Gene: ABCG1

9619
ABC8|WHITE1
ATP binding cassette subfamily G member 1
protein-coding
21q22.3
Ensembl:ENSG00000160179 MIM:603076 Vega:OTTHUMG00000086791 UniprotKB:P45844
NC_000021.9
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.617e-1 (AD)  6.123e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3788007chr21:42286666 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRTC30.741
SHROOM40.735
USP540.734
MOB3B0.733
TCP11L20.716
KIAA03550.716
PIK3C2B0.715
ATP11A0.709
PSEN10.708
DIP2A0.708

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.385
OR4F29-0.372
HES5-0.253
GOLGA6L1-0.24
TNFRSF18-0.224
OR2A2-0.209
BRDT-0.202
VCX3A-0.197
SPDEF-0.186
SPANXA2-0.184

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0024481,2-linoleoylphosphatidylcholine"1,2-linoleoylphosphatidylcholine results in decreased expression of ABCG1 protein"19717637
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ABCG1 mRNA25596134
C00358522-hydroxycholesterol22-hydroxycholesterol results in increased expression of ABCG1 mRNA16730733
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ABCG1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ABCG1 mRNA"19167446
C04456324-hydroxycholesterol24-hydroxycholesterol results in increased expression of ABCG1 protein19126211
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of ABCG1 protein17088262
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ABCG1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ABCG1 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ABCG1 mRNA"25380136
D000082AcetaminophenAcetaminophen results in increased expression of ABCG1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ABCG1 mRNA17562736
D000111AcetylcysteineAcetylcysteine results in decreased expression of ABCG1 mRNA16084531
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of ABCG1 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ABCG1 mRNA27153756
C103303alitretinoinalitretinoin results in increased expression of ABCG1 mRNA16730733
C103303alitretinoin[TO-901317 co-treated with alitretinoin] results in increased expression of ABCG1 mRNA16024918
C103303alitretinoinalitretinoin results in increased expression of ABCG1 mRNA16024918
C103303alitretinoin[TO-901317 co-treated with alitretinoin] results in increased expression of ABCG1 mRNA16024918
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ABCG1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABCG1 mRNA16483693
C530884anacetrapib"ABCG1 protein promotes the reaction [anacetrapib results in increased export of Cholesterol, HDL]"20448206
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ABCG1 mRNA24449571
D016718Arachidonic AcidArachidonic Acid results in decreased expression of ABCG1 mRNA16730733
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ABCG1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ABCG1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ABCG1 mRNA22300585
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ABCG1 mRNA21839799
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ABCG1 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of ABCG1 mRNA19167446
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in decreased expression of ABCG1 mRNA25270620
C006780bisphenol Abisphenol A affects the expression of ABCG1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ABCG1 mRNA25270620|2750257
C006780bisphenol Abisphenol A results in increased expression of ABCG1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ABCG1 mRNA23824090|2435693
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ABCG1 mRNA25270620
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ABCG1 mRNA22079614
D002104CadmiumCadmium affects the expression of ABCG1 mRNA alternative form26125595
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ABCG1 protein17544377
C084597chlorcyclizinechlorcyclizine results in decreased expression of ABCG1 mRNA21058326
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of ABCG1 mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ABCG1 mRNA25270620
D002784Cholesterol[resveratrol results in increased expression of ABCG1 protein] which results in increased secretion of Cholesterol20372816
D002784CholesterolCholesterol results in increased expression of ABCG1 mRNA15342687
D002784CholesterolHCAR2 protein inhibits the reaction [[Niacin results in increased expression of ABCG1 protein] which results in increased export of Cholesterol]21317532
D002784Cholesterol[Niacin results in increased expression of ABCG1 protein] which results in increased export of Cholesterol21317532
D002784CholesterolABCG1 affects the export of Cholesterol17194745
D002784CholesterolABCG1 protein affects the export of Cholesterol16024918
D002784CholesterolABCG1 protein results in increased secretion of Cholesterol20372816
D008076Cholesterol, HDL"ABCG1 protein promotes the reaction [anacetrapib results in increased export of Cholesterol, HDL]"20448206
D008076Cholesterol, HDL"ABCG1 protein promotes the reaction [Niacin results in increased export of Cholesterol, HDL]"20448206
C059262cidofovircidofovir results in decreased expression of ABCG1 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of ABCG1 mRNA25596134
D002994ClofibrateClofibrate results in decreased expression of ABCG1 mRNA25270620
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCG1 mRNA17602206
C480342clothianidinclothianidin results in decreased expression of ABCG1 mRNA29044138
D003024ClozapineClozapine results in increased expression of ABCG1 mRNA17346280
D003300Copper[Disulfiram binds to Copper] which results in increased expression of ABCG1 mRNA24690739
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ABCG1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of ABCG1 mRNA19167446
D003474CurcuminCurcumin results in increased expression of ABCG1 mRNA16713233|2159464
D016572CyclosporineCyclosporine results in increased expression of ABCG1 mRNA20106945|2559613
D016572CyclosporineCyclosporine results in decreased expression of ABCG1 mRNA25596134
C017160cypermethrincypermethrin results in decreased expression of ABCG1 mRNA25424538
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ABCG1 mRNA23914054
C014347decitabinedecitabine affects the expression of ABCG1 mRNA23300844
D003976DiazinonDiazinon results in increased expression of ABCG1 mRNA24356939
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ABCG1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ABCG1 mRNA21266533
D002945CisplatinCisplatin affects the expression of ABCG1 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of ABCG1 mRNA25596134
D004041Dietary Fats[Oligosaccharides co-treated with Dietary Fats] results in increased expression of ABCG1 mRNA28549616
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ABCG1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ABCG1 mRNA17602206
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ABCG1 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ABCG1 mRNA25380136
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of ABCG1 mRNA24690739
C067311docetaxelABCG1 gene SNP affects the susceptibility to docetaxel23758476
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in decreased expression of ABCG1 mRNA16730733
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in decreased expression of ABCG1 protein16730733
C118739entinostatentinostat results in increased expression of ABCG1 mRNA26272509
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of ABCG1 mRNA16084531
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of ABCG1 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of ABCG1 mRNA21233418
D000431EthanolEthanol results in increased expression of ABCG1 mRNA17478430
D000431EthanolEthanol results in increased expression of ABCG1 protein17478430
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ABCG1 mRNA17351261|1755790
D011345FenofibrateFenofibrate results in increased expression of ABCG1 mRNA25596134
C061365flusilazoleflusilazole results in decreased expression of ABCG1 mRNA22664269
D005839GentamicinsGentamicins results in increased expression of ABCG1 mRNA22061828
D005944GlucosamineGlucosamine results in increased expression of ABCG1 mRNA17109745
C473027GW 3965GW 3965 results in increased expression of ABCG1 mRNA17449538
C473027GW 3965GW 3965 results in increased expression of ABCG1 mRNA15633131
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of ABCG1 mRNA25270620
D007052IbuprofenIbuprofen results in increased expression of ABCG1 mRNA25596134
D007069IfosfamideIfosfamide results in decreased expression of ABCG1 mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCG1 mRNA25613284
D007559IvermectinIvermectin results in decreased expression of ABCG1 mRNA26471037
D007649KetamineKetamine results in increased expression of ABCG1 mRNA20080153
D048628KetolidesKetolides analog results in increased expression of ABCG1 mRNA24967691
D001556LindaneLindane results in increased expression of ABCG1 mRNA24356939
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of ABCG1 mRNA]22240665
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of ABCG1 protein]22240665
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [TO-901317 results in increased expression of ABCG1 mRNA]22240665
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ABCG1 mRNA12057914|2224066
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ABCG1 protein22240665
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ABCG1 mRNA12057914
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ABCG1 mRNA26378955
D008628MercuryMercury results in increased expression of ABCG1 mRNA16823088
C523799MRK 003ABCG1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of ABCG1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ABCG1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ABCG1 mRNA25380136
D009525Niacin"ABCG1 protein promotes the reaction [Niacin results in increased export of Cholesterol, HDL]"20448206
D009525NiacinHCAR2 protein inhibits the reaction [[Niacin results in increased expression of ABCG1 protein] which results in increased export of Cholesterol]21317532
D009525NiacinNiacin results in increased expression of ABCG1 protein21317532
D009525Niacin[Niacin results in increased expression of ABCG1 protein] which results in increased export of Cholesterol21317532
D009525NiacinNiacin results in decreased expression of ABCG1 protein19878707
D009532NickelNickel results in decreased expression of ABCG1 mRNA24768652|2558310
D009532NickelNickel results in decreased expression of ABCG1 mRNA12540486
C022838nickel chloridenickel chloride results in increased expression of ABCG1 mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of ABCG1 mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ABCG1 mRNA17616710
C464660obeticholic acidobeticholic acid results in decreased expression of ABCG1 mRNA27939613
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of ABCG1 mRNA24356939
C025589ochratoxin Aochratoxin A results in decreased expression of ABCG1 mRNA24356939
D019787Linoleic AcidLinoleic Acid results in decreased expression of ABCG1 mRNA16730733
D019787Linoleic AcidLinoleic Acid results in decreased expression of ABCG1 protein16730733
D019301Oleic AcidOleic Acid results in decreased expression of ABCG1 mRNA16730733
D019301Oleic AcidOleic Acid results in decreased expression of ABCG1 protein16730733
D009844Oligosaccharides[Oligosaccharides co-treated with Dietary Fats] results in increased expression of ABCG1 mRNA28549616
D010098OxycodoneOxycodone results in decreased expression of ABCG1 mRNA23439660
D010100OxygenOxygen deficiency results in decreased expression of ABCG1 mRNA25596134
D010126OzoneOzone inhibits the reaction [TO-901317 results in increased expression of ABCG1 mRNA]27703007
D019308Palmitic AcidPalmitic Acid results in increased expression of ABCG1 mRNA16730733
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ABCG1 mRNA26705709
D010416PentachlorophenolPentachlorophenol results in decreased expression of ABCG1 mRNA23892564
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of ABCG1 mRNA29112762
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ABCG1 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ABCG1 mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ABCG1 mRNA16221955
D010672PhenytoinPhenytoin results in decreased expression of ABCG1 mRNA15136057
D010795Phthalic AcidsPhthalic Acids results in increased expression of ABCG1 mRNA15728792
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ABCG1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ABCG1 mRNA23811191
D059808PolyphenolsPolyphenols results in decreased expression of ABCG1 mRNA16293270
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ABCG1 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of ABCG1 mRNA21540246
D011374ProgesteroneProgesterone results in increased expression of ABCG1 mRNA18070364
D011374ProgesteroneProgesterone results in increased expression of ABCG1 mRNA20726854
C502851quinocetonequinocetone results in increased expression of ABCG1 mRNA27046791
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of ABCG1 mRNA14699072
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of ABCG1 mRNA19167446
C059514resveratrolPPARG protein promotes the reaction [resveratrol results in increased expression of ABCG1 mRNA]23041272
C059514resveratrolresveratrol results in increased activity of ABCG1 protein23770099
C059514resveratrolresveratrol results in increased expression of ABCG1 mRNA16901463
C059514resveratrolresveratrol results in increased expression of ABCG1 protein20372816|2304127
C059514resveratrol[resveratrol results in increased expression of ABCG1 protein] which results in increased secretion of Cholesterol20372816
C059514resveratrolZM 241385 inhibits the reaction [resveratrol results in increased expression of ABCG1 protein]23041272
D015474IsotretinoinIsotretinoin results in increased expression of ABCG1 protein17478430
D012293RifampinRifampin results in increased expression of ABCG1 mRNA12040753|1708826
D012293RifampinRifampin results in increased expression of ABCG1 protein17088262
C089730rosiglitazone[CGA protein co-treated with FSHB protein co-treated with rosiglitazone] results in increased expression of ABCG1 mRNA20926582
C089730rosiglitazoneLipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of ABCG1 mRNA]22240665
C089730rosiglitazoneLipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of ABCG1 protein]22240665
C089730rosiglitazonerosiglitazone results in increased expression of ABCG1 mRNA22240665
C089730rosiglitazonerosiglitazone results in increased expression of ABCG1 protein22240665
D000068718Rosuvastatin CalciumRosuvastatin Calcium results in decreased expression of ABCG1 mRNA18192897
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ABCG1 mRNA21427059
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of ABCG1 mRNA12818353
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ABCG1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ABCG1 mRNA25351596
D019821SimvastatinSimvastatin results in decreased expression of ABCG1 mRNA19383813
D019821SimvastatinSimvastatin results in decreased expression of ABCG1 mRNA22120639
D053260SootSoot results in decreased expression of ABCG1 mRNA22461453
C031183stearic acidstearic acid results in increased expression of ABCG1 mRNA16730733
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ABCG1 mRNA26378955
D013629TamoxifenTamoxifen results in increased expression of ABCG1 protein27358406
C084178telmisartanPPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA]22124178
C084178telmisartantelmisartan results in increased expression of ABCG1 mRNA22124178
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABCG1 mRNA24680724|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABCG1 mRNA28238261
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCG1 mRNA22808131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of ABCG1 gene26431795
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCG1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of ABCG1 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of ABCG1 mRNA23409001|2355797
C423915TO-901317Ozone inhibits the reaction [TO-901317 results in increased expression of ABCG1 mRNA]27703007
C423915TO-901317[TO-901317 co-treated with alitretinoin] results in increased expression of ABCG1 mRNA16024918
C423915TO-901317TO-901317 results in increased expression of ABCG1 mRNA16024918|1744953
C423915TO-901317TO-901317 results in increased expression of ABCG1 protein17088262
C423915TO-901317[TO-901317 co-treated with CGA protein co-treated with FSHB protein] results in increased expression of ABCG1 mRNA20926582
C423915TO-901317TO-901317 results in increased expression of ABCG1 mRNA22156476
C423915TO-901317Lipopolysaccharides inhibits the reaction [TO-901317 results in increased expression of ABCG1 mRNA]22240665
C423915TO-901317[TO-901317 co-treated with alitretinoin] results in increased expression of ABCG1 mRNA16024918
C423915TO-901317TO-901317 promotes the reaction [PARP1 protein binds to ABCG1 promoter]27026705
C423915TO-901317TO-901317 results in increased expression of ABCG1 mRNA16024918|2224066
D014212TretinoinTretinoin results in increased expression of ABCG1 mRNA21934132|2372400
C032910triadimefontriadimefon results in increased expression of ABCG1 mRNA26705709
C011559tributyltintributyltin results in increased expression of ABCG1 mRNA23824090|2435693
C012589trichostatin Atrichostatin A results in decreased expression of ABCG1 mRNA26705709
C057693troglitazonetroglitazone results in increased expression of ABCG1 mRNA25596134
D014635Valproic AcidValproic Acid affects the expression of ABCG1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ABCG1 mRNA19101580|2037128
D014635Valproic AcidValproic Acid affects the expression of ABCG1 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of ABCG1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ABCG1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ABCG1 mRNA23034163
D014750Vincristine[Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCG1 mRNA19944135
D015032ZincZinc deficiency results in increased expression of ABCG1 mRNA22171008
D015032ZincZinc results in increased expression of ABCG1 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of ABCG1 mRNA17074742
C097270ZM 241385ZM 241385 inhibits the reaction [resveratrol results in increased expression of ABCG1 protein]23041272

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IDA16702602  
GO:0005543phospholipid binding-IC16702602  
GO:0005548phospholipid transporter activity-IDA16702602  
GO:0015485cholesterol binding-IC15994327  
GO:0017127cholesterol transporter activity-IBA21873635  
GO:0017127cholesterol transporter activity-IDA15994327  
GO:0017127cholesterol transporter activity-TAS-  
GO:0019534toxin transmembrane transporter activity-IDA17408620  
GO:0034041sterol-transporting ATPase activity-IBA21873635  
GO:0034041sterol-transporting ATPase activity-IDA17408620  
GO:0034437glycoprotein transporter activity-IDA17293612  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0042803protein homodimerization activity-IDA16870176  
GO:0043531ADP binding-IDA16702602  
GO:0046982protein heterodimerization activity-IPI16870176  
GO:0046983protein dimerization activity-NAS11500512  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-ISS-  
GO:0008203cholesterol metabolic process-IDA15994327  
GO:0009720detection of hormone stimulus-NAS11500512  
GO:0010033response to organic substance-IDA11500512  
GO:0010745negative regulation of macrophage derived foam cell differentiation-TAS18490524  
GO:0010872regulation of cholesterol esterification-ISS16556852  
GO:0010875positive regulation of cholesterol efflux-IEA-  
GO:0010887negative regulation of cholesterol storage-TAS18490524  
GO:0030301cholesterol transport-IBA21873635  
GO:0032367intracellular cholesterol transport-IMP15994327  
GO:0033344cholesterol efflux-IBA21873635  
GO:0033344cholesterol efflux-IDA15994327  
GO:0033700phospholipid efflux-IMP16702602  
GO:0033993response to lipid-IDA16556852  
GO:0034374low-density lipoprotein particle remodeling-ISS16556852  
GO:0034375high-density lipoprotein particle remodeling-ISS16556852  
GO:0034375high-density lipoprotein particle remodeling-TAS-  
GO:0034436glycoprotein transport-IDA17293612  
GO:0042632cholesterol homeostasis-IDA15994327  
GO:0042987amyloid precursor protein catabolic process-IDA17293612  
GO:0043691reverse cholesterol transport-ISS-  
GO:0045542positive regulation of cholesterol biosynthetic process-ISS-  
GO:0055085transmembrane transport-IBA21873635  
GO:0055085transmembrane transport-TAS-  
GO:0055091phospholipid homeostasis-IMP16702602  
GO:0071403cellular response to high density lipoprotein particle stimulus-IEA-  
GO:1901998toxin transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005739mitochondrion-IDA22042635  
GO:0005768endosome-ISS-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005794Golgi apparatus-HDA16780588  
GO:0005886plasma membrane-HDA16780588  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IDA16556852  
GO:0055037recycling endosome-ISS16556852  
KEGG ID KEGG Term
hsa02010ABC transporters
Reactome ID Reactome Term Evidence
R-HSA-1369062ABC transporters in lipid homeostasisTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-8963899Plasma lipoprotein remodelingTAS
R-HSA-8964058HDL remodelingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19405812Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity. (2009 Apr)Berrougui HRejuvenation Res
28889112Interplay between cigarette smoking and pulmonary reverse lipid transport. (2017 Sep)Jubinville EEur Respir J
28194238Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study. (2017)Braun KVEClin Epigenetics
25084356A preliminary study of the relationship between promoter methylation of the ABCG1, GALNT2 and HMGCR genes and coronary heart disease. (2014)Peng PPLoS One
25601961The implication of cigarette smoking and cessation on macrophage cholesterol efflux in coronary artery disease patients. (2015 Mar)Song WJ Lipid Res
27019061Association between DNA Methylation in Whole Blood and Measures of Glucose Metabolism: KORA F4 Study. (2016)Kriebel JPLoS One
22614118The transcription levels of ABCA1, ABCG1 and SR-BI are negatively associated with plasma CRP in Chinese populations with various risk factors for atherosclerosis. (2012 Oct)Li CInflammation
22363809Monocyte gene expression signature of patients with early onset coronary artery disease. (2012)Sivapalaratnam SPLoS One