Gene: RGS6

9628
GAP|HA117|S914
regulator of G protein signaling 6
protein-coding
14q24.2
Ensembl:ENSG00000182732 MIM:603894 Vega:OTTHUMG00000171340 UniprotKB:P49758
NG_029236.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.072e-1 (AD)  2.380e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7159300chr14:72417166 (GRCh38.p7)G>A / G>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs11158954chr14:72415689 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LNX10.966
TMEM132D0.964
ATP8A20.96
OLFM30.955
DLG30.954
C11orf870.954
FRMPD40.952
PCSK20.952
GLT1D10.951
KIAA1549L0.951

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.631
YES1-0.63
REST-0.621
MYL3-0.601
CHST14-0.585
RNF135-0.584
COPZ2-0.583
ROM1-0.578
RAB13-0.577
RAI14-0.571

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of RGS6 mRNA"23829299
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of RGS6 protein26194647
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RGS6 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of RGS6 mRNA"23195993
D000638AmiodaroneAmiodarone results in increased expression of RGS6 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RGS6 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RGS6 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of RGS6 mRNA25181051
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RGS6 mRNA20360939
D003471CuprizoneCuprizone results in decreased expression of RGS6 mRNA27523638
D003471CuprizoneCuprizone results in increased expression of RGS6 mRNA26577399
D004041Dietary FatsDietary Fats results in increased expression of RGS6 mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RGS6 mRNA20360939
C007220dimethyl 2,3,5,6-tetrachloroterephthalate"dimethyl 2,3,5,6-tetrachloroterephthalate affects the expression of RGS6 mRNA"24050789
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RGS6 mRNA26752646
D007854LeadLead affects the expression of RGS6 mRNA28903495
D008345ManganeseManganese results in increased expression of RGS6 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of RGS6 mRNA17175027
D008627Mercuric ChlorideMercuric Chloride affects the expression of RGS6 mRNA20353558
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of RGS6 mRNA22401849
D009020MorphineMorphine results in increased expression of RGS6 mRNA21178816
C523799MRK 003MRK 003 results in decreased expression of RGS6 mRNA21169257
D009532NickelNickel results in increased expression of RGS6 mRNA23195993
C028007nickel monoxidenickel monoxide results in decreased expression of RGS6 mRNA19167457
D011441PropylthiouracilPropylthiouracil results in decreased expression of RGS6 mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of RGS6 gene28589171
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of RGS6 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IDA10521509  
GO:0005515protein binding-IPI22939624  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-TAS10083744  
GO:0009968negative regulation of signal transduction-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IDA10521509  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-IDA10521509  
GO:0019898extrinsic component of membrane-IDA10521509  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-390466Chaperonin-mediated protein foldingTAS
R-HSA-391251Protein foldingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-6814122Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25120791Decreased RGS6 expression is associated with poor prognosis in pancreatic cancer patients. (2014)Jiang NInt J Clin Exp Pathol
25646431Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol. (2015 Feb 17)Stewart AProc Natl Acad Sci U S A
27002730RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer. (2016 May)Ahlers KEAAPS J