 gene	25560391
D014807	Vitamin D	Vitamin D analog inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]	21917910
D014807	Vitamin D	Vitamin D analog inhibits the reaction [VDR protein binds to NCOR2 protein]	21917910
D014807	Vitamin D	Vitamin D analog promotes the reaction [NCOR2 protein binds to CYP24A1 promoter]	21917910
D014807	Vitamin D	Vitamin D analog promotes the reaction [[NCOR2 protein binds to VDR protein] which binds to CYP24A1 promoter]	21917910
D002762	Cholecalciferol	Cholecalciferol affects the expression of NCOR2 mRNA	21843606
D024483	Vitamin K 3	Vitamin K 3 affects the expression of NCOR2 mRNA	20044591
C111237	vorinostat	vorinostat results in decreased activity of [HDAC3 protein binds to NCOR2 protein]	21548582

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0003677	DNA binding	-	IEA	-
GO:0003714	transcription corepressor activity	-	IBA	21873635
GO:0003714	transcription corepressor activity	-	IDA	18052923
GO:0003714	transcription corepressor activity	-	IMP	12628926
GO:0005112	Notch binding	-	IPI	10713164
GO:0005515	protein binding	-	IPI	10395741 10713164 10809664 11013263 11739383 11845213 14985122 15016912 16129689 16924111 16980585 19786558 19955185 20195357 20467437 20543827 21258344 21475249 21624135 22230954 23518351 23752268 24268649 24449765 25303530
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0016922	ligand-dependent nuclear receptor binding	-	IBA	21873635
GO:0042826	histone deacetylase binding	-	IPI	11804585 16924111
GO:0047485	protein N-terminus binding	-	IPI	16893456

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	12628926 18052923 19955185 20388878
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0019216	regulation of lipid metabolic process	-	TAS	-
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter	-	IMP	19955185
GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	-	IMP	20388878

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000118	histone deacetylase complex	-	IBA	21873635
GO:0000790	nuclear chromatin	-	IDA	20388878
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IC	18052923
GO:0005634	nucleus	-	IDA	12628926
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0016363	nuclear matrix	-	IDA	21328542
GO:0016604	nuclear body	-	IDA	16030140
GO:0017053	transcriptional repressor complex	-	IDA	11804585

KEGG ID	KEGG Term
hsa04330	Notch signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	IEA
R-HSA-1980143	Signaling by NOTCH1	IEA
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	TAS
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	IEA
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	TAS
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	IEA
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	TAS
R-HSA-2644603	Signaling by NOTCH1 in Cancer	TAS
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	TAS
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	TAS
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	TAS
R-HSA-3214815	HDACs deacetylate histones	TAS
R-HSA-3247509	Chromatin modifying enzymes	TAS
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	IEA
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-4839726	Chromatin organization	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-9006936	Signaling by TGF-beta family members	TAS
R-HSA-9006936	Signaling by TGF-beta family members	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23958962	Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (2014 Jun)	Gelernter J	Mol Psychiatry