Gene: GUCA1C

9626
GCAP3
guanylate cyclase activator 1C
protein-coding
3q13.13
Ensembl:ENSG00000138472 MIM:605128 Vega:OTTHUMG00000159204 UniprotKB:O95843
NC_000003.12
SNP Mapped
1   ANCO-SNPs
ND
0   
6.403e-1 (AD)  4.202e-2 (ND)   (Frontal_Cortex)
8.108e-1 (AD)  1.895e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2715689chr3:108918583 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLCH10.506
OVOL20.491
CDCA50.478
GRM80.478
CPNE40.476
PRSS120.472
CHRM20.47
KCNH50.469
BMPER0.467
CYP26B10.465

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.339
MYL3-0.325
HEY2-0.325
STON2-0.324
OLAH-0.324
RAB13-0.32
MBNL3-0.32
HVCN1-0.318
PARD3B-0.316
DOK1-0.316

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GUCA1C mRNA21298039
C408042fullerol C60(OH)24fullerol C60(OH)24 results in decreased expression of GUCA1C mRNA21513982
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of GUCA1C mRNA26846883
D007854LeadLead results in increased expression of GUCA1C mRNA19921347
C059539midostaurinmidostaurin results in decreased expression of GUCA1C mRNA20980353
C009495titanium dioxidetitanium dioxide results in decreased expression of GUCA1C mRNA21513982
D019287Zinc SulfateZinc Sulfate results in decreased expression of GUCA1C mRNA27504894
C088658zoledronic acidzoledronic acid results in decreased expression of GUCA1C mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0008048calcium sensitive guanylate cyclase activator activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS10037746  
GO:0007601visual perception-IEA-  
GO:0022400regulation of rhodopsin mediated signaling pathway-TAS-  
GO:0031284positive regulation of guanylate cyclase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0097381photoreceptor disc membrane-TAS-  
KEGG ID KEGG Term
hsa04740Olfactory transduction
hsa04744Phototransduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-2514856The phototransduction cascadeTAS
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal